Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood

Lee-Sarwar, Kathleen; Kelly, Rachel S.; Lasky‐Su, Jessica; Kachroo, Priyadarshini; Zeiger, Robert S.; O’Connor, George T.; Sandel, Megan; Bacharier, Leonard B.; Beigelman, Avraham; Laranjo, Nancy; Gold, Diane R.; Weiss, Scott T.; Litonjua, Augusto A.

doi:10.1016/j.jaip.2018.07.039

Cited by 45 publications

(55 citation statements)

References 55 publications

(139 reference statements)

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“…27 Indeed, dietary and circulating PUFAs have been associated with asthma, including in the VDAART cohort. 24 However, we found no association between plasma PUFAs and intestinal PUFAs in the present analysis. Although members of the human intestinal microbiota are not known to produce PUFAs, some participate in metabolism of PUFAs.…”

Section: Discussioncontrasting

confidence: 80%

“…Recently, we found that plasma PUFAs were inversely associated with asthma at age 3 years in VDAART participants. 24 Given the present findings of inverse associations between intestinal PUFAs and other lipid metabolite modules and asthma, we hypothesized that plasma and intestinal lipids can be correlated. However, we found no correlation between plasma PUFAs (total, omega-3 or omega-6), endocannabinoids, or diacylglycerols and their corresponding intestinal metabolite module eigenvalues (see Table E6 in this article's Online Repository at www.jacionline.org).…”

Section: Intestinal and Plasma Metabolomes Associate With Childhood Amentioning

confidence: 94%

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Integrative analysis of the intestinal metabolome of childhood asthma

Lee-Sarwar

Kelly

Lasky‐Su

et al. 2019

Journal of Allergy and Clinical Immunology

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Pharmaceuticals to Boston University that funds a study of the pathogenesis of chronic obstructive pulmonary disease. L. B. Bacherier participates in the Data Safety Monitoring Board of DBV Technologies. A. Beigelman holds stock from DBV Technologies. A. A. Litonjua has received author royalties from UpToDate and consultant fees from AstraZeneca. The rest of the authors declare that they have no relevant conflicts of interest. Trial registration: ClinicalTrials.gov NCT00920621.

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Section: Discussioncontrasting

confidence: 80%

Section: Intestinal and Plasma Metabolomes Associate With Childhood Amentioning

confidence: 94%

Integrative analysis of the intestinal metabolome of childhood asthma

Lee-Sarwar

Kelly

Lasky‐Su

et al. 2019

Journal of Allergy and Clinical Immunology

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“…The presence of caffeine was associated with lower odds of asthma at 3 years of age. Her group found that high concentrations of polyunsaturated fatty acid (PUFA) and Vitamin D were associated with a large reduction in asthma risk (52). They also identified a potential role in asthma of the sphingolipid biosynthesis regulator ORMDL3.…”

Section: Systems Biologymentioning

confidence: 99%

Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference

et al. 2020

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Other than clean drinking water, vaccines have been the most effective public health intervention in human history, yet their full potential is still untapped. To date, vaccine development has been largely limited to empirical approaches focused on infectious diseases and has targeted entire populations, potentially disregarding distinct immunity in vulnerable populations such as infants, elders, and the immunocompromised. Over the past few decades innovations in genetic engineering, adjuvant discovery, formulation science, and systems biology have fueled rapid advances in vaccine research poised to consider demographic factors (e.g., age, sex, genetics, and epigenetics) in vaccine discovery and development. Current efforts are focused on leveraging novel approaches to vaccine discovery and development to optimize vaccinal antigen and, as needed, adjuvant systems to enhance vaccine immunogenicity while maintaining safety. These approaches are ushering in an era of precision vaccinology aimed at tailoring immunization for vulnerable populations with distinct immunity. To foster collaboration among leading vaccinologists, government, policy makers, industry partners, and funders from around the world, the Precision Vaccines Program at Boston Children's Hospital hosted the 2 nd International Precision Vaccines Conference (IPVC) at Harvard Medical School on the 17 th-18 th October 2019. The conference convened experts in vaccinology, including vaccine formulation and adjuvantation, immunology, cell signaling, systems biology, biostatistics, bioinformatics, as well as vaccines for non-infectious indications such as cancer and opioid use disorder. Herein we review highlights from the 2 nd IPVC and discuss key concepts in the field of precision vaccines.

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“…It was shown in mice that deficiency of dietary fiber intake increases the susceptibility to OVA induced allergic airway inflammation (121). Additionally, it was shown that uptake of polyunsaturated fatty acids can increase the production of SCFA's by bacteria (122) and the dietary intake of poly unsaturated fatty acids was inversely associated with atopy in childhood (123).…”

Section: Oral Tolerancementioning

confidence: 99%

Regulatory Immune Mechanisms in Tolerance to Food Allergy

et al. 2018

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Oral tolerance can develop after frequent exposure to food allergens. Upon ingestion, food is digested into small protein fragments in the gastrointestinal tract. Small food particles are later absorbed into the human body. Interestingly, some of these ingested food proteins can cause allergic immune responses, which can lead to food allergy. So far it has not been completely elucidated how these proteins become immunogenic and cause food allergies. In contrast, oral tolerance helps to prevent the pathologic reactions against different types of food antigens from animal or plant origin. Tolerance to food is mainly acquired by dendritic cells, epithelial cells in the gut, and the gut microbiome. A subset of CD103+ DCs is capable of inducing T regulatory cells (Treg cells) that express anti-inflammatory cytokines. Anergic T cells also contribute to oral tolerance, by reducing the number of effector cells. Similar to Treg cells, B regulatory cells (Breg cells) suppress effector T cells and contribute to the immune tolerance to food allergens. Furthermore, the human microbiome is an essential mediator in the induction of oral tolerance or food allergy. In this review, we outline the current understanding of regulatory immune mechanisms in oral tolerance. The biological changes reflecting early consequences of immune stimulation with food allergens should provide useful information for the development of novel therapeutic treatments.

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Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood

Abstract: PUFA dietary intake and plasma levels are inversely associated with asthma and/or recurrent wheeze and atopy at age 3 years. Antenatal vitamin D could modulate the effect of early childhood PUFA on risk of asthma and allergy.

Cited by 45 publications

References 55 publications

Integrative analysis of the intestinal metabolome of childhood asthma

Integrative analysis of the intestinal metabolome of childhood asthma

Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference

Regulatory Immune Mechanisms in Tolerance to Food Allergy

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