Dietary calcium and cell membrane abnormality in genetic hypertension.

Furspan, Philip B.; Rinaldi, Gustavo; Hoffman, Kenneth E.; Bohr, David F.

doi:10.1161/01.hyp.13.6.727

Cited by 39 publications

(22 citation statements)

References 13 publications

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“…Moreover, normalization of blood pressure in SHR by ACE-inhibitor therapy has been reported to normalize the elevated [Ca2+], in lymphocytes of these animals (Arvola et al, 1993b). Previously, high dietary calcium intake has been found to lower blood pressure with an associated reduction in [Ca2+], in SHR (Furspan et al, 1989;P6rsti et al, 1992;Wuorela et al, 1992a). In the present study, basal [Ca2+]i in lymphocytes was clearly higher in SHR than WKY rats, and was reduced by dietary calcium supplementation, while increased magnesium intake did not affect [Ca2+]j.…”

Section: Resultsmentioning

confidence: 94%

“…The mechanisms underlying the antihypertensive effect of oral calcium loading, however, remain to be clarified. High calcium diet may correct the generalized membrane defect observed in hypertension, and thus reduce plasma membrane permeability to Ca2+ and other ions (Furspan et al, 1989). Calcium supplementation has also been shown to decrease the abnormally high Na', K+-ATPase inhibitory activity in plasma from hypertensive rats (Doris, 1988;1994).…”

Section: Introductionmentioning

confidence: 99%

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Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity

Mäkynen

Kähönen

Arvola

et al. 1995

British J Pharmacology

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1 High calcium diet attenuates the development of hypertension but an associated undesirable effect is that Mg2e loss to the urine is enhanced. Therefore, we studied the effects of high calcium diet alone and in combination with increased magnesium intake on blood pressure and arterial function. 2 Forty-eight young spontaneously hypertensive rats (SHR) were allocated into four groups, the dietary contents of Ca2" and Mg2+ being: 1.1%, 0.2% (SHR); 2.5%, 0.2% (Ca-SHR); 2.5%, 0.8% (CaMg-SHR); and 1.1%, 0.8% (Mg-SHR), respectively. Development of hypertension was followed for 13 weeks, whereafter electrolyte balance, lymphocyte intracellular free calcium ([Ca2+]

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Section: Resultsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity

Mäkynen

Kähönen

Arvola

et al. 1995

British J Pharmacology

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“…3 Both clinical and experimental studies suggest that blood pressure can be reduced by oral calcium supplementation. 4 - 6 However, contradictory results have also been published. 7 -8 The mechanisms underlying the possible blood pressure-lowering effect of calcium have not been fully clarified.…”

Section: High Calcium Diet Augments Vascular Potassium Relaxation In mentioning

confidence: 99%

High calcium diet augments vascular potassium relaxation in hypertensive rats.

et al. 1992

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The effects of increased dietary calcium on the development of hypertension and vascular smooth muscle responses were studied in spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. Both hypertensive and normotensive animals were divided into two groups; the calcium content of the normal diet was 1.1% and that of the high calcium diet 3.1%. During the 12-week study, calcium supplementation significantly attenuated the increase in systolic blood pressure in the hypertensive rats but did not affect blood pressure in the normotensive rats. The contractile responses of endothelium-denuded mesenteric arterial rings to potassium chloride were similar in all study groups. The contractions to norepinephrine were not altered by the high calcium diet either, but smooth muscle sensitivity to this agonist was lower in the normotensive than in the hypertensive rats. Potassium relaxation was used to evaluate the activity of vascular smooth muscle Na + ,K + -ATPas«. The maximal rate of potassium relaxation was fastest in the normotensive groups but was also clearly faster in calcium-treated hypertensive rats when compared with hypertensive rats on a normal diet Platelets were used as a cell model for the analysis of intracellular free calcium concentration, which was measured by the fluorescent indicator quin-2. Intracellular free calcium was significantly reduced in the hypertensive rats by calcium supplementation and was not affected in the normotensive rats. In conclusion, a reduction of intracellular free calcium concentration indicating improved calcium regulation and a concomitant alteration in vascular relaxation probably reflecting increased activity of smooth muscle Na + ,K + -ATPase may contribute to the blood pressure-lowering effect of a high calcium diet (Hypertension 1992;19:85-92)

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“…Mäkynen et al (1995) suggested that the reduction of blood pressure associated with increased dietary intake of calcium is induced by increased arterial relaxation. Furspan et al (1989) and Dominiczak et al (1991) observed strong evidence that increased extracellular calcium causes reduction in vascular contractility, but stabilization of the vascular membrane. Therefore, the calcium in EEAP could act synergistically with other compounds to determine both the vasodilatory action and the hypotensive effect observed with the administration of EEAP.…”

Section: Resultsmentioning

confidence: 99%

Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum

Silva

Lima

Caliman

et al. 2014

Braz. J. Pharm. Sci.

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The aims of this study were to evaluate the chemical profile, vascular reactivity, and acute hypotensive effect (AHE) of the ethanolic extract of leaves of Alpinia purpurata (Vieill) K. Schum (EEAP). Its chemical profile was evaluated using HPLC-UV, ICP-OES, and colorimetric quantification of total flavonoids and polyphenols. The vascular reactivity of the extract was determined using the mesenteric bed isolated from WKY. AHE dose-response curves were obtained for both EEAP and inorganic material isolated from AP (IAP) in WKY and SHR animals. Cytotoxic and mutagenic safety levels were determined by the micronucleus test. Rutin-like flavonoids were quantified in the EEAP (1.8 ± 0.03%), and the total flavonoid and polyphenol ratios were 4.1 ± 1.8% and 5.1 ± 0.3%, respectively. We observed that the vasodilation action of EEAP was partially mediated by nitric oxide ( ). The EEAP and IAP showed an AHE in WKY and SHR animals. EEAP did not have cytotoxic effects or cause chromosomic alterations. The AHE shown by EEAP could result from its endothelium-dependent vascular action. Rutin-like flavonoids, among other polyphenols, could contribute to these biological activities, and the calcium present in EEAP could act in a synergistic way.Uniterms: Alpinia. Alpinia purpurata/phytochemistry. Alpinia purpurata/ethanolic extract/vascular reactivity. Alpinia purpurata/ethanolic extract/acute hypotensive effect. Flavonoids/quantification. Polyphenols/quantification.Os objetivos deste estudo foram avaliar o perfil químico de folhas de Alpinia purpurata K. Schum (AP), assim como a reatividade vascular e o efeito hipotensor agudo (EHA) do extrato etanólico de folhas de AP (EEAP). Avliou-se o perfil químico utilizando-se HPLC-UV, ICP-OES e quantificação colorimétrica de flavonoides e polifenóis totais. A reatividade vascular foi determinada utilizando leito mesentérico isolado de ratos WKY. Curvas dose-resposta do EEAP e do material inorgânico da AP (IAP) foram realizadas em animais SHR e WKY. Determinaram-se a segurança citotóxica e mutagênica pelo teste de micronúcleos. Flavonoides tipo rutina foram quantificados no EEAP (1,8±0,03%) e flavonoide total e polifenóis foram de 4,1±1,8% e 5,1±0,3%, respectivamente. Observou-se ação vasodilatadora do EEAP, mediada parcialmente pelo óxido nítrico (

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Dietary calcium and cell membrane abnormality in genetic hypertension.

Cited by 39 publications

References 13 publications

Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity

Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity

High calcium diet augments vascular potassium relaxation in hypertensive rats.

Hypotensive effect and endothelium-dependent vascular action of leaves of Alpinia purpurata (Vieill) K. Schum

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