Dietary astaxanthin enhances immune response in dogs

Chew, Boon P.; Mathison, Bridget; Hayek, Michael G.; Massimino, Stefan; Reinhart, Gregory A.; Park, Jean Soon

doi:10.1016/j.vetimm.2010.12.004

Cited by 79 publications

(61 citation statements)

References 27 publications

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“…enhanced with any enriched diet while the superoxide anion significantly enhanced in 50 and 100 mg kg À1 diets on weeks 2 and 4 against pathogen. Thus the present study indicate that astaxanthin supplementation in diet might have induced other antimicrobial mechanisms, which include release of lysosomal enzymes, cationic peptides, complement components and production of reactive oxygen species [63,64,67]. The astaxanthin-actomyosin ratio in coho salmon muscle was nearly 100 mg astaxanthin per kg flesh [39], was indicated for salmonid fishes [40], which is comparable to the highest levels (59 mg astaxanthin kg À1 muscle) reported for wild sockeye salmon [41].…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary astaxanthin against Aeromonas hydrophila infection in common carp, Cyprinus carpio

Jagruthi

Yogeshwari

Anbazahan

et al. 2014

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

Effect of dietary astaxanthin against Aeromonas hydrophila infection in common carp, Cyprinus carpio

Jagruthi

Yogeshwari

Anbazahan

et al. 2014

Fish & Shellfish Immunology

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“…Actual demonstrated non-vitamin A health benefits of carotenoids in animals point to involvement of immune function [2], [10], [11], [12], [13], [14]. It has been suggested carotenoids can participate in and modulate processes involving reactive oxygen species [2], [3], [12].…”

Section: Introductionmentioning

confidence: 99%

Biologically Active Polymers from Spontaneous Carotenoid Oxidation: A New Frontier in Carotenoid Activity

Johnston¹,

Nickerson

Daroszewski³

et al. 2014

PLoS ONE

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In animals carotenoids show biological activity unrelated to vitamin A that has been considered to arise directly from the behavior of the parent compound, particularly as an antioxidant. However, the very property that confers antioxidant activity on some carotenoids in plants also confers susceptibility to oxidative transformation. As an alternative, it has been suggested that carotenoid oxidative breakdown or metabolic products could be the actual agents of activity in animals. However, an important and neglected aspect of the behavior of the highly unsaturated carotenoids is their potential to undergo addition of oxygen to form copolymers. Recently we reported that spontaneous oxidation of ß-carotene transforms it into a product dominated by ß-carotene-oxygen copolymers. We now report that the polymeric product is biologically active. Results suggest an overall ability to prime innate immune function to more rapidly respond to subsequent microbial challenges. An underlying structural resemblance to sporopollenin, found in the outer shell of spores and pollen, may allow the polymer to modulate innate immune responses through interactions with the pattern recognition receptor system. Oxygen copolymer formation appears common to all carotenoids, is anticipated to be widespread, and the products may contribute to the health benefits of carotenoid-rich fruits and vegetables.

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“…Increased intake of dietary carotenoids has been associated with various immune function benefits, including increased cell-mediated and humoral immune responsiveness and decreased DNA damage and inflammation (e.g., Chew et al 2011). However, the specific effects of carotenoids on the immune response vary with type of carotenoid, dosage, and species studied (Chew and Park 2004).…”

Section: Introductionmentioning

confidence: 99%

Carotenoid-Based Ornaments of Female and Male American Goldfinches (Spinus tristis) Show Sex-Specific Correlations with Immune Function and Metabolic Rate

Kelly¹,

Murphy²,

Tarvin³

et al. 2012

Physiological and Biochemical Zoology

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Conspicuous ornamentation has been linked to immunological and physiological condition in males of many species. In species where both sexes are ornamented, it is unclear whether the signal content of ornaments differs between males and females. We examined the immunological and physiological correlates of carotenoid-based bill and plumage ornamentation in American goldfinches Spinus tristis, a species in which bright orange bills are sexually monomorphic but yellow plumage is sexually dimorphic during the breeding season. Because bill color is dynamic over short periods while plumage color is static over longer time frames, we tested whether these signals have the potential to provide temporal information about immunity and condition. In both sexes, bill color (but not plumage color) was negatively related to leukocyte differential, a measure of recent stress, while plumage color (but not bill color) was positively related to resting metabolic rate. In females, bill color also positively correlated with immunoglobulin Y, a component of acquired immunity, while plumage color positively predicted natural antibody levels, a component of innate immunity. In males, neither bill color nor plumage color predicted immune function, suggesting that the mechanisms underlying these signals vary with sex. Our results demonstrate that dynamic signals such as bill coloration do not merely reflect the same information provided by static signals but that these two classes of signal provide information about different temporal aspects of phenotypic quality. Furthermore, our results indicate that a signal expressed in both sexes has the potential to provide different information depending on the sex of the bearer.

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Dietary astaxanthin enhances immune response in dogs

Cited by 79 publications

References 27 publications

Effect of dietary astaxanthin against Aeromonas hydrophila infection in common carp, Cyprinus carpio

Effect of dietary astaxanthin against Aeromonas hydrophila infection in common carp, Cyprinus carpio

Biologically Active Polymers from Spontaneous Carotenoid Oxidation: A New Frontier in Carotenoid Activity

Carotenoid-Based Ornaments of Female and Male American Goldfinches (Spinus tristis) Show Sex-Specific Correlations with Immune Function and Metabolic Rate

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