Dietary amino acids and the risk of hypertension in a Dutch older population: the Rotterdam Study

Kuil, Wieke Altorf-van der; Engberink, M.F.; Neve, Myriam De; Rooij, Frank J.A. van; Hofman, Albert; Veer, Pieter van’t; Witteman, Jacqueline C. M.; Franco, Oscar H.; Geleijnse, Johanna M.

doi:10.3945/ajcn.112.038737

Cited by 48 publications

(50 citation statements)

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“…In accordance with the present results, the Rotterdam study also showed no association between incident hypertension and several amino acids, such as arginine, lysine, glutamic acid, cysteine, and tyrosine. 34 In addition, serine and glycine were not considered by the Rotterdam study. 34 Although a large number of lipids of different classes were measured in this study, only 4 phosphatidylcholines metabolites (acyl-alkyl-phosphatidylcholines C42:4, C44:3, diacylphosphatidylcholines C38:3, and diacyl-phosphatidylcholines C38:4) were identified to be predictive to a certain extend for incident hypertension during the 10 years of follow-up time.…”

Section: Discussionmentioning

confidence: 99%

“…34 In addition, serine and glycine were not considered by the Rotterdam study. 34 Although a large number of lipids of different classes were measured in this study, only 4 phosphatidylcholines metabolites (acyl-alkyl-phosphatidylcholines C42:4, C44:3, diacylphosphatidylcholines C38:3, and diacyl-phosphatidylcholines C38:4) were identified to be predictive to a certain extend for incident hypertension during the 10 years of follow-up time. The partial plots suggest a protective role of the 2 acyl-alkylphosphatidylcholines C42:4 and C44:3 with increasing concentrations while only a certain concentration range of the diacyl-phosphatidylcholines C38:4 was protective regarding incident hypertension.…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Identification of Serum Metabolites Associated With Incident Hypertension in the European Prospective Investigation Into Cancer and Nutrition–Potsdam Study

et al. 2016

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Essential hypertension is among the most important preclinical conditions of metabolic syndrome and affects nearly 1 billion people worldwide.1,2 The risk to develop essential hypertension seems to be a function of age, triggered by an unhealthy lifestyle with obesity, and physical inactivity as major risk factors.1 Furthermore, dyslipidemia, 3 inflammatory processes, 4 and oxidative stress 5 have been closely linked to this preclinical condition. Although many pathophysiological mechanisms of hypertension have been elucidated, knowledge is scarce about individual metabolic alterations promoting the development of essential hypertension in healthy subjects or subjects in early stages of this condition.Application of metabolomics can contribute to fill this gap and generate further insights into the pathogenesis of hypertension development. Metabolites represent intermediates and end products of cellular processes and are substantial for signaling, structuring of membranes, and catalytic activity. Metabolic alterations associated with development of hypertension, therefore, may be present years before hypertension diagnosis. Hence, investigating metabolic profiles in prospective cohorts is a promising opportunity to improve our knowledge of incident hypertension and to discover novel biomarkers that elucidate early changes in potential pathways.In the US cohort, of 204 metabolites, the metabolite 4-hydroxyhippurate and a metabolic sex steroids pattern were associated with incident hypertension. 6 Another US study using metabolic profiling revealed an association of diacylglycerols, in general, and of the 2 diacylglycerols 16:0/22:5 and 16:0/22:6, in particular, with blood pressure (BP) and incident hypertension. 7 However, to our knowledge, only a few prospective studies have used metabolic profiling to investigate metabolic alterations associated with incident hypertension, 6,7 and thus further studies are necessary to elucidate this promising approach.This study aimed to identify metabolites associated with incident hypertension using data of 127 serum metabolites (Biocrates AbsoluteIDQ p150) determined within the European Prospective Abstract-Metabolomics is a promising tool to gain new insights into early metabolic alterations preceding the development of hypertension in humans. We therefore aimed to identify metabolites associated with incident hypertension using measured data of serum metabolites of the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam study. Targeted metabolic profiling was conducted on serum blood samples of a randomly drawn EPIC-Potsdam subcohort consisting of 135 cases and 981 noncases of incident hypertension, all of them being free of hypertension and not on antihypertensive therapy at the time of blood sampling. Mean follow-up was 9.9 years. A validated set of 127 metabolites was statistically analyzed with a random survival forest backward selection algorithm to identify predictive metabolites of incident hypertension taking into account important epidemiol...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Identification of Serum Metabolites Associated With Incident Hypertension in the European Prospective Investigation Into Cancer and Nutrition–Potsdam Study

et al. 2016

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“…The Rotterdam Study suggested no major role for cysteine, glutamic acid, arginine, lysine or tyrosine intake in determining blood pressure in a cross-sectional analysis. 20 There was also no association between intake of the 5 amino acids and risk of developing hypertension during 6 years of follow-up. 20 Mean cysteine intake was much higher in the Rotterdam Study (≈600 mg cysteine per 1000 kcal) than in our study (≈360 mg cysteine per 1000 kcal).…”

Section: Discussionmentioning

confidence: 94%

Dietary Cysteine and Other Amino Acids and Stroke Incidence in Women

Larsson

Håkansson

Wolk

2015

Stroke

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Evidence from animal studies, randomized trials, and observational studies indicates that dietary protein intake is inversely associated with blood pressure 1-3 and the risk of stroke. 4,5 A recent meta-analysis of 7 prospective studies found that intake of total and animal protein, but not vegetable protein, was significantly inversely associated with stroke risk. 4 Proteins in the diet are composed of several amino acids, each with different chemical properties. Cysteine is a nonessential sulfur-containing amino acid that may, at least in part, be responsible for the potential blood pressure and strokereducing effects of a high-protein diet. It is more abundant in animal and cereal proteins than in legume proteins. 6 Foods rich in cysteine include poultry, egg, beef, and whole grains. Cysteine may exert its antihypertensive effects directly or via its storage form, glutathione, by reducing oxidative stress and advanced glycation end products, improving insulin sensitivity and glucose metabolism, and modulating nitric oxide levels. 7 To the best of our knowledge, no study has examined the association between cysteine intake and risk of stroke.In a previous study, based on data from the Swedish Mammography Cohort (SMC), we observed inverse associations of total and animal protein intakes with stroke incidence. 8In this study, we evaluated the a priori hypothesis that cysteine intake is inversely associated with risk of stroke, and that cysteine may have contributed to our previous observed finding for dietary protein. We also provide results for other amino acids, most of which are highly correlated with protein intake, in relation to stroke risk. Methods Study PopulationThis study was based on data from the SMC, which is a populationbased prospective cohort study of Swedish women. 9 In the autumn of 1997, 56 030 participants of the SMC obtained a comprehensive questionnaire that included ≈350 items on diet, other lifestyle factors, etc; 39 227 women (70%) returned a completed questionnaire. We excluded women with an erroneous or a missing personal identification number (n=243), women who did before start of follow-up (January 1, 1998; n=26), women with a diagnosis of cardiovascular disease (n=2492) or cancer (n=1811) before start of follow-up, and women with an implausibly high or low energy intake (ie, 3 SDs from the log e -transformed mean energy intake; n=405). After exclusions, 34 250 women aged 49−83 years remained for analysis. The study was approved by the Regional Ethical Review Board at the Karolinska Institutet in Stockholm.Background and Purpose-Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence. Methods-We used data from the Swedish Mammography Cohort, a population-based prospective cohort of 34 250 women who were free of cardiovascular disease and cancer and had completed a food-frequency questionnaire about diet and other risk factors for stro...

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“…The intake of glutamic acid, arginine, lysine, tyrosine and cysteine from food plays an important role in hypertension [17]. Among dietary factors, carbohydrates, sodium are risk factors for hypertension, and animal protein, riboflavin, niacin, calcium, phosphorus, zinc, magnesium, potassium, animal iron [18], potassium [19] are protective factors for hypertension.…”

Section: Discussionmentioning

confidence: 99%

Study on Chronic Diseases Comprehensive Intervention in Baoji of Shaanxi Province in China

Wang¹,

Deng²,

Qu³

et al. 2014

OJEpi

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Background: There is very limited data available about the epidemiology trial on chronic diseases comprehensive intervention. The aim of this study was to assess the effect of comprehensive intervention on chronic diseases in Baoji and provide basis for the improvement of chronic diseases intervention measures. Methods: Using four stages stratified random sampling method, comprehensive intervention measures were implemented on intervention group (575 individuals) respectively aimed at three crowds of whole population, high risk population and chronic diseases patients. The control group (782 individuals) did not receive special treatment. Two groups were evaluated effect after one year observation. Results: The chronic diseases prevalence rate of whole population in intervention group was lower than that in control group (P < 0.05), the blood pressure level and smoking proportion of high risk population in intervention group were lower than in control group (P < 0.05), and the blood pressure, blood glucose control rate of chronic diseases patients in intervention group were higher than in control group (P < 0.05). Conclusion: Comprehensive intervention could prevent the rise of chronic diseases prevalence. The intervention is effective in reducing or halting risk factors of high risk population, particularly in controlling blood pressure, blood glucose of patients. We should establish government leading, department cooperation, social participation, longtime and classified comprehensive intervention mechanism of chronic diseases. We believe that whole population should control the risk factors, high risk population should early diagnosis and treatment, chronic diseases patients should normalized management, and it could be applied in other counties.

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Dietary amino acids and the risk of hypertension in a Dutch older population: the Rotterdam Study

Abstract: Our data do not suggest a major role for glutamic acid, arginine, lysine, tyrosine, or cysteine intake (as % of protein intake) in determining population BP or risk of hypertension.

Cited by 48 publications

References 25 publications

Identification of Serum Metabolites Associated With Incident Hypertension in the European Prospective Investigation Into Cancer and Nutrition–Potsdam Study

Identification of Serum Metabolites Associated With Incident Hypertension in the European Prospective Investigation Into Cancer and Nutrition–Potsdam Study

Dietary Cysteine and Other Amino Acids and Stroke Incidence in Women

Study on Chronic Diseases Comprehensive Intervention in Baoji of Shaanxi Province in China

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