Dietary Amino Acids and Immune Response in Rats

Kenney, Mary Alice; Magee, Joan Linder; Piedad-Pascual, Felicitas

doi:10.1093/jn/100.9.1063

Cited by 24 publications

(13 citation statements)

References 21 publications

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“…Similar results were reported by Kenney et al (1970) in rats immunized with sheep red blood cells (SRBC). However, Gill and Gershoff (1967), working with Cebus albifron monkeys, reported no difference between control animals and those fed a methionine-deficient diet in either the primary or secondary responses to a synthetic polypeptide antigen.…”

Section: Introductionsupporting

confidence: 86%

Enhanced Immune Responses in Broiler Chicks Fed Methionine-Supplemented Diets

et al. 1987

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Effects of feeding supplementary methionine and choline on broiler growth and immunity were examined by supplementing a corn-soybean diet that contained 21% crude protein, 3,255 kcal metabolizable energy/kg diet, .35% methionine, .37% cystine, and .13% choline. Methionine (.063, .125, .25%) and choline (.125, .25%) were dietary variables. Sulfate (.055%) was added either alone or along with methionine (.125 or .25%) and choline (.125%). In one study, the .25% methionine diet was supplemented with .121% betaine. Sodium and chloride levels were constant in all the diets. Feed and distilled water were supplied ad libitum. Total antibodies, immunoglobulin (Ig) G (2-mercaptoethanol-resistant antibodies) and IgM (2-mercaptoethanol-sensitive antibodies) were determined in 3-wk-old chicks inoculated intraperitoneally with sheep red blood cells. The thymus-derived (T)-cell-dependent in vivo mitogen response to phytohemagglutinin-P (PHA-P) was assessed via wing web swelling. The methionine requirement for growth (0 to 3 wk of age) was approximately .413% of the diet (.35% in the basal diet plus .063% added). Supplementation of the basal diet with .125% choline stimulated growth to the same extent as did the extra .063% of methionine. Addition of .055% sulfate with .125% choline did not improve the ability of the latter to spare methionine. Supplemental methionine resulted in significant (P less than .05) dose-related increases in total antibody, IgG, and response to the mitogen PHA-P, but not in IgM. There were no effects of choline on the immune variables studied. These results suggest that methionine is required for select components of the antibody response, which effect might be related to T-cell help.

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Section: Introductionsupporting

confidence: 86%

Enhanced Immune Responses in Broiler Chicks Fed Methionine-Supplemented Diets

et al. 1987

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“…Reduced IgM production during Trp deficiency has also been observed in previous studies. 9 Given that IgG is the sole immune protein that can be transported across the fetal membrane, this further indicates the significance of Trp-promoted IgG production in protecting embryos from invading pathogens.…”

Section: Discussionmentioning

confidence: 98%

“…7 One possible explanation is that Trp is important in maintaining the circulating concentrations of immunoglobulins (Igs) such as IgM. 8,9 Further studies have revealed that the catabolites of Trp produced by indoleamine 2,3-dioxygenase (IDO), a key enzyme for degrading Trp outside the liver, can act directly on maternal immune cells. 10 It has been shown that catabolites of Trp, including kynurenine, 3-hydroxykynurenine, and 3-hydroxyanthranilic acid, induce apoptosis in Th1 cells, but not in Th2 cells.…”

Section: Introductionmentioning

confidence: 99%

Tryptophan Supplements Promote Pregnancy Success in Mice Challenged with Pseudorabies Virus (PRV) by Regulating the Expression of Systemic Cytokines, Immunoglobulins, PRV-Specific Protein Profiles, and Toll-Like Receptors

Qiu

ZhengFeng

et al. 2011

Journal of Medicinal Food

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Tryptophan (Trp) plays an important role in regulating the maternal immune response, a key determinant of the success or failure of pregnancy, but whether Trp supplements can prevent a pseudorabies virus (PRV)-induced failure of pregnancy remains unknown. This study examined the effect of three dietary Trp levels (0.25%, 0.35%, and 0.5%) on the immunity and reproduction of PRV-challenged pregnant mice. PRV challenge resulted in decreased live embryo numbers, live litter sizes, and serum progesterone and interleukin (IL)-10 concentrations, but increased the levels of serum immunoglobulins (Igs) (PRV-specific antibody [IgG, IgA, and IgM]) and IL-1β. Live embryo numbers, live litter sizes, serum progesterone concentration, and IgG and PRV-specific antibody levels on day 9 of pregnancy were all increased dose-dependently by Trp inclusion in the diet of PRV-challenged mice. Increased Trp levels in PRV-challenged mice promoted the up-regulation of uterine and embryonic indoleamine 2,3-dioxygenase expression, but attenuated the up-regulation of uterine and embryonic Toll-like receptor (TLR) 3 and TLR9 expression and increased serum interferon-γ concentration. Collectively, Trp supplements might improve reproductive performance of PRV-challenged pregnant mice by down-regulating TLR expression and pro-inflammatory cytokine synthesis, by up-regulating PRV-specific antibody and immunoglobulin synthesis, and by elevating the concentrations of anti-inflammatory cytokines and progesterone.

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“…There are differing results about the effects of high doses of methionine on humoral immunity. Bhargava et al (1970) reported that antibody titers to Newcastle disease virus (NDV) were lower in chicks fed diets with adequate methionine than in those with deficient levels of methionine, and similar results were obtained in rats immunized with SRBC (Kenney et al, 1970). However, Swain and Johri (2000) showed that a methionine excess did not alter the antibody response of broiler chickens immunized with SRBC.…”

Section: Introductionmentioning

confidence: 88%

Effects of Liquid dl-2-Hydroxy-4-Methylthio Butanoic Acid on Growth Performance and Immune Responses in Broiler Chickens

Zhang

Guo

2008

Poultry Science

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An experiment was conducted to determine the effects of different doses of liquid dl-2-hydroxy-4-methylthio butanoic acid (LMA) on growth performance and immune response in broiler chickens. In an arrangement with 4 graded levels of LMA to meet 80, 100, 120, and 140% of methionine requirements of broilers recommended by Chinese feeding standards for chickens, 256 one-day-old Arbor Acres male broiler chickens were randomly divided into 4 treatments with 8 replicates of 8 birds each. Growth performance, cellular immunity, and humoral immunity were determined. Results from increasing LMA levels were as follows. There were no significant differences (P > 0.05) in body weight gain and feed intake among the treatments, but the ratio of feed to gain was linearly decreased and significantly greatest (P < 0.05) in the group fed at 80% of methionine requirement. Serum globulin levels on d 21 and 42 were linearly increased significantly (P < 0.05); phagocytosis of neutral red of peripheral blood lymphocyte was quadratic and was lowest in the deficient group (P < 0.05). The proliferation of peripheral blood lymphocytes in response to lipopolysaccharide was quadratically influenced, and that of the 120% group on d 21 and the 100% group on d 42 was significantly greater than in the other groups (P < 0.05). Antibody titers to Newcastle disease virus on d 4 after the first inoculation of the vaccine were quadratically increased, anti-bovine serum albumin antibody production on d 13 after the second immunization was quadratic, and antibody titers were greatest in the groups fed at 100 or 120% of methionine requirement. In conclusion, methionine deficiency resulted in decreased feed utilization and decreased humoral and nonspecific immuno-competence of broiler chickens. The use of LMA to correct a methionine deficiency corrected these problems.

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Dietary Amino Acids and Immune Response in Rats

Cited by 24 publications

References 21 publications

Enhanced Immune Responses in Broiler Chicks Fed Methionine-Supplemented Diets

Enhanced Immune Responses in Broiler Chicks Fed Methionine-Supplemented Diets

Tryptophan Supplements Promote Pregnancy Success in Mice Challenged with Pseudorabies Virus (PRV) by Regulating the Expression of Systemic Cytokines, Immunoglobulins, PRV-Specific Protein Profiles, and Toll-Like Receptors

Effects of Liquid dl-2-Hydroxy-4-Methylthio Butanoic Acid on Growth Performance and Immune Responses in Broiler Chickens

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