Dietary Antioxidants and Cognitive Function in a Population-based Sample of Older Persons: The Rotterdam Study

Jama, Jalius; Launer, Lenore J.; Witteman, J. C. M.; Breeijen, J.H. den; Breteler, Monique M.B.; Grobbee, D. E.; Hofman, Albert

doi:10.1093/oxfordjournals.aje.a008922

Cited by 230 publications

(142 citation statements)

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“…To our knowledge, a cocktail intervention similar to the one used in our studies has not been examined in human aging. Although some positive results have been reported in clinical trials examining the effects of Vitamins E and C (Di Matteo and Esposito 2003) and antioxidant supplements (Grodstein et al 2003;Jama et al 1996;Engelhart et al 2002;Helmer et al 2003;Zandi et al 2004) on several aspects of aging (McDaniel et al 2003;Martin 2003;Martin et al 2002), the studies reported here suggest that a cocktail intervention consisting of several antioxidants and mitochondrial cofactors may be more effective, possibly due to a synergistic effect. Similarly, studies in humans (Grodstein et al 2003;Zandi et al 2004;Masaki et al 2000) and rodents (Joseph et al 1998(Joseph et al , 1999Bickford et al 2000) suggest that combination antioxidant therapy may be more effective than single component supplementation.…”

Section: Antioxidants and Mitochondrial Cofactorsmentioning

confidence: 56%

Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging

Araujo

Studzinski

Head

et al. 2005

AGE

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The present review focuses on the utility of a canine model in evaluating nutritional interventions for age-related cognitive dysfunction. Aged dogs demonstrate progressive cognitive decline with concurrent amyloid-beta pathology that parallels the pathology observed in aging humans. Dogs, therefore, provide a natural model of human pathological aging. We have and are in the process of evaluating several nutritional-based interventions aimed at preventing cognitive decline and brain aging. In a three-year longitudinal study, we examined the effects of a diet enriched with antioxidants and mitochondrial cofactors on several measures of cognition and brain aging. Compared to controls, aged dogs on the enriched diet demonstrated both short-and long-term cognitive benefits, as well decreased deposition of amyloid-beta protein. The diet also reduced behavioral signs associated with canine Cognitive Dysfunction Syndrome when assessed in veterinary clinical trials. We also have preliminary evidence suggesting a beneficial effect of a proprietary blend of docosahexaenoic acid and phospholipids on both cognitive and physiological measures. Collectively, our data indicate (1) that the dog, either in the laboratory or in the clinic, provides an important tool for assessing nutritional interventions and (2) that combination interventions aimed at several mechanisms of pathological aging may prove more effective than single nutritive components in human trials.

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Section: Antioxidants and Mitochondrial Cofactorsmentioning

confidence: 56%

Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging

Araujo

Studzinski

Head

et al. 2005

AGE

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“…The vitamins that play a substantial role in the immunity of the elderly include vitamins A, C, D, E and B6; the minerals affecting immune function include zinc and iron (Kelley & Bendich, 1996;Bell & High, 1997). Suggestive rather than conclusive studies have indicated an association between cognitive function impairment in the elderly and a deficient intake of micronutrients, especially folate, vitamins C and E, b-carotene, zinc and iron (Warsama et al, 1996;Ortega et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Dietary and nutritional patterns in an elderly rural population in Northern and Southern Italy: (II). Nutritional profiles associated with food behaviours

et al. 2003

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Objective: To describe the nutritional profiles of the food consumption patterns identified in an elderly Italian rural population. Design: Cross-sectional study. Setting: Population-based study. Subjects: A total of 847 men and 1465 women aged 65 y or older, resident in rural areas in the province of Pavia (Northern Italy) and near Cosenza (Southern Italy) in 1992-1993. Interventions: A cluster analysis segregated the subjects into six groups for men and seven for women on the basis of similarities in their food intake (see companion paper). The mean daily energy, macronutrient, mineral and vitamin intakes were calculated for the sample as a whole and for each cluster, and then compared with the age-and gender-specific recommended daily allowances for the Italian population. Results: The largest cluster ('small eaters', which included about half of the population) had an insufficient intake of essential fatty acids, calcium, potassium, zinc (men), iron (women), thiamin, riboflavin, niacin, b-carotene, and vitamins A, D and E. The most noticeable characteristics of some of the other clusters were a high intake of fats, a high proportion of total energy provided by sugars, a high intake of vitamin C, folic acid and b-carotene, and a high alcohol consumption. Furthermore, sodium intake was too high in all of the clusters and vitamin D intake was generally inadequate. Conclusions: The dietary habits of elderly Italians living in rural areas combine elements of the Mediterranean and 'wealthy' diets.

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“…One of the relevant environmental factors seems to be food. There is a growing awareness that food may play a role in determining not only our physical well-being, but also our behaviour and cognitive functioning [6][7][8]. The role of food in ADHD has been investigated since 1985 in several restricted elimination diet (RED) studies.…”

mentioning

confidence: 99%

Is there a future for restricted elimination diets in ADHD clinical practice?

Rommelse¹,

Buitelaar²

2013

Eur Child Adolesc Psychiatry

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Dietary Antioxidants and Cognitive Function in a Population-based Sample of Older Persons: The Rotterdam Study

Cited by 230 publications

References 0 publications

Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging

Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging

Dietary and nutritional patterns in an elderly rural population in Northern and Southern Italy: (II). Nutritional profiles associated with food behaviours

Is there a future for restricted elimination diets in ADHD clinical practice?

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