Dietary antioxidants and beneficial effect on oxidatively damaged DNA

Möller, Peter; Loft, Steffen

doi:10.1016/j.freeradbiomed.2006.04.001

Cited by 127 publications

(64 citation statements)

References 188 publications

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“…In another subset for a nested case-cohortbased study of the risk of lung cancer in the same cohort we found no association between fruit and vegetable intake and 8-oxodG excretion (33). Moreover, studies of a high intake or intervention with fruits and vegetables in particular with high diversity or supplements with putatively active compounds collectively suggest decreased DNA oxidation in leukocytes and 8-oxodG excretion (28,45,46). Nevertheless, neither smoking nor intake of fruit or vegetables seemed to modify the associations between 8-oxodG excretion and risk of breast cancer.…”

Section: Discussionmentioning

confidence: 67%

Association between 8-oxo-7,8-dihydro-2′-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case–Control Study

Loft

Olsen

Möller

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Section: Discussionmentioning

confidence: 67%

Association between 8-oxo-7,8-dihydro-2′-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case–Control Study

Loft

Olsen

Möller

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The simplest mechanism involves foods and nutrients with antioxidant properties, which work by intercepting free radicals and preventing cellular damage (38,39). To establish the potential chemopreventive properties of (39,40) have reviewed these intervention studies and concluded that most had extremely low statistical power (sample size usually V20), that the interventions led to modest changes in 8-hydroxy-2 ¶-deoxyguanosine (f10%), and that single doses of antioxidants seemed to be more effective than multiple doses, whereas the type of antioxidant was not crucial. Other research, not reviewed here, has used urinary metabolites of tobacco-specific carcinogens as intermediate biomarkers in chemoprevention studies [see Hecht et al (41) for example].…”

Section: The Use Of Biomarkers In Exposure Intervention Chemopreventmentioning

confidence: 99%

Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old

Víneis

Perera

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

161

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The purpose of this review is to evaluate progress in molecular epidemiology over the past 24 years in cancer etiology and prevention to draw lessons for future research incorporating the new generation of biomarkers. Molecular epidemiology was introduced in the study of cancer in the early 1980s, with the expectation that it would help overcome some major limitations of epidemiology and facilitate cancer prevention. The expectation was that biomarkers would improve exposure assessment, document early changes preceding disease, and identify subgroups in the population with greater susceptibility to cancer, thereby increasing the ability of epidemiologic studies to identify causes and elucidate mechanisms in carcinogenesis. The first generation of biomarkers has indeed contributed to our understanding of risk and susceptibility related largely to genotoxic carcinogens.Consequently, interventions and policy changes have been mounted to reduce risk from several important environmental carcinogens. Several new and promising biomarkers are now becoming available for epidemiologic studies, thanks to the development of highthroughput technologies and theoretical advances in biology. These include toxicogenomics, alterations in gene methylation and gene expression, proteomics, and metabonomics, which allow large-scale studies, including discovery-oriented as well as hypothesis-testing investigations. However, most of these newer biomarkers have not been adequately validated, and their role in the causal paradigm is not clear. There is a need for their systematic validation using principles and criteria established over the past several decades in molecular cancer epidemiology. (Cancer Epidemiol Biomarkers Prev 2007;16(10):1954 -65)

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“…Urinary excretion products of oxidized DNA are considered as measurements of whole-body exposure representing repaired DNA lesions, sanitation of the nucleotide pool, and apoptosis (9). The chromatographically measurement of 8-oxodG in urine is considered to be more specific than the antibody-based ELISA method where insufficient specificity of the antibodies is a problem (10,11). A discrepancy between these methods can be discerned in studies where the subjects have been exposed to high altitude hypoxia for more than 24 h; there is increased urinary excretion of 8-oxodG detected by the antibody-based methods (12)(13)(14), whereas the 2.02-fold, day 14:…”

Section: Specificity Of Biomarkersmentioning

confidence: 99%

Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models

et al. 2008

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SummaryThe objective of this review was to evaluate the association between hypoxia and oxidative damage to DNA and lipids. Evaluation criteria encompassed specificity and validation status of the biomarkers, study design, strength of the association, dose-response relationship, biological plausibility, analogous exposures, and effect modification by intervention. The collective interpretation indicates persuasive evidence from the studies in humans for an association between hypoxia and elevated levels of oxidative damage to DNA and lipids. The levels of oxidatively generated DNA lesions and lipid peroxidation products depend on both the duration and severity of the exposure to hypoxia. Largest effects are observed with exposure to hypoxia at high altitude, but other factors, including ultraviolet light, exercise, exertion, and low intake of antioxidants, might contribute to the effect observed in subjects at high altitude. Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity.2008 IUBMB IUBMB Life, 60(11): 707-723, 2008

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Dietary antioxidants and beneficial effect on oxidatively damaged DNA

Cited by 127 publications

References 188 publications

Association between 8-oxo-7,8-dihydro-2′-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case–Control Study

Association between 8-oxo-7,8-dihydro-2′-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case–Control Study

Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old

Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models

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