Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study

Warensjö, Eva; Byberg, Liisa; Melhus, Håkan; Gedeborg, Rolf; Mallmin, Hans; Wolk, Alicja; Michaëlsson, Karl

doi:10.1136/bmj.d1473

Cited by 186 publications

(180 citation statements)

References 40 publications

Supporting

Mentioning

161

Contrasting

Unclassified

Order By: Relevance

“…Blood samples were collected and prepared as plasma heparin, within the Swedish mammography cohort—clinical (SMC‐C; Dnr 2006/1490 and 2002/472c) 1, 10. The second set was from the Prospective Investigation of the vasculature in Uppsala Seniors cohort (PIVUS; Dnr 00–419 and 02–551) collected during 2001–2004 11.…”

Section: Methodsmentioning

confidence: 99%

“…Osteoporosis, a chronic noncommunicable disease characterized by reduced bone density and increased bone fragility leading to higher risk of fracture, represents a major public health problem that is set to increase in importance as the proportion of elderly women and men in the population is on the rise 1, 2. In the European Union alone, approximately 3.5 million new fragility fractures occur each year, but the great majority of individuals at risk are not identified or treated 3.…”

Section: Introductionmentioning

confidence: 99%

“…In the European Union alone, approximately 3.5 million new fragility fractures occur each year, but the great majority of individuals at risk are not identified or treated 3. Osteoporosis is estimated to affect over 200 million people worldwide 4 as primarily identified by bone mineral density scanning, so there is a need for a better understanding of the mechanisms behind osteoporosis in order to improve early diagnosis, patient mobility monitoring, and prevention of osteoporotic fractures 1.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Affinity proteomics discovers decreased levels of AMFR in plasma from Osteoporosis patients

Qundos

Drobin

Mattsson

et al. 2015

Proteomics Clinical Apps

View full text Add to dashboard Cite

PurposeAffinity proteomic approaches by antibody bead arrays enable multiplexed analysis of proteins in body fluids. In the presented study, we investigated blood plasma within osteoporosis to discovery differential protein profiles and to propose novel biomarkers candidates for subsequent studies.Experimental designStarting with 4608 antibodies and plasma samples from 22 women for an untargeted screening, a set of 72 proteins were suggested for further analysis. Complementing these with targets from literature and other studies, a targeted bead array of 180 antibodies was built to profile for 92 proteins in plasma samples of 180 women from two independent population‐based studies.ResultsDifferential profiles between osteoporosis patients and matched controls were discovered for 12 proteins in at least one of the two study sets. Among these targets, the levels of autocrine motility factor receptor (AMFR) were concordantly lower in plasma of female osteoporosis patients. Subsequently, verification of anti‐AMFR antibody selectivity was conducted using high‐density peptide and protein arrays, and Western blotting.Conclusions and clinical relevanceFurther validation in additional study sets will be needed to determine the clinical value of the observed decrease in AMFR plasma levels in osteoporosis patients, but AMFR may aid our understanding of disease mechanisms and could support existing tools for diagnosis and monitoring of patient mobility within osteoporosis.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Affinity proteomics discovers decreased levels of AMFR in plasma from Osteoporosis patients

Qundos

Drobin

Mattsson

et al. 2015

Proteomics Clinical Apps

View full text Add to dashboard Cite

show abstract

“…A recent longitudinal bone study has shown that calcium intakes of older adults [5] do not need to be much higher than 800 mg per day for optimal bone density measurements and low fracture rates, whereas intakes greater than 1200 mg per day result actually result in a greater rate of fractures. Another cross-sectional report of U.S. National Health and Nutrition Examination Survey data for 2005-2006 demonstrated that bone measurements of 50 to 80 year-olds were not related across a wide range of mean calcium intakes by quintiles from low to high total intakes of approximately 500 to 1200 mg per day [6].…”

Section: Calcium Intake and Bone Mass And Bone Fracturesmentioning

confidence: 99%

Relationships of Calcium to Skeletal Health and Potential Adverse Effects

Anderson¹

2016

J Clin Nutr Diet

View full text Add to dashboard Cite

“…The recommended daily amount of calcium for people over 65 years is 1000 mg [6]. Table 8.1 shows the main sources of calcium with minimum amounts of 250 mg and 100 mg calcium, which should be a regular part of meals to meet the needs.…”

mentioning

confidence: 99%

Nutrition and Hydration

Roigk

2018

Perspectives in Nursing Management and Care for Older Adults

View full text Add to dashboard Cite

Malnutrition and dehydration are important aspects of the care of older people, particularly those in hospitals or in long-term care facilities. Many older people do not eat and drink adequately during hospital stays and, following hip fracture, many patients achieve only a half of their recommended daily energy, protein and other nutritional requirements [1]. This leads to poor recovery and diminished health status and functional ability and results in a higher risk of other complications (Chap. 6).Nurses are the coordinators of the care process, so it is essential that they bring other health-care specialists together as a team to collaboratively provide highquality care that reflects patients' needs for assessment, intervention and health promotion. When an interdisciplinary team (orthogeriatric collaboration) work together care is more successful, improves patient outcomes and reduces the risk of the inhospital and long-term mortality.The aim of this chapter is to increase awareness of nurses' responsibility, within a multidisciplinary team, for assessment and intervention of nutrition and hydration, examine the issues pertaining to nutrition and fluid balance in older people and outline the nature, assessment and interventions relating to malnutrition and dehydration. Learning OutcomesAt the end of the chapter, and following further study, the nurse will be able to:

show abstract

Dietary calcium intake and risk of fracture and osteoporosis: prospective longitudinal cohort study

Abstract: Objective To investigate associations between long term dietary intake of calcium and risk of fracture of any type, hip fractures, and osteoporosis.

Cited by 186 publications

References 40 publications

Affinity proteomics discovers decreased levels of AMFR in plasma from Osteoporosis patients

Affinity proteomics discovers decreased levels of AMFR in plasma from Osteoporosis patients

Relationships of Calcium to Skeletal Health and Potential Adverse Effects

Nutrition and Hydration

Contact Info

Product

Resources

About