Dietary bile acids improve breast muscle growth in chickens through FXR/IGF2 pathway

Chen, Liang; Shi, Yanghong; Li, Jinbao; Shao, Caimei; Ma, Shuai; Shen, Chao; Zhao, Ruqian

doi:10.1016/j.psj.2023.103346

Cited by 2 publications

(2 citation statements)

References 43 publications

(52 reference statements)

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“…In our study, antibiotic treatment reduced IGF-1 and IGF-2 levels in the serum and liver of rats; this was accompanied by a significant reduction in FXR binding to the fragment of the IGF-2 gene promoter region. Similar to our previous findings, dietary bile acid supplementation improves breast muscle growth in broilers fed a high-fat diet, through the FXR-mediated IGF-2 pathway [ 13 ]. Therefore, we speculate that the growth-regulating IGF-2 gene is regulated by the bile acid nuclear receptor FXR in the liver.…”

Section: Discussionsupporting

confidence: 90%

“…Bile acids are crucial metabolites of the gut microbiota and act as signaling molecules to regulate body growth and feeding, binding to glucose-dependent insulinotropic receptor 119 (GPR119) and G-protein-coupled bile acid receptor (TGR5) in the gastrointestinal tract to regulate the secretion of appetite-related hormones such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) [ 8 , 12 ]. Additionally, dietary bile acid supplementation increases breast muscle growth by increasing FXR protein expression and binding to the IGF-2 promoter in broilers [ 13 ]. Nevertheless, the specific impact of gut microbiota on growth through the modulation of the bile acid nuclear receptor FXR remains to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic-Induced Gut Microbial Dysbiosis Reduces the Growth of Weaning Rats via FXR-Mediated Hepatic IGF-2 Inhibition

Wang,

Ma,

Zhao

et al. 2024

Nutrients

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The gut microbiota plays a crucial role in postnatal growth, particularly in modulating the development of animals during their growth phase. In this study, we investigated the effects of antibiotic-induced dysbiosis of the gut microbiota on the growth of weaning rats by administering a non-absorbable antibiotic cocktail (ABX) in water for 4 weeks. ABX treatment significantly reduced body weight and feed intake in rats. Concurrently, ABX treatment decreased microbial abundance and diversity in rat ceca, predominantly suppressing microbes associated with bile salt hydrolase (BSH) activity. Furthermore, decreased appetite may be attributed to elevated levels of glucagon-like peptide-1 (GLP-1) in the serum, along with reduced neuropeptide Y (NPY) and increased cocaine and amphetamine-regulated transcript (CART) in the hypothalamus at the mRNA level. Importantly, concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 2 (IGF-2) were decreased in the serum and liver of antibiotic-treated rats. These alterations were associated with significant down-regulation of IGF-2 mRNA in the liver and significantly decreased farnesoid X receptor (FXR) protein expression and binding to the IGF-2 promoter. These results indicate that antibiotic-induced gut microbial dysbiosis not only impacts bile acid metabolism but also diminishes rat growth through the FXR-mediated IGF-2 pathway.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Antibiotic-Induced Gut Microbial Dysbiosis Reduces the Growth of Weaning Rats via FXR-Mediated Hepatic IGF-2 Inhibition

Wang,

Ma,

Zhao

et al. 2024

Nutrients

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Dietary bile acids supplementation decreases hepatic fat deposition with the involvement of altered gut microbiota and liver bile acids profile in broiler chickens

Wang,

Li,

Jiao

et al. 2024

J Animal Sci Biotechnol

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Background High-fat diets (HFD) are known to enhance feed conversion ratio in broiler chickens, yet they can also result in hepatic fat accumulation. Bile acids (BAs) and gut microbiota also play key roles in the formation of fatty liver. In this study, our objective was to elucidate the mechanisms through which BA supplementation reduces hepatic fat deposition in broiler chickens, with a focus on the involvement of gut microbiota and liver BA composition. Results Newly hatched broiler chickens were allocated to either a low-fat diet (LFD) or HFD, supplemented with or without BAs, and subsequently assessed their impacts on gut microbiota, hepatic lipid metabolism, and hepatic BA composition. Our findings showed that BA supplementation significantly reduced plasma and liver tissue triglyceride (TG) levels in 42-day-old broiler chickens (P < 0.05), concurrently with a significant decrease in the expression levels of fatty acid synthase (FAS) in liver tissue (P < 0.05). These results suggest that BA supplementation effectively diminishes hepatic fat deposition. Under the LFD, BAs supplementation increased the BA content and ratio of Non 12-OH BAs/12-OH BAs in the liver and increased the Akkermansia abundance in cecum. Under the HFD, BA supplementation decreased the BAs and increased the relative abundances of chenodeoxycholic acid (CDCA) and cholic acid (CA) in hepatic tissue, while the relative abundances of Bacteroides were dramatically reduced and the Bifidobacterium, Escherichia, and Lactobacillus were increased in cecum. Correlation analyses showed a significant positive correlation between the Akkermansia abundance and Non 12-OH BA content under the LFD, and presented a significant negative correlation between the Bacteroides abundance and CA or CDCA content under the HFD. Conclusions The results indicate that supplementation of BAs in both LFD and HFD may ameliorate hepatic fat deposition in broiler chickens with the involvement of differentiated microbiota–bile acid profile pathways. Graphical Abstract

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Dietary bile acids improve breast muscle growth in chickens through FXR/IGF2 pathway

Cited by 2 publications

References 43 publications

Antibiotic-Induced Gut Microbial Dysbiosis Reduces the Growth of Weaning Rats via FXR-Mediated Hepatic IGF-2 Inhibition

Antibiotic-Induced Gut Microbial Dysbiosis Reduces the Growth of Weaning Rats via FXR-Mediated Hepatic IGF-2 Inhibition

Dietary bile acids supplementation decreases hepatic fat deposition with the involvement of altered gut microbiota and liver bile acids profile in broiler chickens

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