Diet Quality and Risk of Melanoma in an Italian Population

Malagoli, Carlotta; Malavolti, Marcella; Agnoli, Claudia; Crespi, Catherine M.; Fiorentini, Chiara; Farnetani, Francesca; Longo, Caterina; Ricci, Cinzia; Albertini, Giuseppe; Lanzoni, Anna; Veneziano, Leonardo Squinello Nogueira; Virgili, Annarosa; Pagliarello, Calogero; Santini, Marcello; Fanti, Pier ­Alessandro; Dika, Emi; Sieri, Sabina; Pellacani, Giovanni

doi:10.3945/jn.114.209320

Cited by 40 publications

(44 citation statements)

References 60 publications

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“…We also assessed their dietary habits through a semi-quantitative food frequency questionnaire used for the Central-Northern Italian population within the EPIC study (21). This questionnaire assessed the frequency and amount of consumption of 188 food items over the previous year, and allowed to estimate frequency and quantity of consumption of the individual foodstuff and related intake of nutrients and contaminants through an ad hoc software (22,23). With regard to the intake of such nutrients, we selected only those previously reported to influence Mn content, i.e., iron, calcium and phosphorus (6,7).…”

Section: Methodsmentioning

confidence: 99%

Determinants of serum manganese levels in an Italian population

Filippini

Michalke

Grill

et al. 2017

Molecular Medicine Reports

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Manganese (Mn) is both essential and toxic for humans, mainly depending on the total levels and its species. Main sources of exposure include food and air pollution, particularly motorized traffic. We sought to determine the potential influence of these sources on serum total levels of Mn and Mn species. We selected a random sample of municipality residents from an Italian urban municipality, from whom we collected detailed personal information, dietary habits and a blood sample for serum Mn determination. We also assessed outdoor air Mn exposure, by modeling levels of particulate matter ≤10 µm (PM10) from motorized traffic at the residence of geocoded subjects. Serum Mn species generally showed higher levels in males and positive correlation with age, while no such differences were found according to smoking habits or use of dietary supplements. Among nutrients, only iron intake showed a relation with Mn [an inverse correlation with Mn‑ferritin (Mn‑Fer) and a direct one with inorganic‑Mn (Inorg‑Mn)]. Meat consumption directly correlated and fish and seafood inversely correlated with total Mn, Mn‑transferrin (Mn‑Tf) and Mn-citrate (Mn-Cit). Fruits and vegetables, including legumes and nuts, generally showed a positive correlation with all Mn species, especially Mn‑Cit, and an inverse one with Inorg‑Mn. Odds ratios (ORs) of having serum Mn levels above median value increased with increasing PM10 tertiles, with an OR for highest‑to‑lowest tertile of 7.40 (1.36‑40.25) in multivariate analysis. Analyses for Mn species did not highlight a clear comparable pattern. In conclusion, our results seem to demonstrate that PM10 exposure positively influences total Mn serum levels, while single Mn species show conflicting results.

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Section: Methodsmentioning

confidence: 99%

Determinants of serum manganese levels in an Italian population

Filippini

Michalke

Grill

et al. 2017

Molecular Medicine Reports

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“…We also administered two questionnaires to all study subjects: one collected information on several variables including smoking habits and occupational history, the second investigated dietary habits through a semi-quantitative food frequency questionnaire used for the Central-Northern Italian population within the EPIC study (Pasanisi et al, 2002;Pala et al, 2003). This questionnaire assessed the frequency and amount of consumption of 188 food items over the previous year, and allowed the frequency and quantity of consumption of foodstuffs and the related intake of nutrients and contaminants to be calculated using an ad hoc software (Malavolti et al, 2013;Malagoli et al, 2015). This database included among other trace elements selenium and Cd, and was largely based on chemical analyses of foodstuffs distributed in Northern Italy performed at the University of Modena and Reggio Emilia for both selenium (Vinceti et al, 2015b) and Cd (Bottecchi and Vinceti, 2012;Malavolti et al, 2015).…”

Section: Study Participantsmentioning

confidence: 99%

Determinants of serum cadmium levels in a Northern Italy community: A cross-sectional study

Filippini

Michalke

Malagoli

et al. 2016

Environmental Research

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“…Fortes and colleagues (27) found the Mediterranean diet may have protective effects against melanoma. Malagoli and colleagues (88) found an inverse association between melanoma risk with the Healthy Eating Index 2010 (HEI-2010) and Dietary Approaches to Stop Hypertension (DASH) index, which both assess diet quality. These lines of evidence suggested that dietary patterns could affect risk of melanoma.…”

Section: Discussionmentioning

confidence: 99%

An Epidemiological Review of Diet and Cutaneous Malignant Melanoma

Yang

Fung

Nan

2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Incidence of cutaneous malignant melanoma has continued to rise despite public efforts to promote sun protection behaviors among populations at risk. However, dietary factors may also affect the development of melanoma. In the past few decades, findings from epidemiologic and experimental research have linked consumption of several foods and other nutrients to the risk of melanoma. Caffeine has been associated with a lower risk of melanoma, and citrus fruits and alcohol with increased risk. Associations between polyunsaturated fatty acid, niacin/nicotinamide, folate, and vitamin D with melanoma remain controversial. Diet likely influences melanoma development through several potential mechanisms, such as enhancing UV-induced apoptosis and increasing photosensitivity. We conducted a narrative review to summarize recent epidemiologic studies of diet and melanoma based on published literature. Given the high prevalence of the food items and nutrients covered in this review and the decades-long rising melanoma incidence worldwide, the associations we discuss may have important public health implications in terms of reducing melanoma incidence through dietary modification. .

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Diet Quality and Risk of Melanoma in an Italian Population

Abstract: These results suggest that diet quality may play a role in cutaneous melanoma etiology among women.

Cited by 40 publications

References 60 publications

Determinants of serum manganese levels in an Italian population

Determinants of serum manganese levels in an Italian population

Determinants of serum cadmium levels in a Northern Italy community: A cross-sectional study

An Epidemiological Review of Diet and Cutaneous Malignant Melanoma

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