Dietary Acid Load in Gluten-Free Diets: Results from a Cross-Sectional Study

Storz, Maximilian Andreas; Ronco, Álvaro L.; Lombardo, Mauro

doi:10.3390/nu14153067

Cited by 5 publications

(3 citation statements)

References 34 publications

(53 reference statements)

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“…По данным H. Satış и соавт. (2021) [13], у пациентов с COVID-19 уровень ИЛ-18 коррелировал с концентрацией ИЛ-6, а базальный уровень ИЛ-18 оказался прогностическим маркером тяжелого течения заболевания. Однако, в доступной литературе отсутствуют данные об уровнях ИЛ-18 у пациентов в различные периоды после перенесенного COVID-19.…”

Section: Discussionunclassified

Immunological Markers in Patients with Gastroenterological Manifestations During Different Periods of COVID-19

Sadretdinova,

Gantseva,

Itkulov

et al. 2024

Arhivʺ vnutrennej mediciny

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Materials and Methods. A retrospective study of 785 medical records of patients hospitalized between 05.2020 and 12.2020 with a diagnosis of moderate to severe new coronavirus COVID-19 infection was performed in phase I. The study was conducted. The primary objective was to evaluate clinical symptoms with a focus on detecting gastroenterologic manifestations of COVID-19. After discharge from the Covid hospital in 3, 6 and 12 months, a telephone questionnaire was conducted using a specially developed questionnaire by the staff of the Department of Internal Medicine of the FSBEU VO BSMU of the Ministry of Health of the Russian Federation to identify gastroenterological symptoms, as well as using the standard questionnaire for the assessment of gastrointestinal symptoms GSRS (Gastrointestinal Symptom Rating Scale) and the Bristol Stool Assessment Scale. 247 respondents took part in the survey, after which they were divided into 3 groups according to the criterion of presence and duration of gastrointestinal symptoms. Group 1 — patients with persisting gastrointestinal symptoms in the period from 4 to 12 weeks (ongoing symptomatic COVID) — 30 people; Group 2 — patients with duration of gastrointestinal symptoms more than 12 weeks (post-COVID syndrome) — 75 people. The control group (group 3) consisted of 151 patients who had survived COVID-19 without the development of postcoviral syndrome. At stage II, serum concentrations of immunologic markers (interleukins 4, 6, 8, 18; rheumatoid factor, antibodies to DNA,) were studied in each group of patients.Results. There was a statistically significant increase in the mean age in group 1 and group 2 patients (p=0.02*10-4 and p=0.01*10-9), as well as in the duration of hospitalization in group 1 patients compared to the control group (p=0.04). Women predominated in both groups 1 (p=0.01) and 2 (p=0.002). The time of outpatient treatment before hospitalization averaged 8.1 days. In both groups of patients there was a statistically significant increase in IL-18 level (p=0,095; p=0,88*10-9), in group 2 there was an increase in rheumatoid factor level (p=0,044) in comparison with the control group. A statistically significant increase in IL-6 levels was also revealed in both studied groups in comparison with the control group (p=0,020; p=0,000017), while the mean values were within the reference intervals.Conclusions. Thus, patients who have had moderate to severe COVID-19 are susceptible to the development of post-Covid syndrome, including gastroenterological manifestations. For the first time, an elevated level of IL-18 was detected in this category of patients, which can serve as both a diagnostic marker and a potential target for targeted therapy.

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Section: Discussionunclassified

Immunological Markers in Patients with Gastroenterological Manifestations During Different Periods of COVID-19

Sadretdinova,

Gantseva,

Itkulov

et al. 2024

Arhivʺ vnutrennej mediciny

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“…Te PRAL value is the most commonly used estimate for the amount of acid or base a certain food produces in the human body [17,18]. Low PRAL values indicate that a specifc food is abundant in base precursors, whereas high values indicate that a food is rich in acid precursors [19,20]. Typical examples of acidifying high-PRAL foods include fsh, cheese, and meats [21,22].…”

Section: Introductionmentioning

confidence: 99%

Macroalgae as Alkalizing Marine Drugs with a Low Potential Renal Acid Load

Storz

2024

Journal of Food Biochemistry

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A growing interest in more sustainable and alternative food sources has brought seaweed and macroalgae to the spotlight for the general worldwide cuisine. Algae are often praised for their high nutritional value and are rich in potassium, calcium, and magnesium. Abundant in base precursors, algae are particularly interesting from an acid-base perspective. Their unique biochemical composition suggests a low potential renal acid load (PRAL), which is a commonly used estimate for the amount of acid or base a certain food produces in humans. Here, we analyzed the PRAL value of n = 106 macroalgae. Results suggested a strong alkalizing potential, with a mean PRAL value of −86.76 mEq/100 g. The lowest PRAL values were found for Laminaria ochroleuca (−286.78 mEq/100 g), Gelidium micropterum (−268.46 mEq/100 g), and Palmaria palmata (−259.16 mEq/100 g). We observed a strong inverse relationship of PRAL with algae’s potassium content (Spearman’s rho = −0.79, p<0.001) and a moderate relationship with algae’s calcium content (Spearmen’s rho: −0.34, p<0.001). Our data point at a potential role for several macroalgae as potent alkalizing marine drugs and suggest that a 10 g edible portion of some algae alone could contribute to a substantial PRAL reduction of up to −28.68 mEq. This might be of particular importance for individuals who benefit from a more alkaline diet and warrants further investigation in future studies.

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“…Dietary modifications are an effective means to reduce the burden of alimentary acid load (12) . A frequent consumption of acid-inducing foods (processed meats, cheese and certain acidifying grains) combined with a low intake of base-inducing foods (fruits, legumes and vegetables) increases DAL (13)(14)(15) . Plant-based diets (PBDs) that are naturally low in (or exclude) animal products have been shown to reliably reduce DAL (14) .…”

Section: Introductionmentioning

confidence: 99%

Observational and clinical evidence that plant-based nutrition reduces dietary acid load

2022

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Contemporary diets in Western countries are largely acid-inducing and deficient in potassium alkali salts, resulting in low-grade metabolic acidosis. The chronic consumption of acidogenic diets abundant in animal-based foods (meats, dairy, cheese and eggs) poses a substantial challenge to the human body's buffering capacities and chronic retention of acid wherein the progressive loss of bicarbonate stores can cause cellular and tissue damage. An elevated dietary acid load (DAL) has been associated with systemic inflammation and other adverse metabolic conditions. In this narrative review, we examine DAL quantification methods and index observational and clinical evidence on the role of plant-based diets, chiefly vegetarian and vegan, in reducing DAL. Quantitation of protein and amino acid composition and of intake of alkalising organic potassium salts and magnesium show that plant-based diets are most effective at reducing DAL. Results from clinical studies and recommendations in the form of expert committee opinions suggest that for a number of common illnesses, wherein metabolic acidosis is a contributing factor, the regular inclusion of plant-based foods offers measurable benefits for disease prevention and management. Based on available evidence, dietary shifts toward plant-based nutrition effectively reduces dietary-induced, low-grade metabolic acidosis.

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Dietary Acid Load in Gluten-Free Diets: Results from a Cross-Sectional Study

Cited by 5 publications

References 34 publications

Immunological Markers in Patients with Gastroenterological Manifestations During Different Periods of COVID-19

Immunological Markers in Patients with Gastroenterological Manifestations During Different Periods of COVID-19

Macroalgae as Alkalizing Marine Drugs with a Low Potential Renal Acid Load

Observational and clinical evidence that plant-based nutrition reduces dietary acid load

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