Diet, weight gain, and circulating micro-nutrients: Evidence for nutritional depletion following adolescent pregnancy

Hediger, Mary L.; Scholl, Theresa O.; Khoo, Chor-San; Fischer, Richard

doi:10.1016/1054-139x(92)90262-a

Cited by 2 publications

(2 citation statements)

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“…14 15 During gestation, the amount of FA ingested is insufficient to supply the daily needs that are increased in the pregnant. 16 Such vitamin has a fundamental role on cell proliferation, interfering in erythrocyte increasing, uterus enlargement, and development of both placenta and fetus, 17 becoming indispensable during pregnancy. According to Rangel-Rivera and Osma-Zambrano, 18 FA is essential for suitable formation and maintenance of several structures of the central nervous system, reducing the risk of severe language and attention disorders, schizophrenia, pre-eclampsia, low birth weight and premature birth.…”

Section: Introductionmentioning

confidence: 99%

“…Gestation is featured by physical and psychological changes, as result of body adaptations, 31 becoming the nutritional needs increased during such period. 16 Maternal nutritional state is pivotal to determine both metabolic and hormonal profile of descendants and stablish conditions which can remain throughout life. Waterland e Garza 32 defined this relationship as fetal programming, expression which associates nutritional changes in early life to diseases in adulthood, such as diabetes, obesity and arterial hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Fernandes

Conde

Brasil

et al. 2023

Rev Bras Ginecol Obstet

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Supplementation with folic acid (FA) during gestation has been recommended by medical society all over the world, but some studies have shown that intake of high folic acid diet may unleash damages to the descendants. Objectives: Describing the effects of maternal supplementation with FA during gestation on offspring's kidney at late life stages. Data Source: It is a systematic review by which were consulted the following databases: Medline, through Pubmed, Lilacs, and SciELO. The research was performed using the keywords “Folic acid”, “Gestation” and “Kidney”. Study Selection: Eight studies were regarded for this systematic review. Data Collection: Only studies that evaluated folic acid consumption during gestation and its effects exclusively on descendants' kidney at several phases of life were regarded. Results: Gestational FA intake did not change the renal volume, glomerular filtration rate and the expression of some essential genes in the kidney of puppies whose dams were supplemented with FA. Maternal consumption of double FA plus selenium diet was effective in preserving antioxidant enzymes activity in the kidney of descendants from mothers exposed to alcohol. FA supplementation decreased some gross anomalies in the puppies caused by teratogenic drug despite of had not been effective in preventing some renal architectural damages. Conclusion: FA supplementation did not cause renal toxicity; it exerted an antioxidant protective effect and mitigated some renal disorders caused by severe aggressions.

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