Dietary Aloe Improves Insulin Sensitivity via the Suppression of Obesity-induced Inflammation in Obese Mice

Shin, Eunju; Shim, Kyu-Suk; Kong, Hyunseok; Lee, Sung-Won; Shin, Seulmee; Kwon, Jeunghak; Jo, Tae Hyung; Park, Young-In; Lee, Chong-Kil; Kim, Kyungjae

doi:10.4110/in.2011.11.1.59

Cited by 28 publications

(21 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary fatty acids are important regulators of gene expression, acting as intracellular messengers or ligands for transcription factors (Lichtenstein & Schwab 2000, Riccardi et al 2004, Tierney et al 2011 and cause a pronounced tissue-specific regulation of 11b-HSD1 in rodents (Morton et al 2004a, Drake et al 2005, Vara et al 2010. In agreement with previous findings (Shin et al 2011), 11b-hsd1 mRNA expression and enzyme activity was increased in retroperitoneal adipose tissue from rats fed a high-fat diet, regardless of litter size. Notably, hepatic 11b-HSD1 activity was persistently higher in SL rats compared with NL rats, and SL and the high-fat diet exhibited a significant interaction with regard to 11b-HSD1 activity, whereas no changes in hepatic 11b-HSD1 expression and enzyme activity was seen in NL-HF rats, which are similar to the majority of animal models of obesity (Morton et al 2004b, Drake et al 2005.…”

Section: Discussionsupporting

confidence: 90%

The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?

Hou

Wang

et al. 2012

Journal of Endocrinology

View full text Add to dashboard Cite

Early life nutrition is important in the regulation of metabolism in adulthood. We studied the effects of different fatty acid composition diets on adiposity measures, glucose tolerance, and peripheral glucocorticoid (GC) metabolism in overfed neonatal rats. Rat litters were adjusted to a litter size of three (small litters (SLs)) or ten (normal litters (NLs)) on postnatal day 3 to induce overfeeding or normal feeding respectively. After weaning, SL and NL rats were fed a u6 polyunsaturated fatty acid (PUFA) diet (14% calories as fat, soybean oil) or high-saturated fatty acid (high-fat; 31% calories as fat, lard) diet until postnatal week 16 respectively. SL rats were also divided into the third group fed a u3 PUFA diet (14% calories as fat, fish oil). A high-fat diet induced earlier and/or more pronounced weight gain, hyperphagia, glucose intolerance, and hyperlipidemia in SL rats compared with NL rats. In addition, a high-fat diet increased 11b-hsd1 (Hsd11b1) mRNA expression and activity in the retroperitoneal adipose tissue of both litter groups compared with standard chow counterparts, whereas high-fat feeding increased hepatic 11b-hsd1 mRNA expression and activity only in SL rats. SL and a high-fat diet exhibited significant interactions in both retroperitoneal adipose tissue and hepatic 11b-HSD1 activity. Dietary u3 PUFA offered protection against glucose intolerance and elevated GC exposure in the retroperitoneal adipose tissue and liver of SL rats. Taken together, the results suggest that dietary fatty acid composition in the post-sucking period may interact with neonatal feeding and codetermine metabolic alterations in adulthood.

show abstract

Section: Discussionsupporting

confidence: 90%

The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?

Hou

Wang

et al. 2012

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Aloe vera attenuated the absorption of glucose in the gastrointestinal tract after consuming food . It also stimulated glucose catabolism and suppressed glucose production . Glucose storage and utilization were enhanced .…”

Section: Discussionmentioning

confidence: 96%

“…A variety of herbs including Aloe vera ( Aloe vera (L.) Burm.f., Xanthorrhoeaceae family) have been used in folk or traditional medicine for diabetes . It has been reported to possess hypoglycaemic activity through direct glucose lowering effect and improving insulin resistance . However, results of clinical trials of the effect of Aloe vera on glycaemic control appear contradictory .…”

Section: What Is Known and Objectivementioning

confidence: 99%

Effect ofAloe veraon glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis

2016

View full text Add to dashboard Cite

SUMMARYWhat is known and Objective: Aloe vera (Aloe vera (L.) Burm.f., Xanthorrhoeaceae family) has long been used in folk or traditional medicine for diabetes. Several studies have been conducted on the effect of Aloe vera on glycaemic control, but the results appear inconsistent. We undertook a systematic review and meta-analysis to assess the effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes. Methods: A comprehensive literature search was conducted through MEDLINE, CENTRAL, CINAHL, Scopus, http://clini caltrials.gov, Web of Science, Proquest, LILACS, HerbMed, NAPRALERT and CNKI to the end of January 2016 without language restriction. Historical search of relevant articles and personal contact with experts in the area were also undertaken. Studies were included if they were (1) randomized controlled trials of Aloe vera aimed at assessing glycaemic control in prediabetes or type 2 diabetes and (2) reporting fasting plasma glucose (FPG) or haemoglobin A 1c (HbA 1c ). Treatment effect was estimated with mean difference in the final value of FPG and HbA 1c between the treatment and the control groups. Results and discussion: Eight trials involving 470 patients (235 each for prediabetes and type 2 diabetes) were included. In prediabetes, Aloe vera significantly improved FPG (mean difference À0Á22 mmol/L, 95% CI À0Á32 mmol/L to À0Á12 mmol/L, P < 0Á0001), with no effect on HbA 1c (mean difference À2 mmol/ mol, 95% CI À5 mmol/mol to 1 mmol/mol). Aloe vera may improve glycaemic control in type 2 diabetes, with a marginal improvement in FPG (mean differences À1Á17 mmol/L, 95% CI À2Á35 mmol/L to 0Á00 mmol/L, P = 0Á05) and a significant improvement in HbA 1c (mean difference À11 mmol/mol, 95% CI À19 mmol/mol to À2 mmol/mol, P = 0Á01). What is new and Conclusions: The current evidence suggests some potential benefit of Aloe vera in improving glycaemic control in prediabetes and type 2 diabetes. However, given the limitations of the available evidence and the high heterogeneity in study results, high-quality, well-powered randomized controlled trials using standardized preparations are needed to quantify any beneficial effects of Aloe vera on glycaemic control.

show abstract

“…whole plant or from some of its components is scanty and only a recent cause of interest (Gutterman & Chauser-Volfson 2000;Beppu et al 2006;Shin et al 2011;Misawa et al 2012). No information is available on the fate of active components from Aloe spp.…”

Section: Introductionmentioning

confidence: 99%

Administration ofAloe arborescenshomogenate to cattle: interaction with rumen fermentation and gut absorption of aloin

Bani

Grossi

Lucini

et al. 2016

Italian Journal of Animal Science

View full text Add to dashboard Cite

Aloe has long been used as a traditional medicine for its numerous beneficial properties, which are mainly ascribed to b-polysaccharides and phenolic compounds including anthraquinones, anthrones and chromones. However, few studies on large animals are currently available. The effect of whole leaf Aloe arborescens homogenate on the in vitro rumen fermentative processes was tested using alfalfa hay and barley meal as substrates. The Aloe homogeneate was added at three different concentrations (0.4, 2.0 and 10.0 g L À1 of fermentation liquid). The same homogenate was dosed (200 g) orally and through the rumen cannula to three rumen cannulated heifers and orally to six lactating dairy cows to measure the rumen degradation of aloin and the transfer of aloin from the gut into the blood, respectively. The Aloe homogenate did not affect in vitro rumen fermentations and feed digestibility. The administration of Aloe homogenate did not negatively affect animal feed intake and health neither on the cannulated heifers nor on the dairy cows. Aloin underwent a rapid degradation in the rumen milieu, and became undetectable 2 h after oral dosage. However, when Aloe homogenate was administered to dairy cows, aloin appeared in blood as early as 2 h after administration, reached a maximum after 4 h (6.2 6 5.8 lg L À1 ) and progressively decreased thereafter. These results suggest that Aloe compounds can be absorbed into the blood and encourage the study of Aloe as a potential nutraceutical in ruminants. Further studies should determine the most effective in vivo dosage. ARTICLE HISTORY

show abstract

Dietary Aloe Improves Insulin Sensitivity via the Suppression of Obesity-induced Inflammation in Obese Mice

Cited by 28 publications

References 32 publications

The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?

The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?

Effect ofAloe veraon glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis

Administration ofAloe arborescenshomogenate to cattle: interaction with rumen fermentation and gut absorption of aloin

Contact Info

Product

Resources

About