Dietary calcium affects body composition and lipid metabolism in rats

Alomaim, Haya; Griffin, Philip J.; Swist, Eleonora; Plouffe, Louise J.; Vandeloo, Michelle; Demonty, Isabelle; Kumar, Ashok; Bertinato, Jesse

doi:10.1371/journal.pone.0210760

Cited by 28 publications

(23 citation statements)

References 70 publications

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“…It seems that high intake of calcium in present study may possibly be associated with reduced risk of overweight and obesity. Apparently, the mechanism of this effect is related to the reduction of PTH and 1, 25-Dihydroxyvitamin D which leads to inhibition of lipogenesis and increase lipolysis and ultimately increase in fecal fat excretion due to the formation of soaps (45). Perhaps this is a reason for the negative relationship seen in this study.…”

Section: Discussionmentioning

confidence: 68%

Maternal dietary diversity and Nutritional adequacy in relation with anthropometric measurements of newborns at birth: a cohort study in Tehran city

Karimi

Eini-Zinab

Moslemi

et al. 2020

Preprint

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Background Maternal dietary intake during pregnancy plays an important role in fetal development and birth outcomes. The aim of the present study was to determine maternal dietary diversity and Nutritional adequacy in relation with anthropometric measurements of newborn at birth as a cohort study in Tehran city. methods This prospective cohort study, was conducted by participation of 585 pregnant women referred to public health centers and hospitals covered by Shahid Beheshti, Tehran and Iran Universities in Tehran City. Using face-to-face interviews, general characteristics were obtained by questionnaire. Pre-pregnancy dietary intake was measured by a 168-item semi-quantitative food frequency questionnaire at the first visit, and dietary intake during pregnancy was measured by 2 non-consecutive 24-hour food recall (one holiday and one regular day) at 31–34 weeks. Maternal height and weight were measured using standard tools and protocol at the first visit, and maternal weight at the end of pregnancy and data related to neonatal anthropometric indices were collected from mothers and neonates health records in the Sib electrical system. By applying SPSS software (version 23) the association was analyzed by linear regression with adjusting for confounding factors. P-value < 0.05 was considered as significant. Results Mean ± standard deviation of body mass index (BMI) of pre-pregnancy, pregnancy weight gain, BMI for age z-score (BAZ) at birth of infants were 24.52 ± 4.12, 12.16 ± 6.85 kg and − 0.61 ± 1.48, respectively. Mean ± SD of the Dietary Diversity Score (DDS) and Mean Adequacy Ratio (MAR) before and during pregnancy were 5.31 ± 1.11, vs.5.23 ± 1.42 and 289.85 ± 113.12 vs. 371.07 ± 197.28, respectively. After adjusting for confounding factors DDS in the third trimester of pregnancy was inversely correlated with WAZ (B=-0.16, 95% CI=- 0.23_0.30) and BAZ (B = -0.24, 95% CI=- 0.06_0. 42) at birth, MAR of pre-pregnancy (B = -0.001, 95% CI=- 0.002_0.00) and in the third trimester of pregnancy (B = -0.18, 95% CI=- 0.35_0.004) were negatively associated with WAZ at birth. Conclusion The findings showed that maternal nutritional status (dietary diversity and nutritional adequacy) before and during pregnancy were correlated with neonatal anthropometric indices at birth.

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Section: Discussionmentioning

confidence: 68%

Maternal dietary diversity and Nutritional adequacy in relation with anthropometric measurements of newborns at birth: a cohort study in Tehran city

Karimi

Eini-Zinab

Moslemi

et al. 2020

Preprint

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“…They explained that the low level of free fatty acid (FFA) and glycerol due to reduced lipolytic activity leads to stable serum TG levels in response to a low and very low calcium diet (He et al, 2011). Alomaim et al (2019), observed that a high calcium diet (20 Ca) having calcium concentration (20.1 ± 0.1 g Ca/ kg wet weight) lowered the serum TC and LDL-C level in comparison to rats fed with normal (5Ca) having calcium concentration (5.08 ± 0.07 g Ca/kg wet weight) or low calcium diets (0.75 Ca or 2 Ca) having concentration (0.789 ± 0.048 or 2.09 ± 0.01 g Ca/ kg wet weight) after 10 weeks of the experimental period. This improvement in the lipid profile was achieved by inhibiting the bile acid reabsorption and suppressed the absorption of neutral sterols as well as saturated and trans fatty acids in response to a high calcium diet.…”

Section: Effec T Of D Ie Tary C Alci Um On Hypertens Ionmentioning

confidence: 99%

Role of dietary calcium and its possible mechanism against metabolic disorders: A concise review

Das

Choudhuri

2021

J. Food Biochem.

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The global prevalence of metabolic disorders including hypertension, dyslipidemia, insulin resistance, nonalcoholic fatty liver, and cardiovascular diseases seemed to affect people of all ages cutting across the national, economic, and demographic barrier. Therefore, the prevention of metabolic disorders is considered of paramount importance. The dietary role of nutrients including vitamins and minerals is one of the recommended preventive measures against metabolic disorders in modern society. Recently, dietary calcium, a common nutrient not only showed a beneficial effect against obesity through weight management, but also gained great attention against the risk of metabolic disorders. Though dietary calcium shows several beneficial effects against metabolic disorders but some inconsistent results were also reported.So, the present review aims to extract recent knowledge as well as their possible underlying mechanisms regarding the role of dietary calcium against metabolic disorders. The present review also discusses the negative impact as well as prospect of calcium intake on health issues. In summary, high calcium diet prevents the harmful consequences of metabolic disorders by regulating hormonal actions, alteration in intracellular calcium level, renin-angiotensin system, intestinal fat absorption, fecal fat excretion, lipid metabolism, carbohydrate metabolism, inflammation, and oxidative stress which together improve the metabolic health of an individual. Practical applicationsMetabolic disorder is a global health issue across all sections of society and is growing rapidly in spite of several attempts by the scientific community to prevent it.Recently dietary calcium gained great attention in the last few years for its role in the management and treatment of metabolic disorders. The current review highlights the beneficial role of dietary calcium against several metabolic complications by exploring their underlying mechanisms at cellular level. This study will provide valuable information regarding the recommendation of dietary calcium in health policy as well as its inclusion in the dietary chart through calcium-rich foods and/or taking calcium supplements which can be a useful approach in preventing the risk of metabolic disorder depending on the health status of an individual.

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“…13 On the other hand, it can also exert coordinated regulatory effects on the adipocyte lipid metabolism and triacylglycerol storage by increasing the gene expressions on the lipogenic and de novo lipogenesis and inhibiting the lipolysis and thermogenesis to result in excessive lipid accumulation in the hepatic tissueand associated NAFLD. 14,15 Recently, emerging evidence has shown that the first 1,000 d in life is a critical period for the colonization of intestinal flora and prevention of many chronic non-communicable diseases (NCD) such as NAFLD. 16 Thus, keeping adequate calcium intake in this period of the life is of a great importance for a positive calcium balance, good bone density necessary for the skeletal consolidation, and reducing the occurrence of NCD in the later.…”

Section: Introductionmentioning

confidence: 99%

Sex-specific maternal calcium requirements for the prevention of nonalcoholic fatty liver disease by altering the intestinal microbiota and lipid metabolism in the high-fat-diet-fed offspring mice

Yan

Chang

et al. 2020

Gut Microbes

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The significance of maternal appropriate calcium intakes for energy metabolism in the offspring has been recognized. Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome. So in this study, we proposed that there were long-term effects of maternal calcium status on the progress of NAFLD by altering the intestinal microbiota and lipid metabolism with attention to potential sex differences among the mouse offspring. Thirty-fourweek female C57BL/6 J mice were subjected to obtain low, normal and high calcium reproductive diets throughout the gestation and lactation. After weaning, both the male and female mouse offspring were fed with the high-fat diet for 16 weeks, with the normal diet as control. Biochemical indicators in the plasma and hepatic tissue were measured using ELISA or enzymatic methods. The expression of lipid metabolism, inflammatory and fibrosis related genes was determined by RT-PCR. The intestinal microbiota was analyzed by 16S rRNA high-throughput sequencing. Maternal normal and low calcium intake could, respectively, inhibit the progress of high-fat diet induced NAFLD in the male and female mouse offspring, which was characterized by the least lipid droplets, inflammatory infiltration and fibrosis, the lowest concentrations of free fatty acids and triglyceridethe lowest expression of genes involving in de novo lipogenesis and the highest expression of genes related to lipid oxidation and hydrolysis, inflammatory, and fibrosis. Pyrosequencing of 16S rRNA genes revealed that the male mouse offspring with maternal normal calcium intake and the female mouse offspring with maternal low calcium intake, after the high-fat diet feeding, had distinct intestinal microbiota, which was closer to thosein mice with the normal diet feeding. Analysis of the functional features for the different microbiota was compatible with the expression of genes associated with lipogenesis, lipid oxidation and hydrolysis. Thus, there is a sex-specific manner for maternal calcium requirement to inhibit the progress of offspring NAFLD, that might be less for the female offspring and more for the male offspring.

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Dietary calcium affects body composition and lipid metabolism in rats

Cited by 28 publications

References 70 publications

Maternal dietary diversity and Nutritional adequacy in relation with anthropometric measurements of newborns at birth: a cohort study in Tehran city

Maternal dietary diversity and Nutritional adequacy in relation with anthropometric measurements of newborns at birth: a cohort study in Tehran city

Role of dietary calcium and its possible mechanism against metabolic disorders: A concise review

Sex-specific maternal calcium requirements for the prevention of nonalcoholic fatty liver disease by altering the intestinal microbiota and lipid metabolism in the high-fat-diet-fed offspring mice

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