Diet supplemented with curcumin for nursing lambs improves animal growth, energetic metabolism, and performance of the antioxidant and immune systems

Molosse, Vitor L.; Souza, Carine F.; Baldissera, Matheus D.; Glombowsky, Patrícia; Campigotto, Gabriela; Cazaratto, Chrystian J.; Stefani, Lenita M.; Silva, Aleksandro S. Da

doi:10.1016/j.smallrumres.2018.11.014

Cited by 39 publications

(31 citation statements)

References 23 publications

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“…Curcumin also induces the expression of Nrf2, an antioxidant regulator (Tapia et al 2012) that in turn increases levels of antioxidant enzymes such as GST, catalase, superoxide dismutase (Cardozo et al 2013), GPx and GR, as noted here. Taken together, these data support the hypothesis that curcumin is capable of protecting cells and decreasing lipid peroxidation by increasing antioxidant capacity against peroxyl radicals, as previously described in lactating lambs (Molosse et al 2019).…”

Section: Discussionsupporting

confidence: 91%

“…Curcumin dietary supplementation was associated with increased weight gain in the present experiment, a finding that is possibly related to its anti-inflammatory and antibacterial effects (Jungbauer and Medjakovic 2012;Fu et al 2014), increased intestinal villi (Rahmani et al 2018), higher digestibility of fiber (Jaguezeski et al 2018) and stimulation of energy metabolism and antioxidant system (Molosse et al 2019).…”

Section: Discussionsupporting

confidence: 51%

“…Curcumin is thought to be an important additive with anti-inflammatory properties (Jaguezeski et al 2018;Molosse et al 2019;de Almeida et al 2018;Jungbauer and Medjakovic 2012;Fu et al 2014). In this study, curcumin reduced the number of total leukocytes, erythrocytes, and lymphocytes, all of which are inflammatory cells that are not desirable for farm animals at high levels, because active inflammatory processes consume large amounts of ATP that are consequently no longer usable for weight gain or production.…”

Section: Discussionmentioning

confidence: 89%

“…According to the literature, Curcuma longa contains curcuminoids as active components and these act by modulating the immune and antioxidant systems (Yarru et al 2009), reducing inflammatory processes and eliminating excess free radical production; as a result, there is less oxidative stress during the growth (Srinivasan and Sambaiah, 1991). Molosse et al (2019) observed that the addition of curcumin to the diet of lactating lambs increased weight gain, as well as induces anti-inflammatory and antioxidant effects, all of which are desirable biological benefits that enhance production. The antimicrobial effects of curcumin are also desirable.…”

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confidence: 99%

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Effect of curcumin dietary supplementation on growth performance, physiology, carcass characteristics and meat quality in lambs

Marcon

Souza

Baldissera

et al. 2021

Annals of Animal Science

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This study evaluated the effects of curcumin dietary supplementation on growth, physiology, carcass characteristics and meat quality in lambs. Thirty-two male Lacaune lambs (15.6 ± 0.63 kg, 60 ± 2.8 days of age) were randomly allocated in 16 pens (four treatments of four replicates with two lambs each) for 30 days. The animals were assigned to the following treatments: T0, T100, T200 and T300, representing 0, 100, 200 and 300 mg of curcumin/kg of concentrate, respectively. Curcumin dietary supplementation increased (P = 0.02) weight gain; on regression analysis, 315.1 mg curcumin/kg of concentrate was the dosage that provided the greatest weight gain. T200 and T300 lambs had lower (P = 0.04) erythrocytes numbers; T100 and T300 lambs had lower (P = 0.01) leukocyte numbers and T300 lambs had lower (P = 0.04) lymphocyte numbers, compared to T0 lambs. Globulin levels were significantly greater in the T200 group (P = 0.04) only on day 15 but not day 30; levels of total protein were significantly higher (P = 0.01) only in T200 and T300 group on day 15 and only in T200 group on d 30. Gamma-glutamyltransferase concentrations tended to be lower (P = 0.08) in T100, T200 and T300 group on d 15, and only in the T100 group on d 30. Curcumin dietary supplementation increased (P = 0.01) the serum activity of antioxidant enzymes and reduced (P = 0.01) levels of reactive oxygen species. In meat samples, T200 and T300 had greater total antioxidant capacity (P = 0.03) and lower (P = 0.01) lipoperoxidation rates. In carcasses, T300 lambs had greater (P ≤ 0.02) cooling weight losses and yields than did T0 lambs. Curcumin dietary supplementation also reduced (P ≤ 0.03) redness and yellowness. T200 and T300 lambs had fewer (P = 0.01) cooking losses and T200 lambs had greater (P = 0.03) water holding capacity than did T0 lambs. These findings suggest that curcumin dietary supplementation improves growth and antioxidant responses, as well as influencing meat quality in lambs.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of curcumin dietary supplementation on growth performance, physiology, carcass characteristics and meat quality in lambs

Marcon

Souza

Baldissera

et al. 2021

Annals of Animal Science

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“…In the livestock, curcumin has been used to improve the enzyme activity, performance, egg quality, and anti-oxidative state [27,28,29]. It has been reported that nursing lambs fed diets with curcumin can significantly improve daily weight gain, production performance, metabolism, and immune performance [30].…”

Section: Introductionmentioning

confidence: 99%

Effect of Curcumin Supplement in Summer Diet on Blood Metabolites, Antioxidant Status, Immune Response, and Testicular Gene Expression in Hu Sheep

Jiang

Wan

Yang

et al. 2019

Animals

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Simple SummaryHeat stress can induce oxidative stress and has an adverse effect on the growth and reproductive performance in animals. Curcumin, a plant-derived substance, with the effect of scavenging oxidative free radicals, improving immune response and anti-apoptosis, has been widely used as a dietary supplement in the livestock industry. The present study aims to investigate the effect of a curcumin dietary supplement on the blood metabolites, antioxidant status, immune response, and testicular gene expression in Hu Sheep in summer. The results show that dietary curcumin supplementation (450 and 900 mg/per sheep daily) can promote lipid metabolism, antioxidant capacity, and immune response as well as testicular development in Hu sheep, which provides evidence for the protective role of curcumin against heat stress in sheep.AbstractIn summer, the high temperature affects animal growth and reproductive performance. Curcumin is a flavonoid with anti-oxidant and anti-inflammatory effects. To evaluate the effects of dietary curcumin supplement on the blood biochemical parameters and testicular gene expressions in Hu sheep in summer, a total of 144 male Hu sheep aged four months were randomly divided into three groups (Con, Cur1, and Cur2, n = 48). Sheep in Con, Cur1, and Cur2 groups were fed a basal diet supplement with 0, 450, and 900 mg (per sheep) curcumin daily, respectively. Sheep were fed for 35 days, including a pre-feed for seven days. The results showed that the supplement with 450 mg and 900 mg curcumin increased serum free fatty acid (NEFA) and glutathione peroxidase (GPX), as well as IgA and IgM. The supplement with 450 mg curcumin increased the IgG level, while the supplement with 900 mg curcumin had a lower IgG level than the supplement with 450 mg curcumin (p < 0.05). Dietary curcumin supplement increased testicular organ index, serum testosterone level, and testicular star mRNA expression (p < 0.05). Furthermore, dietary curcumin supplement linearly inhibited testicular apoptosis with increased testicular bcl-2 mRNA expression and decreased caspase-3 mRNA expression (p < 0.05). In conclusion, dietary curcumin supplement can promote lipid metabolism, antioxidant capacity, and immune response, as well as testicular development, in Hu sheep, which provides evidence of application of curcumin in sheep production.

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Intake of snacks containing curcumin stimulates erythropoiesis and antioxidant response in dogs

et al. 2020

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Diet supplemented with curcumin for nursing lambs improves animal growth, energetic metabolism, and performance of the antioxidant and immune systems

Cited by 39 publications

References 23 publications

Effect of curcumin dietary supplementation on growth performance, physiology, carcass characteristics and meat quality in lambs

Effect of curcumin dietary supplementation on growth performance, physiology, carcass characteristics and meat quality in lambs

Effect of Curcumin Supplement in Summer Diet on Blood Metabolites, Antioxidant Status, Immune Response, and Testicular Gene Expression in Hu Sheep

Intake of snacks containing curcumin stimulates erythropoiesis and antioxidant response in dogs

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