Dieta Intermitente Atenua a Remodelação Cardíaca Causada pelo Exercício Físico

Abstract

Background: The effects of non-pharmacological interventions such as calorie restriction and exercise training on health and prevention of cardiovascular diseases have been investigated in clinical and experimental studies. Objective: To analyze the influence of intermittent fasting and exercise training on functional fitness, glycemia and cardiac remodeling. Methods: Wistar rats (n=60) were randomly divided into four groups: control, exercise training (ET), intermittent fasting (IF) and exercise training plus intermittent fasting (ETI). Over 12 weeks, control and ET animals were fed daily a standard commercial diet ad libitum, while IF and ETI animals were fed every other day. In addition, the ET and ETI groups were submitted to a running protocol on a treadmill. After this period, functional fitness, nutritional parameters and blood glucose levels were analyzed. In addition to heart morphology, myocardial protein expression of extracellular signalregulated kinase (ERK) and c-Jun N-terminal kinase (JNK) was assessed by Western-blot. The results were analyzed using two-way ANOVA and Student-Newman-Keuls test. The level of significance considered was 5%. Results: Exercise training increased functional fitness in the ET and ETI groups and promoted cardiac fibrosis. The combination of intermittent fasting and exercise training resulted in a smaller area under the blood glucose curve and reduced cardiomyocyte cross-sectional area and interstitial collagen fraction in the ETI group compared to ET. ERK and JNK expression levels were similar among groups (p>0.05). Conclusions: Intermittent fasting is associated with improved glucose tolerance and attenuates cardiac remodeling induced by exercise training (Arq Bras Cardiol. 2020; 115(2):184-193

Intermittent Fasting and Physical Exercise for Preventing Metabolic Disorders through Interaction with Gut Microbiota: A Review

“…Noteworthy, ample experimental evidence has indicated that the combination of exercise and IF lead to a greater improvement of metabolic parameters ( Figure 2 and Table 1 ). The interaction between IF and exercise may have potentiated the hormonal effects of insulin metabolism and is associated with higher glycemic tolerance, which is attributed to the increase in AMPK activity and GLUT4 protein [ 71 ]. In a 3-month randomized parallel-arm trial, the results demonstrated that ADF combined with aerobic exercise was effective for reducing intrahepatic triglycerides in adults with obesity and NAFLD [ 72 ].…”

Effects of Creatine Supplementation on the Myostatin Pathway and Myosin Heavy Chain Isoforms in Different Skeletal Muscles of Resistance-Trained Rats

“…After that, muscle samples were immediately frozen in liquid nitrogen and stored at −80 • C until analysis. The right tibia was dissected, measured using a pachymeter, and used to normalize muscle mass [41,42].…”

“…Protein levels were analyzed by Western blot according to previous studies [41][42][43][44]. Protein was extracted using a RIPA buffer (1 mL/100 mg tissue) containing protease and phosphatase inhibitors.…”

O Melhor do Ano 2020 nos Arquivos Brasileiros de Cardiologia e na Revista Portuguesa de Cardiologia

“…As taxas de mortalidade padronizadas por idade para DCV atribuíveis a fatores de risco em 2018, no Brasil, para mulheres e homens, classificam os riscos dietéticos no segundo lugar do ranking , atrás apenas da hipertensão arterial. 9 Basilio et al 10 estudaram a influência da combinação da dieta intermitente (com restrição calórica) e exercício físico sobre a capacidade funcional, o metabolismo glicêmico e a remodelação cardíaca em ratos Wistar machos, durante 12 semanas. Sua hipótese era que o exercício físico ampliaria o desempenho físico e atenuaria a remodelação miocárdica decorrente da restrição calórica intermitente.…”

“…Estudo comparativo da doença coronariana microvascular causada por doença de Chagas com outras etiologias http://abccardiol.org/wp‐content/uploads/articles_xml/0066‐782X‐abc‐115‐06‐1094/0066‐782X‐abc‐115‐06‐1094.x64000.pdf Stefan 32 7. Quantificação de dano em DNA em diferentes tecidos em ratos com insuficiência cardíaca http://abccardiol.org/wp‐content/uploads/articles_xml/0066‐782X‐abc‐S0066‐782X2020000200234/0066‐782X‐abc‐S0066‐782X2020000200234‐pt.x64000.pdf Basilio 10 8. Dieta intermitente atenua a remodelação cardíaca causada pelo exercício físico http://abccardiol.org/wp‐content/uploads/articles_xml/0066‐782X‐abc‐115‐02‐0184/0066‐782X‐abc‐115‐02‐0184.x64000.pdf Santos 12 9.…”