Dietary bile acids promote sterol metabolism, bile acids enterohepatic circulation, and apoptosis in juvenile Pacific white shrimp (Litopenaeus vannamei)

Li, Xiaoyue; Li, Haoming; Qu, Kangyuan; Liu, Yucheng; Chi, Shuyan; Yang, Qihui; Tan, Beiping; Zhang, Shuang; Xie, Shiwei

doi:10.1016/j.anifeedsci.2023.115710

Cited by 5 publications

(1 citation statement)

References 60 publications

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“…Similar to our results, a low fishmeal diet supplemented with CDCA can improve the growth performance and intestinal health of L. vannamei [32], and dietary supplementation of CDCA can also improve the hepatopancreas health of L. vannamei [1]. The growth of L. vannamei can be stimulated through dietary supplementation of 0.02-0.03% bile acid, as reported by Su et al [27].…”

Section: Discussionsupporting

confidence: 90%

Effects of Dietary Chenodeoxycholic Acid Supplementation in a Low Fishmeal Diet Containing Clostridium autoethanogenum Protein on Growth, Lipid and Cholesterol Metabolism, and Hepatopancreas Health of Litopenaeus vannamei

Shi

Zheng

Sun

et al. 2023

Animals

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The study aimed to assess the impact of adding chenodeoxycholic acid (CDCA) to the diet of Litopenaeus vannamei on their growth performance, lipid and cholesterol metabolism, and hepatopancreas health while being fed a low fishmeal diet. Five diets were formulated, one of which contained 25% fishmeal (PC); fishmeal was partially replaced with Clostridium autoethanogenum protein in the remaining four diets and supplemented with 0, 0.03, 0.06, and 0.09% CDCA (NC, BA1, BA2, and BA3, respectively). In this study, four replicates of each diet were assigned and each replicate consisted of 30 shrimp with an average weight of (0.25 ± 0.03 g). The shrimp were fed four times a day for a period of 56 days. The results of this study indicate that the inclusion of CDCA in the diet had a positive impact on the growth performance of the shrimp. The final body weight (FBW), weight gain (WG), and specific growth rate (SGR) of the shrimp in the PC group were similar to those in the BA2 group, and significantly higher than those in the other three groups. The survival rate (SR) was similar among all groups. In comparison to the PC group, the low fishmeal groups exhibited a significant decrease in the crude lipid content of the whole shrimp, as well as the Total cholesterol (T-CHOL), Low-density lipoprotein (LDL-C), and High-density lipoprotein (HDL-C) levels in the hemolymph. Regarding the sterol metabolism, the dietary supplementation of CDCA up-regulated the mRNA expression of intracellular cholesterol transporter 1-like (npc1), 7-dehydrocholesterol reductase (7dhcr), Delta (24) sterol reductase (Δ24), HMG-CoA reductase membrane form (hmgcr), and sterol carrier protein 2 (scp). In the lipid metabolism, the mRNA expression of sterol-regulatory element binding protein (srebp) was significantly down-regulated in the shrimp fed the BA1 diet and the expression of AMP-activated protein kinase (ampk) was significantly up-regulated in the shrimp fed the BA1 and BA3 diets compared to the PC group. The mRNA expression of triacylglycerol lipase (tgl) was significantly up-regulated in the shrimp fed the BA2 diet compared to the NC group. Compared with the shrimp fed the PC diets, the dietary supplementation of CDCA significantly down-regulated the protein expression of SREBP1. The lumen damage in the BA1 group was significantly less severe than those in the NC group. The addition of 0.06% CDCA to low fishmeal diets can improve the growth performance, lipid and cholesterol metabolism, and hepatopancreas health of L. vannamei.

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Section: Discussionsupporting

confidence: 90%

Effects of Dietary Chenodeoxycholic Acid Supplementation in a Low Fishmeal Diet Containing Clostridium autoethanogenum Protein on Growth, Lipid and Cholesterol Metabolism, and Hepatopancreas Health of Litopenaeus vannamei

Shi

Zheng

Sun

et al. 2023

Animals

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Effects of taurine supplementation in low fishmeal diet on growth, immunity and intestinal health of Litopenaeus vannamei

Shi,

Yao,

et al. 2023

Aquaculture Reports

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Effectiveness of bile acids as a feed supplement to improve growth performance, feed utilization, lipid metabolism, digestive enzymes, and hepatic antioxidant status in aquaculture animals: A meta-analysis

Dietary bile acids promote sterol metabolism, bile acids enterohepatic circulation, and apoptosis in juvenile Pacific white shrimp (Litopenaeus vannamei)

Cited by 5 publications

References 60 publications

Effects of Dietary Chenodeoxycholic Acid Supplementation in a Low Fishmeal Diet Containing Clostridium autoethanogenum Protein on Growth, Lipid and Cholesterol Metabolism, and Hepatopancreas Health of Litopenaeus vannamei

Effects of Dietary Chenodeoxycholic Acid Supplementation in a Low Fishmeal Diet Containing Clostridium autoethanogenum Protein on Growth, Lipid and Cholesterol Metabolism, and Hepatopancreas Health of Litopenaeus vannamei

Effects of taurine supplementation in low fishmeal diet on growth, immunity and intestinal health of Litopenaeus vannamei

Effectiveness of bile acids as a feed supplement to improve growth performance, feed utilization, lipid metabolism, digestive enzymes, and hepatic antioxidant status in aquaculture animals: A meta-analysis

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