Dietary Anthocyanins against Obesity and Inflammation

Abstract

Chronic low-grade inflammation plays a pivotal role in the pathogenesis of obesity, due to its associated chronic diseases such as type II diabetes, cardiovascular diseases, pulmonary diseases and cancer. Thus, targeting inflammation is an attractive strategy to counter the burden of obesity-induced health problems. Recently, food-derived bioactive compounds have been spotlighted as a regulator against various chronic diseases due to their low toxicity, as opposed to drugs that induce severe side effects. Here we describe the beneficial effects of dietary anthocyanins on obesity-induced metabolic disorders and inflammation. Red cabbage microgreen, blueberry, blackcurrant, mulberry, cherry, black elderberry, black soybean, chokeberry and jaboticaba peel contain a variety of anthocyanins including cyanidins, delphinidins, malvidins, pelargonidins, peonidins and petunidins, and have been reported to alter both metabolic markers and inflammatory markers in cells, animals, and humans. This review discusses the interplay between inflammation and obesity, and their subsequent regulation via the use of dietary anthocyanins, suggesting an alternative dietary strategy to ameliorate obesity and obesity associated chronic diseases.

Anthocyanins ameliorate palmitate‐induced inflammation and insulin resistance in 3T3‐L1 adipocytes

“…Conversely, ACN extract pretreatment reduces lipid accumulation by affecting the transcriptional factor PPARγ protein levels. These data are in accordance with in vivo studies reporting that the supplementation with ACNs prevented weight gain and modulated markers of obesity in high fat diet‐fed mice with a concomitant down‐regulation of PPARγ and SREBP1c (Y. M. Lee et al, ) and suppression of the mRNA levels of the fatty acid and triglyceride synthesis‐related genes (T. Wu, Jiang, Yin, Long, & Zheng, ).…”

Cyanidin and cyanidin-3-glucoside derived from Vigna unguiculata act as noncompetitive inhibitors of pancreatic lipase

“…The importance of plant polyphenols in human diet and natural medicine has been studied extensively. Epidemiological studies evidence that a polyphenol‐rich diet protects against the development of chronic diseases, particularly diabetes and cardiovascular diseases (Lee et al, ; Williamson, ). Polyphenolic compounds have been shown to inhibit digestive enzymes involved in starch and lipid digestion, such as α‐amylase, α‐glucosidase, and pancreatic lipase (Buchholz & Melzig, ; Sosnowskaa, Podsędeka, Redzyniaa, & Kucharskab, ).…”

“…In the present study, we examined the TPC in various legumes, and the maximum level was observed with Vigna unguiculata. Wedick et al (2012) and others demonstrated that, among flavonoids, the consumption of anthocyanins could be significantly associated with health-promoting properties against chronic diseases (Khoo, Azlan, Tang, & Lim, 2017;Lee et al, 2017;Wedick et al, 2012). Mostly, legumes are consumed with the coat even after cooking, and there was no significant change in the biological activity after cooking or thermal processing (Ombra et al, 2016).…”

“…diabetes and cardiovascular diseases(Lee et al, 2017; Williamson, 2017). Polyphenolic compounds have been shown to inhibit digestive enzymes involved in starch and lipid digestion, such as α-amylase, α-glucosidase, and pancreatic lipase(Buchholz & Melzig, 2015;Sosnowskaa, Podsędeka, Redzyniaa, & Kucharskab, 2018).…”

Nutraceutical and Medicinal Property of Mulberry Fruits: A Review on Its Pharmacological Potential

“…As discussed earlier, mulberry fruit is enriched with the different bioactive components, which has a therapeutic effect on human health (50,51). Out of these bioactive components, anthocyanins of mulberry fruits can restrain low density lipoprotein (LDL) oxidation and scavenge the free radicals(52,53).…”