Dietary Caffeine and Polyphenol Supplementation Enhances Overall Metabolic Rate and Lipid Oxidation at Rest and After a Bout of Sprint Interval Exercise

Abstract

Jo, E, Lewis, KL, Higuera, D, Hernandez, J, Osmond, AD, Directo, DJ, and Wong, M. Dietary caffeine and polyphenol supplementation enhances overall metabolic rate and lipid oxidation at rest and after a bout of sprint interval exercise. J Strength Cond Res 30(7): 1871-1879, 2016-The purpose of this study was to investigate the effects of a caffeine-polyphenolic supplement on (a) metabolic rate and fat oxidation at rest and after a bout of sprint interval exercise (SIE) and (b) SIE performance. In a double-blind, randomized, placebo-controlled, crossover study and after an initial familiarization visit, 12 subjects (male: n = 11; female: n = 1) (body mass = 76.1 ± 2.2 kg; height = 169.8 ± 1.6 cm; body mass index = 22.7 ± 3.0 kg·m; body fat % = 21.6 ± 2.0%) underwent 2 testing sessions during which time they consumed either a caffeine-polyphenol supplement or placebo. After supplementation, resting energy expenditure, heart rate (HR), and blood pressure (BP) were assessed. Subsequently, subjects performed 30 minutes of SIE while researchers collected performance data. Subjects were then tested for post-SIE energy expenditure, HR, and BP. The caffeine-polyphenol treatment resulted in significantly (p ≤ 0.05) greater energy expenditure (+7.99% rest; +10.16% post-SIE), V[Combining Dot Above]O2 (+9.64% rest; +12.10% post-SIE), and fat oxidation rate (+10.60% rest; +9.76% post-SIE) vs. placebo at rest and post-SIE. No significant differences were detected for peak and average power at all sprint intervals between treatments. Post-SIE HR was significantly (p ≤ 0.05) greater with caffeine-polyphenol supplementation vs. placebo (90.8 ± 3.5 vs. 85.1 ± 3.6 b·min). There were no significant between-treatment differences for BP. It may be concluded that the observed thermogenic response after SIE was directly attributable to caffeine-polyphenol supplementation as opposed to an indirect manifestation of enhanced performance and work output. Collectively, these results corroborate the use of dietary caffeine and polyphenols to support efforts to reduce adiposity and improve overall body composition especially in conjunction with SIE.

Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice

“…However, weight loss observed with yerba maté consumption has been previously attributed to the caffeine content of the tea, which has been demonstrated to make up 1-2% of the dry leaf weight [38]. As a stimulant, caffeine has been shown to increase basal metabolic rate, improve aerobic performance and muscle oxygen content during exercise tests [39], and increase lipid oxidation [40,41]. Additionally, caffeine has been reported to increase the in vivo and in vitro expression of adipose UCP1 (uncoupling protein 1), a mitochondrial uncoupling protein that releases energy stored in the mitochondrial proton gradient in the form of heat in brown adipose [42].…”

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

“…In Brazil, caffeine has been found in other nutritional supplements marketed for weight loss and physical fitness ( Viana et al., 2016 ). Caffeine is, perhaps, the most researched thermogenic or ergogenic substance, and has been reported to significantly increase total daily energy expenditure, facilitate body fat reduction, improve alertness, and enhance physical performance ( Jo et al., 2016 ; Ratamess et al., 2016 ; Clark et al., 2019 ; Kliszczewicz et al., 2019 ).…”

“…Since then, new products such as "ephedrine-free" dietary supplements have been introduced in the world market. Although these supplements are not supposed to contain ephedrine alkaloids, they often incorporate various sources of caffeine and other botanical extracts whose compounds exhibit pharmacological activities including fat oxidation and increased total daily energy expenditure, promoting body fat reduction (e.g., p -synephrine, forskolin, and yohimbine) ( Gurley et al., 2015 ; Gutiérrez-Hellín and Del Coso, 2016 ; Jo et al., 2016 ).…”

Does Caffeine Increase Fat Metabolism? A Systematic Review and Meta-Analysis

“…Thus, despite two meta-analyses on the topic, the fat metabolic theory as a physiological effect of CAF during exercise remains debatable. Several studies have also reported enhanced fat metabolism after consuming CAF under resting conditions (Acheson et al, 2004;Bellet et al, 1965Bellet et al, , 1968Jo et al, 2016), suggesting the metabolic equivalent of tasks level (from rest to lowintensity exercise) may be an important mediating factor. Moreover, the methods used to assess fat metabolism vary, with some studies reporting blood biomarkers of lipolysis and others relying exclusively on whole-body gas exchange data.…”