Diet quality and colorectal tumor risk in persons with Lynch syndrome

Eijkelboom, Anouk H; Brouwer, Jesca G.M.; Vasen, Hans F. A.; Bisseling, Tanya M.; Koornstra, Jan J.; Kampman, Ellen; Duijnhoven, Fränzel J.B. van

doi:10.1016/j.canep.2020.101809

Cited by 3 publications

(7 citation statements)

References 52 publications

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“…Some have suggested that diet could explain, at least in part, this degree of variability [ 201 , 202 , 203 ]. Few exploratory studies have investigated this hypothesis [ 204 , 205 , 206 ]. Unfortunately, the results have been largely underwhelming.…”

Section: The Relationship Of Other Risk Factors For Eocrc With Diet and Lifestylementioning

confidence: 99%

“…Unfortunately, the results have been largely underwhelming. In fact, in patients with Lynch syndrome, the diet seems not to have an association with the age of onset of CRC [ 205 , 206 ]. Perhaps Lynch syndrome confers such a high risk of CRC that the diet is not powerful enough to alter the disease course.…”

Section: The Relationship Of Other Risk Factors For Eocrc With Diet and Lifestylementioning

confidence: 99%

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The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review

Puzzono

Mannucci

Grannò

et al. 2021

Cancers

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The incidence of early-onset colorectal cancer, defined as colorectal cancer occurring in young adults under the age of 50, is increasing globally. Knowledge of the etiological factors in young adults is far from complete. Questionable eoCRCs’ exogenous factors are represented by processed meat, sugary drinks, alcohol, Western dietary pattern, overweight and obesity, physical inactivity, and smoking, though with heterogeneous results. Therefore, we performed a systematic review to summarize the current evidence on the role of diet and lifestyle as eoCRC risk factors. We systematically searched PubMed, Scopus, and EMBASE up to July 2021, for original studies evaluating diet, alcohol, physical activity, BMI, and smoking in eoCRC and included twenty-six studies. Indeed, the exogenous factors could represent modifiable key factors, whose recognition could establish areas of future interventions through public health strategies for eoCRC primary prevention. Additionally, we discussed the role of additional non-modifiable risk factors, and of epigenetic regulation and microbiota as mediators of the eoCRC triggered by diet and lifestyle.

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Section: The Relationship Of Other Risk Factors For Eocrc With Diet and Lifestylementioning

confidence: 99%

Section: The Relationship Of Other Risk Factors For Eocrc With Diet and Lifestylementioning

confidence: 99%

The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review

Puzzono

Mannucci

Grannò

et al. 2021

Cancers

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“…Remarkably, lip and oral cavity cancer are the 20th most prevalent cancers in Iran, with a combined risk of 0.144. [1][2][3] The overall burden of lip and oral cavity cancer is increasing over time. Further to statistics reported in the past year, the global new cases are estimated to reach 1,403,985, presenting 55% increase in incidence rate.…”

Section: Lip and Oral Cavitymentioning

confidence: 99%

“…1/January 2022 worldwide. 3 Global Cancer Incidence, Mortality and Prevalence database (GLOBOCAN) release epidemiological statistics for the most common gastrointestinal tract organs annually: lip and oral cancer, esophageal cancer, abdominal cancer, liver and bile duct cancer, gallbladder cancer, pancreatic cancer, and colorectal cancer. Meanwhile, Asia has a substantial number of people with gastrointestinal cancers.…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal and Pancratohepatobiliary Cancers: A Comprehensive Review on Epidemiology and Risk Factors Worldwide

Hormati

Hajrezaei

Jazi

et al. 2022

Middle East J Dig Dis

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A significant number of cancer cases are afflicted by gastrointestinal cancers annually. Lifestyle and nutrition have a huge effect on gastrointestinal function, and unhealthy habits have become quite widespread in recent decades, culminating in the rapid growth of gastrointestinal cancers. The most prevalent cancers are lip and mouth cancer, esophageal cancer, gastric cancer, liver and bile duct cancer, pancreatic cancer, and colorectal cancer. Risk factors such as red meat consumption, alcohol consumption, tea, rice, viruses such as Helicobacter pylori and Ebstein Bar Virus (EBV), along with reduced physical activity, predispose the gastrointestinal tract to damage and cause cancer. According to the rapid increase of cancer incidence and late diagnosis of gastrointestinal malignancies, further epidemiological researches remain necessary in order to make appropriate population-based preventive policies. In this study, we reviewed clinical symptoms, risk factors, preventative measures, as well as incidence and mortality rates of gastrointestinal malignancies worldwide with focus on Iranian population.

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Modifiable risk factors for cancer among people with lynch syndrome: an international, cross-sectional survey

Power,

Doherty,

Horgan

et al. 2024

Hered Cancer Clin Pract

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Background Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancer. Lifestyle modification may provide an opportunity for adjunctive cancer prevention. In this study, we aimed to characterise modifiable risk factors in people with Lynch syndrome and compare this with international guidelines for cancer prevention. Methods A cross-sectional study was carried out utilizing survey methodology. Following public and patient involvement, the survey was disseminated through patient advocacy groups and by social media. Self-reported demographic and health behaviours were collected in April 2023. Guidelines from the World Cancer Research Fund (WCRF) were used to compare percentage adherence to 9 lifestyle recommendations, including diet, physical activity, weight, and alcohol intake. Median adherence scores, as a surrogate for lifestyle risk, were calculated and compared between groups. Results 156 individuals with Lynch syndrome participated from 13 countries. The median age was 51, and 54% were cancer survivors. The mean BMI was 26.7 and the mean weekly duration of moderate to vigorous physical activity was 90 min. Median weekly consumption of ethanol was 60 g, and 3% reported current smoking. Adherence to WCRF recommendations for cancer prevention ranged from 9 to 73%, with all but one recommendation having < 50% adherence. The median adherence score was 2.5 out of 7. There was no significant association between median adherence scores and age (p = 0.27), sex (p = 0.31), or cancer history (p = 0.75). Conclusions We have characterised the modifiable risk profile of people living with Lynch syndrome, outlining targets for intervention based on lifestyle guidelines for the general population. As evidence supporting the relevance of modifiable factors in Lynch syndrome emerges, behavioural modification may prove an impactful means of cancer prevention.

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Diet quality and colorectal tumor risk in persons with Lynch syndrome

Cited by 3 publications

References 52 publications

The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review

The Role of Diet and Lifestyle in Early-Onset Colorectal Cancer: A Systematic Review

Gastrointestinal and Pancratohepatobiliary Cancers: A Comprehensive Review on Epidemiology and Risk Factors Worldwide

Modifiable risk factors for cancer among people with lynch syndrome: an international, cross-sectional survey

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