Dietary anthocyanins as potential natural modulators for the prevention and treatment of non-alcoholic fatty liver disease: A comprehensive review

Mehmood, Arshad; Zhao, Lei; Wang, Yong; Pan, Fei; Hao, Shuai; Zhang, Huimin; Iftikhar, Asra; Usman, Muhammad

doi:10.1016/j.foodres.2021.110180

Cited by 39 publications

(18 citation statements)

References 256 publications

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“…Anthocyanins are safe, non-toxic, and can be used in both food and medicine. Previous studies have shown that [19] anthocyanins improve lipid and glucose metabolism, and enhance antioxidant and anti-inflammatory activities and intestinal microecology. Furthermore, LRMderived anthocyanins possess remarkable oxidation resistance, as well as anti-inflammatory and anti-aging properties, is also used as colorants.…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin extract from Lycium ruthenicum enhanced production of biomass and polysaccharides during submerged fermentation of Agaricus bitorquis (Quél.) Sacc. Chaidam

Chen

et al. 2021

Bioprocess Biosyst Eng

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Agaricus bitorquis (Quél.) Sacc. Chaidam (ABSC) is a wild edible fungus uniquely found in the Tibet Plateau. ABSC is rich in polysaccharides that are considered biologically active. This study aimed to determine the feasibility of enhancing exopolysaccharide (EPS) production by ABSC in shake flask culture by supplementing the fermentation medium with anthocyanin extract. Different concentrations of Lycium ruthenicum Murr. (LRM) anthocyanin crude extract were tested on ABSC fermentation. The activity of phosphoglucose isomerase (PGI), phosphoglucose mutase (PGM), and phosphomannose isomerase (PMI), enzymes presumably involved in EPS synthesis by ABSC, was determined. ABSC transcriptomic profile in response to the presence of anthocyanins during fermentation was also investigated. LRM anthocyanin crude extract (0.06 mg/mL) was most effective in increasing EPS content and mycelial biomass (by 208.10% and 105.30%, respectively, P < 0.01). The activity of PGI, PGM, and PMI was increased in a medium where LRM anthocyanin extract and its main components (proanthocyanidins and petunia anthocyanin) were added. RNA-Seq analysis showed that 349 genes of ABSC were differentially expressed during fermentation in the medium containing anthocyanin extract of LRM; 93 genes were up-regulated and 256 genes down-regulated. From gene ontology enrichment analysis, differentially expressed genes were mostly assigned to carbohydrate metabolism and signal transduction categories. Collectively, LRM anthocyanins extract positively affected EPS production and mycelial biomass during ABSC fermentation. Our study provides a novel strategy for improving EPS production and mycelial growth during ABSC liquid submerged fermentation.

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Section: Introductionmentioning

confidence: 99%

Anthocyanin extract from Lycium ruthenicum enhanced production of biomass and polysaccharides during submerged fermentation of Agaricus bitorquis (Quél.) Sacc. Chaidam

Chen

et al. 2021

Bioprocess Biosyst Eng

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“…Meanwhile, diosgenin improved the disturbance of gut microbiota, which also exhibited significant correlations with lipid and amino acid metabolism. Concretely, diosgenin decreased abnormally elevated Globicatella, Phascolarctobacterium, Pseudochrobactrum, and uncultured_bacterium_f_ Prevotellaceae ( Newgard et al, 2009 ; Xu et al, 2014 ; Cheng et al, 2015 ; Romero-Gomez et al, 2017 ; Jin Zhang et al, 2020 ; Asnicar et al, 2021 ; Mehmood et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats

Zhou

Zheng

et al. 2022

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease closely associated with dietary habits. Diosgenin is abundant in yam, a common food and traditional Chinese medicine. The molecular mechanism of diosgenin on NAFLD has been preliminarily explored. However, the effect of diosgenin on metabolism and gut microbiota in NAFLD has not been reported. This study confirmed that diosgenin could suppress excessive weight gain, reduce serum levels of total cholesterol and triglycerides, and decrease liver fat accumulation in high-fat diet-induced NAFLD rats. Moreover, fecal metabolomics analysis suggested diosgenin improved abnormal lipid and amino acid metabolism. Bile acids, including lithocholic acid and ursodeoxycholic acid 3-sulfate that function as excretion, absorption, and transport of fats, were remarkably regulated by diosgenin. Aromatic amino acid and lysine metabolism was regulated by diosgenin as well. 16S rRNA gene sequencing analysis demonstrated that diosgenin restored gut microbiota disorder, especially Globicatella, Phascolarctobacterium, Pseudochrobactrum, and uncultured_bacterium_f_Prevotellaceae at the genus level. Additionally, these regulated bacterial genera showed significant correlations with lipid and amino acid metabolism-related biomarkers. This study further confirmed the significant effect of diosgenin on NAFLD, and provided a new perspective for the mechanism.

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“…The basic structural unit of anthocyanins is 2-phenylbenzopyran, which comprises a C6–C3–C6 backbone [ 49 ]. Its unique structure enables it to exert anti-oxidation, anti-inflammation, and antitumor functions [ 50 ], as well as those related to the prevention of cardiovascular disease and enhancement of vision [ 51 ]. In the present study, we found that the anthocyanin content of B .…”

Section: Discussionmentioning

confidence: 99%

Nutritional composition and antioxidant properties of the fruit of Berberis heteropoda Schrenk

Sun

et al. 2022

PLoS ONE

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Objective This study assessed the major nutrients and antioxidant properties of Berberis heteropoda Schrenk fruits collected from the Nanshan Mountain area of Urumqi City, Xinjiang Uygur Autonomous Region, China. Methods and materials We assessed the basic nutrients, including amino acids, minerals, and fatty acids, and determined the total phenol, flavonoid, and anthocyanin contents of the extracts. Results The analytical results revealed the average water (75.22 g/100 g), total fat (0.506 g/100 g), total protein (2.55 g/100 g), ash (1.31 g/100 g), and carbohydrate (17.72 g/100 g) contents in fresh B. heteropoda fruit, with total phenol, flavonoid, and anthocyanin contents of B. heteropoda fruits at 68.55 mg gallic acid equivalents/g, 108.42 mg quercetin equivalents/g, and 19.83 mg cyanidin-3-glucoside equivalent/g, respectively. Additionally, UPLC-Q-TOF-MSE analysis of polyphenols in B. heteropoda fruit revealed 32 compounds. Conclusion B. heteropoda fruits may have potential nutraceutical value and represent a potential source of nutrition and antioxidant phytochemicals in the human diet.

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Dietary anthocyanins as potential natural modulators for the prevention and treatment of non-alcoholic fatty liver disease: A comprehensive review

Cited by 39 publications

References 256 publications

Anthocyanin extract from Lycium ruthenicum enhanced production of biomass and polysaccharides during submerged fermentation of Agaricus bitorquis (Quél.) Sacc. Chaidam

Anthocyanin extract from Lycium ruthenicum enhanced production of biomass and polysaccharides during submerged fermentation of Agaricus bitorquis (Quél.) Sacc. Chaidam

Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats

Nutritional composition and antioxidant properties of the fruit of Berberis heteropoda Schrenk

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