Dietary carbohydrate restriction improves insulin sensitivity, blood pressure, microvascular function, and cellular adhesion markers in individuals taking statins

Ballard, Kevin D.; Quann, Erin E.; Kupchak, Brian R.; Volk, Brittanie M.; Kawiecki, Diana; Fernández, María Luz; Seip, Richard L.; Maresh, Carl M.; Kraemer, William J.; Volek, Jeff S.

doi:10.1016/j.nutres.2013.07.022

Cited by 35 publications

(44 citation statements)

References 37 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated refined carbohydrate and low fiber intake have been reported among SAIs in India as well [5]. High carbohydrate intake is a potential target for nutritional intervention because it has been associated with insulin resistance, a potent cardiovascular risk factor and antecedent to T2DM [20, 21]. …”

Section: Discussionmentioning

confidence: 99%

Dietary Profiles of First-Generation South Asian Indian Adolescents in the United States

Martyn‐Nemeth

Quinn

Menon

et al. 2016

J Immigrant Minority Health

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Dietary Profiles of First-Generation South Asian Indian Adolescents in the United States

Martyn‐Nemeth

Quinn

Menon

et al. 2016

J Immigrant Minority Health

View full text Add to dashboard Cite

“…Although statin treatment improves insulin sensitivity 22 23 in patients with PCOS, 12 increasing evidence shows that this therapy negatively affects glucose metabolism in hypercholesterolaemic patients with PCOS. 24 Animal experiments showed that atorvastatin can reduce insulin sensitivity and impair glucose tolerance in rats.…”

Section: Discussionmentioning

confidence: 99%

An investigation into the therapeutic effects of statins with metformin on polycystic ovary syndrome: a meta-analysis of randomised controlled trials

et al. 2015

View full text Add to dashboard Cite

ObjectivesTo investigate the therapeutic effects of statins with metformin on polycystic ovary syndrome (PCOS).SettingsEndocrinology department.ParticipantsMEDLINE, EMBASE and Cochrane Central Register of Controlled Trials were searched until October 2014. Studies comparing statins and placebo, as well as the combination of statins and metformin and metformin alone, were included in the analysis.InterventionsData were independently extracted by two researchers; any convergence was resolved by a third reviewer.Primary and secondary outcome measuresThe following properties were extracted from the qualified trials to identify the effects of statins: clinical variables, metabolic characteristics, hormone outcomes, sign of inflammation, glucose parameters and insulin outcomes.ResultsData from four trials comparing statin and metformin with metformin alone were analysed. The combination of statins and metformin decreases the levels of C reactive protein (standardised mean difference (SMD) −0.91; 95% CI −1.81 to −0.02; p=0.046), triglyceride (SMD −1.37; 95% CI −2.46 to −0.28; p=0.014), total cholesterol (SMD −1.28; 95% CI −1.59 to −0.97; p=0.000) and low-density lipoprotein (LDL) cholesterol (SMD −0.74; 95% CI −1.03 to −0.44; p=0.000). However, the combined therapy fails to reduce fasting insulin (SMD −0.92; 95% CI −2.07 to 0.24; p=0.120), homeostasis model assessment of insulin resistance (SMD −1.15; 95% CI −3.36 to 1.06; p=0.309) and total testosterone (SMD −1.12; 95% CI −2.29 to 0.05; p=0.061). Analysis of the five trials comparing statin with placebo shows that statin monotherapy reduces LDL-cholesterol, triglyceride and total cholesterol.ConclusionsCombined statin and metformin therapy can improve lipid and inflammation parameters, but cannot effectively improve insulin sensitivity and reduce hyperandrogenism in women with PCOS. A large-scale randomised controlled study must be conducted to ascertain the long-term effects of the therapy.

show abstract

“…These data suggest that the metabolic adaptations in response to a ketogenic diet are sufficient to at least maintain endurance capacity during exhaustive submaximal exercise, while simultaneously maximizing lipid utilization. Equally interesting are findings indicating keto-adapted individuals exhibit reduced inflammatory markers and muscle damage after an exercise bout, 113,114,117,118 indicating ketogenic diets may significantly facilitate postexercise recovery.…”

Section: Ketogenic Diet (Low-carbohydrate High-fat)mentioning

confidence: 99%

Exercise and Regulation of Lipid Metabolism

Noland

2015

Progress in Molecular Biology and Translational Science

View full text Add to dashboard Cite

Dietary carbohydrate restriction improves insulin sensitivity, blood pressure, microvascular function, and cellular adhesion markers in individuals taking statins

Cited by 35 publications

References 37 publications

Dietary Profiles of First-Generation South Asian Indian Adolescents in the United States

Dietary Profiles of First-Generation South Asian Indian Adolescents in the United States

An investigation into the therapeutic effects of statins with metformin on polycystic ovary syndrome: a meta-analysis of randomised controlled trials

Exercise and Regulation of Lipid Metabolism

Contact Info

Product

Resources

About