Dietary Administration of High Doses of Pterostilbene and Quercetin to Mice Is Not Toxic

Abstract

The aim of this study is to evaluate possible harmful effects of high doses of t-pterostilbene (t-PTER) and quercetin (QUER) in Swiss mice. Mice were fed during 28 days at doses of 0, 30, 300, and 3000 mg/kg body weight/day of t-PTER, QUER, or a mixture of both, t-PTER + QUER, which are equivalent to 5, 50, and 500 times, respectively, the estimated mean human intake of these polyphenols (25 mg/day). Daily oral administration of QUER, t-PTER, or a mixture of both of them did not cause mortality during the experimental period. There were no differences in food and water consumption on sex. No significant body weight gain in the male or female groups was observed. Red blood cell number and the hematocrit increased after polyphenols administration compared to control groups. Biochemical parameters were not affected. Histopathological examination revealed no alterations in clinical signs or organ weight at any dose.

In Vitro and In Vivo Activities of Pterostilbene against Candida albicans Biofilms

“…In addition, it has been reported that dietary administration of a high dose of PTE produced no toxicity in mice. More specifically, 3,000 mg/kg of body weight/day of PTE for 28 days did not affect biochemical or clinical parameters or the organ weights of the tested mice (71). These findings demonstrated that PTE possesses key preclinical characteristics of a potent antibiofilm agent.…”

Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents

“…Multiple studies demonstrate that chronic administration of dietary flavonols, at concentrations as high as 3,000 mg/kg, has no significant toxicity in animal studies (39)(40)(41). Dietary flavonols used in clinical trials have also been well tolerated (41).…”

Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice

“…Based on the ratio of surface area (human/ mouse) and the doses of 25, 50 and 100 mg/kg tested in mice of the present study, the corresponding doses in human are 192.3, 384.6 and 769.2 mg/day. Treating mice with up to 3,000 mg/kg quercetin exhibit no toxicity [43]. Twenty-two patients administrated with 500 mg of quercetin twice a day for 4 weeks experience none negative side effects [37].…”