Dietary calcium in galactosaemia

Rutherford, Patricia; Davidson, D C; Matthai, Smita Mary

doi:10.1046/j.1365-277x.2002.00330.x

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sufficient intake of calories, protein, and micronutrients is essential for acquiring an optimal bone mass, and the lifelong galactose restriction may predispose patients to nutritional deficiencies (Wiesmann et al 1995;Rutherford et al 2002;El-Bassyouni et al 2006;Waisbren et al 2012). Furthermore, ovarian damage resulting in low estrogen concentrations is present in over 80% of female patients with CG (Fridovich-Keil et al 2011), which increases their susceptibility to the development of low bone mass.…”

Section: Introductionmentioning

confidence: 99%

Bone Health in Classic Galactosemia: Systematic Review and Meta-Analysis

et al. 2016

View full text Add to dashboard Cite

Introduction: Previous studies have reported an association between classic galactosemia (CG) and decreased bone mass. The primary objective of this systematic review with meta-analysis was to determine the extent of bone mineral density (BMD) Z-score reduction. Low BMD was defined as a Z-score À2 standard deviations (SD). The secondary objective was to evaluate other indicators of bone status through a descriptive analysis.Methods: Systematic search strategies were developed by an experienced clinical librarian. Selection of relevant manuscripts, risk of bias assessment, and data extraction were performed independently by two investigators.Results: Four studies were included in the meta-analysis. BMD Z-scores in children and adults with CG measured at the lumbar spine (LBMD; 4 studies; n ¼ 112), total hip (HBMD; 2 studies; n ¼ 58), and femoral neck (FBMD; 2 studies; n ¼ 73) were assessed. Mean BMD Z-scores in the CG population were LBMD À0.70 (95% CI: À0.88, À0.52); HBMD À0.89 (95% CI: À1.14, À0.64); and FBMD À0.63 (95% CI À1.29, 0.02). Results from studies included in the descriptive analysis (n ¼ 7) show that vitamin D levels were frequently in the low reference range, whereas serum calcium levels were within reference range.Communicated by: Alberto B. Burlina, MDThe authors "Britt van Erven" and "Lindsey Welling" are equal first authors.The authors "M. Estela Rubio-Gozalbo" and "Annet M. Bosch" are equal first authors. Electronic supplementary material:The online version of this chapter

show abstract

Section: Introductionmentioning

confidence: 99%

Bone Health in Classic Galactosemia: Systematic Review and Meta-Analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

Disorders of Carbohydrate Metabolism

Dixon¹,

MacDonald²

2007

Clinical Paediatric Dietetics

View full text Add to dashboard Cite

Galk Inhibitors for Classic Galactosemia

Lai

Boxer

2014

Future Med. Chem.

View full text Add to dashboard Cite

Classic galactosemia is an inherited metabolic disease for which, at present, no therapy is available apart from galactose-restricted diet. However, the efficacy of the diet is questionable, since it is not able to prevent the insurgence of chronic complications later in life. In addition, it is possible that dietary restriction itself could induce negative side effects. Therefore, there is a need for an alternative therapeutic approach that can avert the manifestation of chronic complications in the patients. In this review, the authors describe the development of a novel class of pharmaceutical agents that target the production of a toxic metabolite, galactose-1-phosphate, considered as the main culprit for the cause of the complications, in the patients.

show abstract

Dietary calcium in galactosaemia

Cited by 3 publications

References 5 publications

Bone Health in Classic Galactosemia: Systematic Review and Meta-Analysis

Bone Health in Classic Galactosemia: Systematic Review and Meta-Analysis

Disorders of Carbohydrate Metabolism

Galk Inhibitors for Classic Galactosemia

Contact Info

Product

Resources

About