Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats

Herrera-Meza, M S; Mendoza-López, Ma. Remedios; García-Barradas, Óscar; Sánchez-Otero, María G.; Silva-Hernandez, E. R.; Angulo, Joaquín; Oliart-Ros, Rosa María

doi:10.3109/09637486.2013.763908

Cited by 22 publications

(29 citation statements)

References 89 publications

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“…[28] However, clinical trials suggest the opposite and indicate cis-VA as a protective factor toward cardiovascular diseases [29] (Table 2). Similarly, animal studies with spontaneously hypertensive rats [34] and LDLr( −/− ) mice [35] showed the beneficial effects of cis-VA in lowering blood pressure and lowering blood cholesterol levels.…”

Section: Palmitoleic Acid Elongation Product In Metabolic Diseasementioning

confidence: 85%

“…Animal studies [30] Lean (2:1 mix of +/cp and +/+) and obese (cp/cp) JCR:LA-cp rats, fed 3-week a control diet (0% VA) or a VA diet (1.5% w/w) VA was ↑ in plasma phospholipids versus control-fed rats Lean VA-fed rats: ↓ proportions of CD45RC+ helper cells, and T-helper cells ↓ IL-2, IL-10, and TNF-α in spleen Obese VA-fed rats: normalized IL-2 and TNF-α in MLN to those seen in lean rats [35] LDLr −/− mice fed 14-week with atherogenic diet (2% cholesterol) (CH) or 15% vaccenic butter (1.5% w/w VA) (VB) CH + VB: ↓ serum cholesterol and triglyceride levels, ↓ atherosclerosis [34] Spontaneously hypertensive rats fed 7-week with AMF (rich in VA and CLA), or AMF + sterculic oil (SO; which inhibits the conversion of VA into CLA)…”

Section: Reference Experimental or Clinical Model Major Findingsmentioning

confidence: 99%

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Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Souza

Vannice²,

Neto

et al. 2017

Molecular Nutrition Food Res

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Although dietary fatty acids can modulate metabolic and immune responses, the effects of palmitoleic acid (16:1n-7) remain unclear. Since this monounsaturated fatty acid is described as a lipokine, studies with cell culture and rodent models have suggested it enhances whole body insulin sensitivity, stimulates insulin secretion by β cells, increases hepatic fatty acid oxidation, improves the blood lipid profile, and alters macrophage differentiation. However, human studies report elevated blood levels of palmitoleic acid in people with obesity and metabolic syndrome. These findings might be reflection of the level or activity of stearoyl-CoA desaturase-1, which synthesizes palmitoleate and is enhanced in liver and adipose tissue of obese patients. The aim of this review is to describe the immune-metabolic effects of palmitoleic acid observed in cell culture, animal models, and humans to answer the question of whether palmitoleic acid is a plausible nonpharmacological strategy to prevent, control, or ameliorate chronic metabolic and inflammatory disorders. Despite the beneficial effects observed in cell culture and in animal studies, there are insufficient human intervention studies to fully understand the physiological effects of palmitoleic acid. Therefore, more human-based research is needed to identify whether palmitoleic acid meets the promising therapeutic potential suggested by the preclinical research.

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Section: Palmitoleic Acid Elongation Product In Metabolic Diseasementioning

confidence: 85%

Section: Reference Experimental or Clinical Model Major Findingsmentioning

confidence: 99%

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Souza

Vannice²,

Neto

et al. 2017

Molecular Nutrition Food Res

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“…In a cohort of 1373 Finnish men, cis-vaccenic acid in erythrocyte membranes was associated with higher concentrations of adiponectin [46]. Moreover, administration of dietary anhydrous milk fat naturally enriched with CLA and trans-vaccenic acid for 7 weeks increased plasma adiponectin in spontaneous hypertensive rats [47]. Plasma adiponectin levels can also be increased by thiazolidinediones which are a class of medications used in the treatment of T2D to increase glucose uptake without increasing insulin secretion [44].…”

Section: Discussionmentioning

confidence: 98%

Natural Rumen‐Derived trans Fatty Acids Are Associated with Metabolic Markers of Cardiac Health

Silva

Julien²,

Pérusse

et al. 2015

Lipids

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Evidence suggests that industrial trans fatty acids (iTFA) impair lipid profiles while ruminant trans fatty acids (rTFA) may lower insulin resistance and blood pressure. The objective of this article was to determine if the plasma phospholipid percentage of rTFA is associated with a favorable cardiometabolic profile. We collected fasting blood samples from 200 individuals from Quebec city (QC, Canada) aged from 18 to 55 years old, including 100 obese (BMI ≥ 30 kg m(-2)) and 100 non-obese (BMI < 30 kg m(-2)) men and women. Fatty acid levels in plasma phospholipids were determined using gas chromatography. After separating the subjects into two groups, according to the median percentage of rTFA in plasma phospholipids, participants in the group with higher percentages of rTFA (0.86 ± 0.24 %) had higher adiponectin levels (p = 0.01) and a lower blood pressure (systolic, p = 0.005; diastolic, p = 0.04). In contrast, concentrations in plasma phospholipids of elaidic acid, a major iTFA, are positively correlated with glycemia in non-obese subjects (p = 0.01) and with both triacylglycerol (TAG) (p = 0.0007) and total cholesterol (TC) (p = 0.009) in obese subjects. These data suggest that rTFA may have beneficial effects on cardiometabolic risk factors conversely to their counterpart iTFA. Dietary sources of TFA should be taken into account in future cardiometabolic studies.

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“…We have found that the administration of natural seed oil from S. mexicana to spontaneously hypertensive rats provokes an inhibition of SCD activity (Herrera-Meza et al, 2013). Whether these modifications may cause a loss in the inhibitory activity of sterculic oil over SCD remains to be investigated.…”

Section: Figure 2 Total Ion Current Gas Chromatograms Of the Fatty Amentioning

confidence: 97%

“…Results on fatty acid composition were compared to those previously found for S. mexicana (Herrera-Meza et al, 2013). Seeds from S. mexicana were collected from six trees found in Las Choapas (17° 15′ N, 99° 15′ W, altitude 115 m) in February and March.…”

Section: Sample Collectionmentioning

confidence: 99%

Fatty acid composition and some physicochemical characteristics of <em>Sterculia apetala</em> seed oils

Herrera‐Meza¹,

Martínez²,

Sánchez-Otero³

et al. 2014

Grasas y Aceites

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SUMMARY:In the tropical rain forests of southeastern Mexico, the use of Sterculia mexicana and Sterculia apetala seed oils for human and animal nutrition is common. However, the seeds contain cyclopropene fatty acids, whose consumption is related with beneficial as well as detrimental physiological effects. The aim of this study was to determine the fatty acid profile and the physicochemical characteristics of S. apetala seed oil and to evaluate the effect of roasting on both aspects. Cyclopropenoic fatty acids, sterculic acid and malvalic acid were identified in the natural and roasted seed oils. The major component in the seed oil was sterculic acid, as has been reported for Sterculia mexicana and Sterculia foetida. The roasting process modified some physicochemical properties and the fatty acid composition of the seed oil, particularly by decreasing its content of sterculic acid. To our knowledge, this is the first report on the fatty acid composition of S. apetala seed oil. KEYWORDS: Cyclopropenoic Fatty Acids; Sterculia apetala; Sterculia mexicana; Sterculic acidRESUMEN: Determinación de la composición de ácidos grasos y algunas características fisicoquímicas del aceite de semillas de Sterculia apetala. En zonas tropicales del sureste de México, el uso de semillas de Sterculia mexicana y Sterculia apetala es común para consumo humano y animal. Sin embargo, dichas semillas contienen ácidos grasos ciclopropenoicos, los cuales se les ha relacionado tanto con efectos fisiológicos beneficiosos como adversos para la salud. El objetivo de este estudio fue determinar el perfil de ácidos grasos y las características fisicoquímicas de la especie S. apetala, así como la evaluación del aceite sometido a un proceso de tostado. Se identificaron ácidos grasos ciclopropenoicos como el ácido estercúlico y malválico, en el aceite natural y tostado. Para las especies S. mexicana y S. foetida, el componente mayoritario en las semillas fue el ácido estercúlico. El proceso de tostado modificó algunas propiedades fisicoquímicas y la composción de los ácidos grasos, especificamente disminuyó el contenido de ácido estercúlico. Para nuestro conocimiento, este es la primera información publicada sobre la composición de los ácidos grasos de la especie S. apetala.

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Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats

Cited by 22 publications

References 89 publications

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?

Natural Rumen‐Derived trans Fatty Acids Are Associated with Metabolic Markers of Cardiac Health

Fatty acid composition and some physicochemical characteristics of <em>Sterculia apetala</em> seed oils

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