Dietary berries, insulin resistance and type 2 diabetes: an overview of human feeding trials

Abstract

This review focuses on the role of dietary berries, especially the commonly consumed blueberries, cranberries and strawberries on metabolic syndrome and type 2 diabetes in human trials.

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

“…Anthocyanins have shown antioxidant and anti-inflammatory properties but also positive effects in obesity and its comorbidities [ 57 , 58 , 59 , 60 ]. Several studies have demonstrated that the intake of anthocyanins by itself or of anthocyanins-rich foods such as berries is able to prevent CVD [ 61 ], to reduce body fat accumulation, to improve glucose tolerance/insulin sensitivity, to diminish the levels of fasting glucose, to control body weight in humans and rodents [ 57 , 59 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ] and to increase energy expenditure and fatty acid oxidation (FAO) in mice and humans [ 59 , 73 , 74 , 75 , 76 ]. Globally, anthocyanins and anthocyanins-rich foods are able to improve metabolic homeostasis.…”

Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-Associated Complications: A Systematic Review of Preclinical Studies

“…Food-derived bioactive compounds are increasingly explored for their ameliorative effects against metabolic diseases. For example, our group and others have extensively examined the beneficial effects of rooibos tea, including its bioactive compounds such as aspalathin, as well as other pharmacological compounds with abundant antioxidant properties like berries, n-acetyl cysteine, and gallic acid against diverse metabolic disorders [16][17][18][75][76][77][78][79][80]. Consistently, an extensive literature has been reviewed on the impact of resveratrol in ameliorating metabolic disease-associated complications [20,66,67].…”

“…All included animal studies in this systematic review met the minimum requirements for publication using the ARRIVE guidelines checklists with 20 questions. Briefly, the median score range of all included studies was 15 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) out of a possible score of 20. The introduction domain had a median score of 4 (4-4) out of the possible score of 4 (overall agreement 100%, kappa = 1) whilst the methods domain had a median score of 6 (2-9) out of a possible score of 9 (overall agreement 88.89%, kappa = 0.76).…”

“…Alternatively, there has been great interest in exploring nutritional food products, including plant derived-bioactive compounds, for their ameliorative effects against diabetes-associated complications. For example, regular intake of tea or fruits, due to their rich source of several nutrients and phytochemicals, has been associated with reduced risk of several chronic diseases, including obesity and diabetes [16][17][18]. Consistently, evidence from a meta-analysis of randomized controlled trials (RCTs) has shown that supplementation with resveratrol could effectively improve fasting plasma glucose and insulin levels [19].…”

Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?

“…The constellation of risk factors of the metabolic syndrome, including dyslipidemia, insulin resistance, hypertension, and obesity, responds advantageously to polyphenols ( Fig. 6 ) ( 24 ). Consistent antidiabetic and cardioprotective effects are observed following administration of polyphenolic flavonoid experimental models and human studies ( 11 , 111 , 214 ).…”