Dietary Acrylamide Intake and Brain Cancer Risk

Abstract

Background: Acrylamide is a probable human carcinogen, which is present in several heat-treated foods. In epidemiologic studies, positive associations with endometrial, ovarian, and renal cell cancer risk have been observed. The incidence of central nervous system tumors was increased upon acrylamide administration in drinking water to rats. In the current study, the association between dietary acrylamide intake and human brain cancer risk was investigated for the first time. Methods: In 1986, 120,852 persons (ages 55-69 years) were included in the Netherlands Cohort Study on diet and cancer. At baseline, a random subcohort of 5,000 participants was randomly selected from the total cohort for a case-cohort approach. Acrylamide intake was assessed with a food frequency questionnaire at baseline and based on acrylamide analyses in relevant

Acrylamide inhibits cellular differentiation of human neuroblastoma and glioblastoma cells

“…These DNA adducts cause depurinating lesions, and the repair of these lesions can also lead to the formation of DNA breaks (Friedberg et al, 1995;Martins et al, 2007). In a study that followed human subjects for a period of 13.3 years, a positive association between dietary acrylamide and renal cell cancer risk was found (Hogervorst et al, 2008), and increasing incidences of endometrial, ovarian, and renal cancer with increased dietary ACR intake have also been reported (Hogervorst et al, 2009). Moreover, ACR-induced neurological symptoms followed by neuropathy have been reported in a cohort study of occupationally exposed workers (He et al, 1989).…”

Risk factors for gliomas. An extensive review

“…Dietary minerals, especially calcium and zinc, have protective effects against tumors, including gliomas (68,69). No correlation between acrylamide, present in several heat-prepared foods and glioma risk was found by a study (70).…”

Acrylamide and 5-hydroxymethylfurfural (HMF): A review on metabolism, toxicity, occurrence in food and mitigation strategies

“…The earliest epidemiological studies have failed in finding an association between acrylamide dietary intake and an increased risk of cancer whereas some of the latest epidemiological studies have reported an increased risk for some kinds of cancer. Up to date, the outcomes of these epidemiological studies agree in indicating no positive association between total dietary acrylamide intake and risk of colorectal cancer (Hogervorst, Schouten, Konings, Goldbohm, & van den Brandt, 2008a;Larsson, Kesson, Bergkvist, & Wolk, 2009;Mucci, Adami, & Wolk, 2006;Mucci, Dickman, Steineck, Adami, & Augustsson, 2003;Pelucchi et al, 2006), bladder cancer (Hogervorst, Schouten, Konings, Goldbohm, & van den Brandt, 2008b;Mucci et al, 2003), esophageal cancer (Hogervorst et al, 2008a;Pelucchi et al, 2006), prostate cancer (Hogervorst et al, 2008a;Larsson, Akesson, & Wolk, 2009b;Pelucchi et al, 2006;Wilson et al, 2008), oropharyngeal (Pelucchi et al, 2006), laryngeal (Pelucchi et al, 2006), pancreatic (Hogervorst et al, 2008a), gastric (Hogervorst et al, 2008a) and brain cancer (Hogervorst, Schouten, Konings, Goldbohm, & van den Brandt, 2009a). For renal cell cancer, ovarian cancer, and breast cancer, the results from epidemiological studies are conflicting.…”