“…Numerous studies have implied that the AGE‐RAGE axis contributes to the pathogenesis of chronic diseases, while most of them deal with endogenous AGEs (e.g., AGE‐albumin conjugates), not AGEs directly related to heat‐processed foods or Western‐style diets. In cell cultures, several food‐derived AGEs were shown to activate inflammatory responses via a RAGE‐dependent pathway (Somoza et al., 2005; Van der Lugt et al., 2018; Zill et al., 2003; Zill, Günther, Erbersdobler, Fölsch, & Faist, 2001). In rodent models, high‐dAGE diets deteriorated pathogenesis mediated by RAGE that are associated with diabetes (Borg et al., 2018; Lin et al., 2003), nephropathies (Yeh, Yang, Pai, Wu, & Chen, 2017), vascular dysfunction (Tikellis et al., 2008), nonalcoholic steatohepatitis (Leung et al., 2016), and Alzheimer's disease (Lubitz et al., 2016).…”