Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice

Kostovcikova, Klara; Coufal, Štěpán; Galanová, Natalie; Fajstová, Alena; Hudcovic, Tomáš; Kostovčík, Martin; Procházková, Petra; Zákostelská, Zuzana Jirásková; Cermáková, M; Šedivá, Blanka; Kuzma, Marek; Tlaskalová‐Hogenová, Helena; Kverka, Miloslav

doi:10.3389/fimmu.2019.00919

Cited by 84 publications

(76 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If the subjects consume the same diet, designed by a nutritionist or dietarian with standard formula, the result will be more promising and innovative. Some studies have reported that specific kinds of dietary fiber intake can lead to various results [ 29 , 30 ]. Athletes in groups who share diet and exercise patterns can lead to advanced results on the correlation between exercise and gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Athletes’ Probiotic Intake May Depend on Protein and Dietary Fiber Intake

Son

Jang

Kim³

et al. 2020

Nutrients

View full text Add to dashboard Cite

Studies investigating exercise-induced gut microbiota have reported that people who exercise regularly have a healthy gut microbial environment compared with sedentary individuals. In contrast, recent studies have shown that high protein intake without dietary fiber not only offsets the positive effect of exercise on gut microbiota but also significantly lowers the relative abundance of beneficial bacteria. In this study, to resolve this conundrum and find the root cause, we decided to narrow down subjects according to diet. Almost all of the studies had subjects on an ad libitum diet, however, we wanted subjects on a simplified diet. Bodybuilders who consumed an extremely high-protein/low-carbohydrate diet were randomly assigned to a probiotics intake group (n = 8) and a placebo group (n = 7) to find the intervention effect. Probiotics, comprising Lactobacillus acidophilus, L. casei, L. helveticus, and Bifidobacterium bifidum, were consumed for 60 days. As a result, supplement intake did not lead to a positive effect on the gut microbial environment or concentration of short-chain fatty acids (SCFAs). It has been shown that probiotic intake is not as effective as ergogenic aids for athletes such as bodybuilders with extreme dietary regimens, especially protein and dietary fiber. To clarify the influence of nutrition-related factors that affect the gut microbial environment, we divided the bodybuilders (n = 28) into groups according to their protein and dietary fiber intake and compared their gut microbial environment with that of sedentary male subjects (n = 15). Based on sedentary Korean recommended dietary allowance (KRDA), the bodybuilders′ intake of protein and dietary fiber was categorized into low, proper, and excessive groups, as follows: high-protein/restricted dietary fiber (n = 12), high-protein/adequate dietary fiber (n = 10), or adequate protein/restricted dietary fiber (n = 6). We found no significant differences in gut microbial diversity or beneficial bacteria between the high-protein/restricted dietary fiber and the healthy sedentary groups. However, when either protein or dietary fiber intake met the KRDA, gut microbial diversity and the relative abundance of beneficial bacteria showed significant differences to those of healthy sedentary subjects. These results suggest that the positive effect of exercise on gut microbiota is dependent on protein and dietary fiber intake. The results also suggest that the question of adequate nutrition should be addressed before supplementation with probiotics to derive complete benefits from the intervention.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Athletes’ Probiotic Intake May Depend on Protein and Dietary Fiber Intake

Son

Jang

Kim³

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…The relationship between protein intake and gut microbiota composition has been investigated in several animal studies, giving conflicting results [78][79][80][81][82][83][84][85]. Rats fed a high-protein diet exhibited pro-inflammatory changes in gut microbiota composition, with an overrepresentation of pathobionts, such as Escherichia/Shigella and Enterococcus, depletion of species associated with the synthesis of short-chain fatty acids (SCFAs), such as Faecalibacterium, and protection of mucosa, such as Akkermansia [78,79]. These alterations of gut microbiota composition were emphasized when proteins were of animal origin [80].…”

Section: Animal Proteins and Microbiotamentioning

confidence: 99%

Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

et al. 2020

View full text Add to dashboard Cite

Recent studies have shown that patients with kidney stone disease, and particularly calcium oxalate nephrolithiasis, exhibit dysbiosis in their fecal and urinary microbiota compared with controls. The alterations of microbiota go far beyond the simple presence and representation of Oxalobacter formigenes, a well-known symbiont exhibiting a marked capacity of degrading dietary oxalate and stimulating oxalate secretion by the gut mucosa. Thus, alterations of the intestinal microbiota may be involved in the pathophysiology of calcium kidney stones. However, the role of nutrition in this gut-kidney axis is still unknown, even if nutritional imbalances, such as poor hydration, high salt, and animal protein intake and reduced fruit and vegetable intake, are well-known risk factors for kidney stones. In this narrative review, we provide an overview of the gut-kidney axis in nephrolithiasis from a nutritional perspective, summarizing the evidence supporting the role of nutrition in the modulation of microbiota composition, and their relevance for the modulation of lithogenic risk.

show abstract

“…These include members of the Cystobasidiomycetes class (with emphasis on the species Cystobasidium sloofiae) and representatives [wuc] of the Sporidiobolaceae family. Although there are few reports regarding the involvement of these fungal groups with diseaseassociated dysbioses, increased populations of Sporidiobolaceae have been detected in cervical mucosa lesions from HPV-infected women at low risk of malignancy (106), as well as in the intestine of mice submitted to diets rich in animal proteins (107). Moreover, the relative abundance of Cystobasidiomycetes was positively correlated with adiposity, while negatively correlated with the serum concentration of LDL cholesterol in obese and lean subjects (69).…”

Section: Discussionmentioning

confidence: 99%

Fungal Dysbiosis Correlates With the Development of Tumour-Induced Cachexia in Mice

Jabès

Maria

Barbosa

et al. 2020

Preprint

View full text Add to dashboard Cite

ABSTRACTCachexia (CC) is a devastating metabolic syndrome associated with a series of underlying diseases that greatly affects life quality and expectancy among cancer patients. Studies involving mouse models, in which CC was induced through inoculation with tumor cells, originally suggested the existence of a direct correlation between the development of this syndrome and changes in the relative proportions of several bacterial groups present in the digestive tract. However, these analyses have focus solely on the characterization of bacterial dysbiosis, ignoring the possible existence of changes in the relative populations of fungi, during the development of CC. Thus, the present study sought to expand such analyses, by characterizing changes that occur in the gut fungal population (mycobiota) of mice, during the development of cancer-induced cachexia. Our results confirm that cachectic animals display significant differences in their gut mycobiota, when compared to healthy controls. Moreover, identification of dysbiotic fungi showed remarkable consistency across successive levels of taxonomic hierarchy. Many of these fungi have also been associated with dysbioses observed in a series of gut inflammatory diseases, such as obesity, Colorectal Cancer (CRC), Myalgic Encephalomyelitis (ME) and Inflammatory Bowel Disease (IBD). Nonetheless, the CC-associated dysbiosis seems to be unique, presenting features observed in both obesity (reduced proportion of Mucoromycota) and CRC/ME/IBD (increased proportions of Sordariomycetes, Saccharomycetaceae and Malassezia). One species of Mucoromycota (Rhyzopus oryzae) stands out as a promising probiotic candidate in adjuvant therapies, aimed at treating and/or preventing the development of CC.

show abstract

Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice

Cited by 84 publications

References 76 publications

The Effect of Athletes’ Probiotic Intake May Depend on Protein and Dietary Fiber Intake

The Effect of Athletes’ Probiotic Intake May Depend on Protein and Dietary Fiber Intake

Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

Fungal Dysbiosis Correlates With the Development of Tumour-Induced Cachexia in Mice

Contact Info

Product

Resources

About