Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

Huang, Xuemin; Liu, Yanhua; Zhang, Han; Cao, Yuan; Dou, Weifeng; Duan, Dandan; Chen, Huanan; Bo, Yacong; Amoah, Adwoa Nyantakyiwaa; Fu, Wenjun; Zhao, Xin; Zeng, Fangfang; Chen, Yuming; Lyu, Quanjun

doi:10.1017/s0007114521002956

Cited by 7 publications

(12 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to antioxidant nutrients, vitamin D supplementation has been proposed for the prevention of PE, although evidence has been inconsistent [ 56 ]. Our previous research observed a negative relationship between dietary VD intake and PE risk [ 57 ]. Vitamin D is a regulator of inflammation and may affect the occurrence of PE by regulating maternal immune response and reducing the concentrations of proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case–control study

Kang

Liu

Chen

et al. 2022

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

Background The effect of carotenoids on the risk of preeclampsia (PE) is uncertain. We aimed to examine the associations between the intake of dietary carotenoids and related compounds by pregnant women in China, and the risk of their developing PE. Methods Four hundred and forty PE cases and 440 age- (± 3 years), gestational age- (± 1 weeks) and gestational diabetes mellitus status- (yes/no) matched healthy controls were recruited from March 2016 to June 2019. Dietary intake of carotenoids was assessed using a 79-item validated food-frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Results After adjusting for potential confounders, we found that the intake of total carotenoids, β-carotene, β-cryptoxanthin, lycopene, and lutein and zeaxanthin (lut-zea) were negatively associated with the odds of developing PE. Compared with the lowest quartile intake, the multivariate-adjusted OR (95% CI) of the highest quartile intake was 0.29 (0.16–0.54, Ptrend < 0.001) for total carotenoids, 0.31 (0.16–0.58, Ptrend < 0.001) for β-carotene, 0.50 (0.27–0.90, Ptrend = 0.007) for β-cryptoxanthin, 0.55 (0.30–0.99, Ptrend = 0.04) for lycopene and 0.32 (0.17–0.61, Ptrend = 0.001) for lut-zea. However, no significant associations were observed between the risk of developing PE and α-carotene intake (OR = 0.75, 95% CI: 0.41–1.36, Ptrend = 0.28). Moreover, similar negative associations were found for every one-standard-deviation increase in the intake of total carotenoids, β-carotene, β-cryptoxanthin, lycopene and lut-zea. Conclusion These results indicate that a high intake of total carotenoids, β-carotene, β-cryptoxanthin, lycopene and lut-zea may be associated with a low risk of developing PE.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case–control study

Kang

Liu

Chen

et al. 2022

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

show abstract

“…The sample size of this 1:1-matched case–control study was calculated based on the OR estimated from previous studies (OR = 0.45) ( 29 ). A sample size of 134 was calculated based on the aforementioned assumptions.…”

Section: Methodsmentioning

confidence: 99%

Dietary intake and serum concentrations of vitamin A and vitamin E and pre-eclampsia risk in Chinese pregnant women: A matched case-control study

Liu

Huang

et al. 2023

Front. Nutr.

Self Cite

View full text Add to dashboard Cite

BackgroundMany studies have suggested that the serum concentrations of vitamin A (VA) and vitamin E (VE) influence preeclampsia (PE) risk in pregnant women. However, few studies have assessed whether dietary intake and serum concentrations of VA and VE are correlated with PE risk.MethodsA 1:1 matched case-control study was conducted to explore the association between the dietary intake and serum concentrations of VA and VE and the risk of PE in pregnant Chinese women. A total of 440 pregnant women with PE and 440 control pregnant women were included in the study. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of VA and VE were measured by liquid chromatography-tandem mass spectrometry.ResultsCompared with the lowest quartile, the multivariate-adjusted odds ratios [95% confidence interval (CI)] of the highest quartiles were 0.62 (95% CI: 0.40-0.96, P trend = 0.02) for VA, 0.51 (95% CI: 0.33–0.80, P trend =0.002) for β-carotene, and 0.70 (95% CI: 0.45–1.08, P trend = 0.029) for retinol. Additionally, for serum VA and VE concentrations, the multivariate-adjusted odds ratios (95% CI) were 2.75 (95% CI: 1.24–6.13, P trend = 0.002) and 11.97 (95% CI: 4.01–35.77, P trend < 0.001), respectively. No significant association was seen between VE intake and PE risk.ConclusionsDietary VA intake was negatively correlated with PE risk, and serum VA and VE concentrations were positively correlated with PE risk among pregnant Chinese women.

show abstract

“…This study was performed between March 2016 and June 2019 at the First Affiliated Hospital of Zhengzhou University, China. Full details about the study design have been published in previous studies (21)(22)(23) . In particular, a total of 466 cases with a ratio of 1:1 matched for case control were enrolled.…”

Section: Study Population and Study Designmentioning

confidence: 99%

Dietary inflammatory index, inflammation biomarkers and preeclampsia risk: a hospital-based case–control study

et al. 2022

View full text Add to dashboard Cite

This study evaluated the association between inflammatory diets as measured by the dietary inflammatory index (DII), and inflammation biomarkers, and the development of preeclampsia among the Chinese population. We followed the reporting guidelines of the STROBE statement for observational studies. A total of 466 preeclampsia cases aged over 18 years were recruited between March 2016 and June 2019, and 466 healthy controls were 1:1 ratio matched by age (± 3 years), week of gestation (± 1 week), and gestational diabetes mellitus. The energy-adjusted DII (E-DII) was computed based on dietary intake assessed using a 79-item semiquantitative food frequency questionnaire (FFQ). Inflammatory biomarkers were analyzed by ELISA kits. The mean E-DII scores were -0.65 ± 1.58 for cases and -1.19 ± 1.47 for controls (P value <0.001). E-DII scores positively correlated with IFN-γ (r s = 0.194, P value = 0.001) and IL-4 (r s = 0.135, P value = 0.021). After multivariable adjustment, E-DII scores were positively related to preeclampsia risk (P trend <0.001). The highest tertile of E-DII was 2.18 times the lowest tertiles (95% CI = 1.52, 3.13). The odds of preeclampsia increased by 30% (95% CI= 18%, 43%, P value <0.001) for each E-DII score increase. The preeclampsia risk was positively associated with IL-2 (OR = 1.07, 95% CI = 1.03, 1.11), IL-4 (OR = 1.26, 95% CI = 1.03, 1.54) and TGF-β (OR = 1.17, 95% CI = 1.06, 1.29). Therefore, proinflammatory diets, corresponding to higher IL-2, IL-4 and TGF-β levels, were associated with increased preeclampsia risk.

show abstract

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

Cited by 7 publications

References 49 publications

Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case–control study

Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case–control study

Dietary intake and serum concentrations of vitamin A and vitamin E and pre-eclampsia risk in Chinese pregnant women: A matched case-control study

Dietary inflammatory index, inflammation biomarkers and preeclampsia risk: a hospital-based case–control study

Contact Info

Product

Resources

About