Dietary Boron is a Physiological Regulator of the Normal Inflammatory Response

Hunt, Curtiss D.

doi:10.1007/0-306-47466-2_327

Cited by 10 publications

(6 citation statements)

References 13 publications

(10 reference statements)

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“…In the literature, there is emerging research showing that boric acid enhances the elimination of ROS, which are scavenged by catalase, glutathione, and superoxide dismutase. 44 The decreased amount of ROS was observed when the cells were treated with a low concentration of borate/boric acid solution. 45 The improved decrease in ROS level in hBNstreated cells is perhaps due to the slow release of boron content from hBNs.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Stimulatory Effect of Hexagonal Boron Nitrides in Wound Healing

Şen

Emanet

Çulha

2019

ACS Appl. Bio Mater.

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There is an increased interest in the use of hexagonal boron nitrides (hBNs) in medicine due to their unique properties that include low toxicity, absorption of UV light and neutrons, high chemical stability, and mechanical strength. In this study, hBNs were investigated for wound healing therapy as a potential therapeutic agent. Boron compounds (especially boric acid) are increasingly used in wound healing therapy; however, their short half-life is a bottleneck and limits their use. Because hBNs slowly degrade and one of the degradation products is boric acid (BA), hBNs and BA were comparatively evaluated in vitro to assess their influence on wound healing. First, antimicrobial activity and cytotoxicity of synthesized hBNs were evaluated for dose determination. Then, the results of scratch assay indicated that hBNs accelerated the wound closure at low concentrations, showing also enhanced angiogenic activity compared to BA. The cell cycle analysis showed that hBNs did not arrest the cells in the G2/M phase but induced the cells to go into S phase, whereas BA had almost no effect on the cell proliferation. It was also found that the hBNs decreased the reactive oxygen species level more than BA. Apoptosis/necrosis assay showed that the hBNs rescued the cells from apoptosis, whereas BA had almost no effect on the cell death mechanism. Beside, hBNs did not cause damage to the mitochondria at low concentration and did not perturb the F-actin conformation at all tested concentrations. These findings suggest that hBNs might be a potential therapeutic agent in wound healing therapy.

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Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Stimulatory Effect of Hexagonal Boron Nitrides in Wound Healing

Şen

Emanet

Çulha

2019

ACS Appl. Bio Mater.

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“…Furthermore, the possible anti-inflammatory properties of dietary boron [ 129 ] should also be considered in the light of the above considerations. In principal, proteinase-inhibiting peroxoborate could be generated from ingested borate in vivo via its interaction with phagocytically-generated H 2 O 2 at sites of inflammation, including those in selected oral environments (Equation (1)).…”

Section: Specificity Of the Inhibition Of Proteinase Enzymes By Pmentioning

confidence: 99%

“…Since this area is beyond the scope of this paper, readers are referred to Ref. [ 129 ], and references available therein.…”

Section: Specificity Of the Inhibition Of Proteinase Enzymes By Pmentioning

confidence: 99%

Potential Advantages of Peroxoborates and Their Ester Adducts Over Hydrogen Peroxide as Therapeutic Agents in Oral Healthcare Products: Chemical/Biochemical Reactivity Considerations In Vitro, Ex Vivo And In Vivo

et al. 2020

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Peroxides present in oral healthcare products generally exert favourable protective activities against the development and progression of tooth decay, plaque, gingivitis, and halitosis, etc. However, despite the high level of research focus on hydrogen and carbamide peroxides as therapeutically active (and tooth-whitening) agents, to date the use of alternative chemical forms of peroxides such as peroxoborates for these purposes has received only scant attention. Intriguingly, peroxoborate and its esters with polyols, such as glycerol, have a very diverse chemistry/biochemistry in aqueous solution, for which there is an increasing amount of evidence that it remains distinctive from that of hydrogen peroxide; such properties include self-associative and hydrolytic equilibria, and their abilities to participate in electrophile- or nucleophile-scavenging, metal ion-complexing, redox and free radical reactions, for example. Therefore, the purpose of this detailed commentary is to evaluate both differences and similarities between the molecular/biomolecular reactivities of peroxoborate species and hydrogen peroxide in vitro, ex-vivo and in vivo. It encompasses brief sectional accounts regarding the molecular heterogeneity of peroxoborates, the release of bioactive agents therefrom, and their oxidative attack on oral cavity biomolecules (the nucleophilic or electrophilic character of these oxidations are discussed). Further areas explored are the abilities of borates and peroxoborates to enhance the solubility of iron ions in aqueous solution, their involvements in free radical biochemistry (particularly the complexation of oxygen radical-promoting transition metal ions by, and antioxidant properties of, peroxoborate-polyol ester adducts), and the specific inhibition of protease enzymes. Further aspects focus on the tooth-whitening, oral malodor neutralizing, and potential mutagenic and genotoxic properties of peroxoborates, along with possible mechanisms for these processes. The abilities of peroxoborates, and peroxides in general, to modulate the activities of inflammatory mediators and vitamins, antioxidant or otherwise, are also explored.

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“…Hayvan ve hücre kültürü çalışmaları borun artritik koşullarda olduğu gibi inflamatuar stresi inhibe edebildiğini göstermiştir. Artrit oluşturmaya yönelik "Mikobakteriyum Bütirikum"un intradermal enjeksiyonunu takiben sıçanlarda şiddetli pençe şişmesi görülme sıklığı, diyette 0,1 mg/kg ile beslenen sıçanlara kıyasla diyette 2,1 mg/kg bor ile beslenen sıçanlarda daha az görülmüştür (21).…”

Section: Bor Ve İnsan Sağlığı üZerine Etkisiunclassified

Bor'un İnsan Sağlığı ve Beslenme Üzerine Etkisi

Eseceli

Aydın

Gönen

2018

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi

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The richest sources of boron mineral in Turkey, it is known that several metabolic and biochemical effects on human health. Boron is an essential trace element for humans and many species found in nature. Boron from the soil to the plants, plants are also passed on to people through nutrition. Many abnormalities are seen in the human body together with excessive or incomplete consumption of boron mineral. Boron calcium metabolism affects the brain development, hormonal system and cancer cells, especially bones, immunity system. It is also known that boron affects the gastrointestinal system and mineral metabolism. Studies have shown that inadequate boron intake can lead to impaired bone health, increased risk of osteoporosis, impaired brain function and impaired immune response. The richest sources are herbaceous boron; most of them are found in nuts, legumes, fruits and vegetables. In both animal and human studies, less than 1.0 mg of boron per day has been shown to have no beneficial effects on tuberculosis. For this reason, proper amount of boron should be emphasized. In this review, it is aimed to summarize the literature review and its effect on human health.

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Dietary Boron is a Physiological Regulator of the Normal Inflammatory Response

Cited by 10 publications

References 13 publications

Stimulatory Effect of Hexagonal Boron Nitrides in Wound Healing

Stimulatory Effect of Hexagonal Boron Nitrides in Wound Healing

Potential Advantages of Peroxoborates and Their Ester Adducts Over Hydrogen Peroxide as Therapeutic Agents in Oral Healthcare Products: Chemical/Biochemical Reactivity Considerations In Vitro, Ex Vivo And In Vivo

Bor'un İnsan Sağlığı ve Beslenme Üzerine Etkisi

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