Dietary acrylamide intake during pregnancy and anthropometry at birth in the French EDEN mother-child cohort study

Kadawathagedara, Manik; Tong, Anna; Heude, Barbara; Forhan, Anne; Munier, Charles; Sirot, Véronique; Botton, Jérémie

doi:10.1016/j.envres.2016.05.019

Cited by 45 publications

(41 citation statements)

References 36 publications

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“…Interestingly, the 2 biomarker studies were also the studies that observed an inverse association with birth head circumference, whereas the study that used a food frequency questionnaire did not. 5 Our study strengthens the body of evidence that acrylamide intake at current dietary levels may have developmental effects. According to the Developmental Origins of Health and Disease hypothesis, suboptimal prenatal development likely predisposes to inferior health throughout life.…”

Section: Discussionsupporting

confidence: 81%

“…Out of the 3 studies, including the current study, that investigated the link with birth head circumference, 5,6 ours is the second study to observe an inverse association between prenatal acrylamide exposure and head circumference.…”

Section: Discussionmentioning

confidence: 65%

“…All 3 studies observed an inverse association between gestational acrylamide exposure and indicators of fetal growth. [4][5][6] The consistency between all 4 studies that have investigated the association thus far and between the studies using food frequency questionnaire data and biomarkers is rather remarkable. All 4 studies adjusted largely for the same covariables that we adjusted for in this study.…”

Section: Discussionmentioning

confidence: 97%

“…3 To date, all of the 3 epidemiological studies that have studied the link between prenatal acrylamide exposure and fetal growth have consistently shown that higher exposure is linked to reduced fetal growth. [4][5][6] In light of these findings, the European Food Safety Authority (EFSA) in its 2015 acrylamide risk assessment called for more epidemiological research on the association between acrylamide intake and birth outcome.…”

mentioning

confidence: 99%

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Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolizing genes

Hogervorst

Vesper²,

Madhloum

et al. 2019

Preprint

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Background Up to now, 3 epidemiological studies have shown clear inverse associations between prenatal acrylamide exposure and birth size. In addition to studying the association between acrylamide and birth size, we investigated the interaction between acrylamide and polymorphisms in acrylamide-metabolising genes, with the aim of probing the causality of the inverse relationship between acrylamide and fetal growth. Methods We investigated the association between prenatal acrylamide exposure (acrylamide and glycidamide to hemoglobin adduct levels (AA-Hb and GA-Hb) in cord blood) and birth weight, length and head circumference in 443 newborns of the ENVIRONAGE (ENVIRonmental influence ON AGEing in early life) birth cohort. In addition, we studied interaction with single nucleotide polymorphism (SNPs) in CYP2E1, EPHX1 and GSTP1, using multiple linear regression analysis. Results Compared to neonates in the lowest quartile of AA-Hb in cord blood, the body weight, length and head circumference of neonates in the highest quartile were -101 grams (95% CI: -208, 7; p for trend = 0.12), -0.13 centimetres (95% CI: -0.62, 0.36; p for trend = 0.69) and -0.41 centimetres (-0.80, -0.01; p for trend = 0.06) lower, respectively. For GA-Hb, the corresponding effect estimates were -222 grams (95% CI: -337, -108; p for trend = 0.001), -0.85 (95% CI: -1.38, -0.33; p for trend = 0.02) and -0.55 (95% CI: -0.98, -0.11; p for trend = 0.01), respectively. The associations for GA-Hb were similar or stronger in newborns of non-smoking mothers. There was no statistically significant interaction between acrylamide exposure and the studied genetic variations but there was a trend of stronger inverse associations with birth weight and head circumference among newborns with homozygous wildtypes alleles for the CYP2E1 SNPS and with variant alleles for a GSTP1 SNP (rs1138272). Conclusions Prenatal dietary acrylamide exposure, specifically in the form of its metabolite glycidamide, was inversely associated with birth weight, length and head circumference. The interaction pattern with SNPs in CYP2E1, although not statistically significant, is an indication for the causality of this association. Other studies are needed to corroborate this finding.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

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Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolizing genes

Hogervorst

Vesper²,

Madhloum

et al. 2019

Preprint

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“…Similarly, the NewGeneris study found that maternal and cord blood levels of acrylamide and its metabolite glycidamide correlated with a reduced birth weight and head circumference 87. Finally, the most recent study found that maternal dietary acrylamide and birth weight showed a significant negative correlation and that dietary intake of acrylamide was significantly higher in small for gestational age (SGA; <10th percentile) newborns 88. Taken together, these results suggest that an increased maternal acrylamide consumption during pregnancy may have the potential to impair fetal growth; however, it still remains to be determined whether SGA as a result of acrylamide exposure in humans is associated with metabolic abnormalities in postnatal life.…”

Section: Food Processingmentioning

confidence: 93%

Early-life chemical exposures and risk of metabolic syndrome

Long

Holloway

2017

DMSO

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The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity.

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The inhibitory effect of Yam polysaccharides on acrylamide‐induced programmed cell death in RAW 264.7 cells

Wang

Han

Wang

et al. 2022

Food Science & Nutrition

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Acrylamide has been well known for its neurotoxicity, genotoxicity, carcinogenicity, etc. Recently, the immunotoxicity of acrylamide has been reported by different research groups, although the underlying mechanisms of acrylamide endangering immune systems have not been fully elucidated. In this study, mouse monocyte–macrophage cells model was used to clarify the toxic mechanism of acrylamide and the inhibitory effect of Yam polysaccharides (YPS) on acrylamide‐induced damage. We found that acrylamide induced RAW 264.7 cell death in a time‐ and concentration‐dependent manner. After acrylamide (2.0, 3.0, 4.0 mmol/L) treatment for 24 h, cell apoptosis, autophagy, and pyroptosis were observed. However, the levels of autophagy and pyroptosis decreased at a high concentration of acrylamide (4.0 mmol/L). Acrylamide upregulated P2X7 expression, but the P2X7 level was not showing a monotone increasing trend. When the P2X7 antagonist was applied, the effect of acrylamide on autophagy and pyroptosis was weakened. Additionally, acrylamide triggered the occurrence of oxidative stress and a decreased nitric oxide (NO) level. However, reactive oxygen species (ROS) generation, the decrease of heme oxygenase‐1 (HO‐1) expression, and the increase of inducible nitric oxide synthase (iNOS) expression were reversed by the inhibition of P2X7. Yam polysaccharides (50.0 μg/ml) significantly inhibited acrylamide‐induced oxidative stress and cell death (including apoptosis, autophagy, and pyroptosis). Yam polysaccharides also effectively reversed the increase of iNOS expression induced by acrylamide. However, Yam polysaccharides promoted the expression of P2X7 rather than prohibit it. These results indicated that acrylamide caused RAW 264.7 cell death due to pro‐apoptosis as well as excessive autophagy and pyroptosis. Apoptosis might be more predominant than autophagy and pyroptosis under a higher concentration of acrylamide (4.0 mmol/L). P2X7‐stimulated oxidative stress was responsible for acrylamide‐induced programmed cell death (PCD), but P2X7 showed limited regulatory effect on apoptosis. Yam polysaccharides with antioxidant activity inhibited acrylamide‐induced cell death (apoptosis, autophagy, and pyroptosis), but exerted limited effect on the acrylamide‐induced P2X7 expression. These findings would offer an insight into elucidating the immunotoxic mechanism of acrylamide and the potential approaches to control its toxicity.

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Dietary acrylamide intake during pregnancy and anthropometry at birth in the French EDEN mother-child cohort study

Cited by 45 publications

References 36 publications

Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolizing genes

Cord blood acrylamide levels and birth size, and interactions with genetic variants in acrylamide-metabolizing genes

Early-life chemical exposures and risk of metabolic syndrome

The inhibitory effect of Yam polysaccharides on acrylamide‐induced programmed cell death in RAW 264.7 cells

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