Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Paris, Tonya; Daly, Robin M; Abbott, Gavin; Sood, Surbhi; Freer, Christine L; Ryan, Marno C; George, Elena S

doi:10.1016/j.advnut.2024.100169

Cited by 4 publications

(2 citation statements)

References 72 publications

(319 reference statements)

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“…Additionally, probiotics were effective for patients with both mild and moderate depression. This fact places probiotics next to nutritional, dietary, and other lifestyle interventions, which may also be effective for mild depressive symptoms [44]. However, our study did not find any significant change in depression scores overall between the probiotics and placebo groups.…”

Section: Changes In Psychometric Datacontrasting

confidence: 69%

Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results

Gawlik-Kotelnicka,

Margulska,

Płeska

et al. 2024

Nutrients

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Probiotics may represent a safe and easy-to-use treatment option for depression or its metabolic comorbidities. However, it is not known whether metabolic features can influence the efficacy of probiotics treatments for depression. This trial involved a parallel-group, prospective, randomized, double-blind, controlled design. In total, 116 participants with depression received a probiotic preparation containing Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 or placebo over 60 days. The psychometric data were assessed longitudinally at five time-points. Data for blood pressure, body weight, waist circumference, complete blood count, serum levels of C-reactive protein, cholesterol, triglycerides, and fasting glucose were measured at the beginning of the intervention period. There was no advantage of probiotics usage over placebo in the depression score overall (PRO vs. PLC: F(1.92) = 0.58; p = 0.45). However, we found a higher rate of minimum clinically important differences in patients supplemented with probiotics than those allocated to placebo generally (74.5 vs. 53.5%; X2(1,n = 94) = 4.53; p = 0.03; NNT = 4.03), as well as in the antidepressant-treated subgroup. Moreover, we found that the more advanced the pre-intervention metabolic abnormalities (such as overweight, excessive central adipose tissue, and liver steatosis), the lower the improvements in psychometric scores. A higher baseline stress level was correlated with better improvements. The current probiotic formulations may only be used as complementary treatments for depressive disorders. Metabolic abnormalities may require more complex treatments. ClinicalTrials.gov identifier: NCT04756544.

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Section: Changes In Psychometric Datacontrasting

confidence: 69%

Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results

Gawlik-Kotelnicka,

Margulska,

Płeska

et al. 2024

Nutrients

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“…Three primary elements contribute to the regulation of body weight: the metabolic processing of nutrients, dietary patterns, and levels of physical activity [ 61 ]. There is strong evidence that balanced diets like low-fat, low-carbohydrate, and Mediterranean diets can help with managing metabolic conditions [ 62 ]. Efforts to prevent obesity should prioritize the maintenance of weight loss or the management of excessive weight gain [ 63 ].…”

Section: Role Of Dietmentioning

confidence: 99%

Influence of Metabolic Dysregulation in the Management of Depressive Disorder—Narrative Review

Jakubowska,

Balcerczyk-Lis,

Fortuna

et al. 2024

Nutrients

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Depressive disorders are heterogeneous in nature, and their global reach makes them the cause of suffering for a million individuals worldwide. Standard treatment does not work for one in three people, and side effects can significantly reduce the quality of life. A multidisciplinary approach allows for a broader insight into the nature of the disease, given its complex etiology. One of its elements is the hypothesis of inflammation, which also accompanies obesity-related disease. Obesity and depression interact, causing many researchers to develop new non-pharmacological treatment methods for both diseases. One suggestion is physical exercises that have great potential to be used in clinical practice. They can exert changes on the central nervous system and thus modulate mood. Another is diet, which concentrates on active molecules that also affect the central nervous system (CNS). There is an urgent need to create appropriate criteria and recommendations that systematize existing knowledge and allow it to be used in practice. There is an urgent need to create appropriate criteria and recommendations that systematize existing knowledge and allow it to be used in practice.

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The Impact of Chronic Diseases on Mental Health: An Overview and Recommendations for Care Programs

Akif,

Qusar,

Islam

2024

Curr Psychiatry Rep

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Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Cited by 4 publications

References 72 publications

Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results

Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results

Influence of Metabolic Dysregulation in the Management of Depressive Disorder—Narrative Review

The Impact of Chronic Diseases on Mental Health: An Overview and Recommendations for Care Programs

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