Diet influence on the gut microbiota and dysbiosis related to nutritional disorders

Alou, Maryam Tidjani; Lagier, Jean‐Christophe; Raoult, Didier

doi:10.1016/j.humic.2016.09.001

Cited by 130 publications

(88 citation statements)

References 61 publications

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“…Other phyla increased in abundance in G and CP patients compared PH were Proteobacteria, Verrucomicrobia and Euryarchaeota . Multiple sclerosis patients have shown to present increased relative abundance of Euryarchaeota and Verrucomicrobia compared to healthy controls [60], whereas Proteobacteria is increased in severe acute malnutrition [61]. Verrucomicrobia is also increased in abundance in dextran sodium sulphate-induced murine colitis [62].…”

Section: Discussionmentioning

confidence: 99%

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Lourenςo

Spencer

Alm

et al. 2018

Journal of Oral Microbiology

117

109

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Background: This exploratory study aimed to characterize the gut microbiome of individuals with different periodontal conditions, and correlate it with periodontal inflammation and tissue destruction.Methods: Stool samples were obtained from individuals presenting periodontal health (PH = 7), gingivitis (G = 14) and chronic periodontitis (CP = 23). The intestinal microbiome composition was determined by Illumina MiSeq sequencing.Results: A lower alpha-diversity in the gut microbiome of individuals with CP was observed, although no significant difference among groups was found (p > 0.01). Firmicutes, Proteobacteria, Verrucomicrobia and Euryarchaeota were increased, whereas Bacteroidetes were decreased in abundance in patients with periodontitis compared to PH. Prevotella (genus), Comamonadaceae (family) and Lactobacillales (order) were detected in higher numbers in G, while Bacteroidales (order) was predominant in PH (p < 0.01). Significant correlations (rho = 0.337–0.468, p < 0.01) were found between OTUs representative of periodontal pathogens and attachment loss. Mogibacteriaceae, Ruminococcaceae and Prevotella were able to discriminate individuals with periodontal diseases from PH (overall accuracy = 84%). Oral taxa were detected in high numbers in all stool samples.Conclusions: Individuals with periodontal diseases present a less diverse gut microbiome consistent with other systemic inflammatory diseases. High numbers of oral taxa related to periodontal destruction and inflammation were detected in the gut microbiome of individuals regardless of periodontal status.

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Section: Discussionmentioning

confidence: 99%

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Lourenςo

Spencer

Alm

et al. 2018

Journal of Oral Microbiology

117

109

View full text Add to dashboard Cite

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“…Although previous cohort studies indicated an association between lower microbial diversity and PPI use (11,12), we are the first to demonstrate a causal relationship between PPI use and microbiome disturbances. This is relevant because low microbial diversity is generally associated with poor health (28,29). Furthermore, low microbial diversity can cause defects in mucus formation and tight junction permeability, contributing to disturbances in ion reabsorption (30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI‐induced hypomagnesemia

et al. 2019

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Proton pump inhibitors (PPIs) are used by millions of patients for the treatment of stomach acid‐reflux diseases. Although PPIs are generally considered safe, about 13% of the users develop hypomagnesemia. Despite rising attention for this issue, the underlying mechanism is still unknown. Here, we examine whether the gut microbiome is involved in the development of PPI‐induced hypomagnesemia in wild‐type C57BL/6J mice. After 4 wk of treatment under normal or low dietary Mg2+ availability, omeprazole significantly reduced serum Mg2+ levels only in mice on a low‐Mg2+ diet without affecting the mRNA expression of colonic or renal Mg2+ transporters. Overall, 16S rRNA gene sequencing revealed a lower gut microbial diversity in omeprazole‐treated mice. Omeprazole induced a shift in microbial composition, which was associated with a 3‐ and 2‐fold increase in the abundance of Lactobacillus and Bifidobacterium, respectively. To examine the metabolic consequences of these microbial alterations, the colonic composition of organic acids was evaluated. Low dietary Mg2+ intake, independent of omeprazole treatment, resulted in a 10‐fold increase in formate levels. Together, these results imply that both omeprazole treatment and low dietary Mg2+ intake disturb the gut internal milieu and may pose a risk for the malabsorption of Mg2+ in the colon.—Gommers, L. M. M., Ederveen, T. H. A., van der Wijst, J., Overmars‐Bos, C., Kortman, G. A. M., Boekhorst, J., Bindels, R. J. M., de Baaij, J. H. F., Hoenderop, J. G. J. Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI‐induced hypomagnesemia. FASEB J. 33, 11235–11246 (2019). http://www.fasebj.org

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“…This is also the reason why dysbiosis is not a single condition and can be classified into different forms. Deficiency dysbiosis is a condition characterized by an overall reduction of beneficial bacterial species (such as lactobacilli and/or bifidobacteria), which can occur as a consequence of nonhealthy diets [60] or antibiotic therapies [61], and can be associated with food intolerances consequent to a deficiency in digestive enzymes (intolerance to milk or meat) [62]. Putrefactive dysbiosis, characterized by an increase in putrefactive bacteria (mainly Bacteroides ), generally results from a diet rich in fat and meat and poor in fibers [63], the metabolization of which can lead to products such as ammonia, amines, and phenols, which could be the cause of symptoms not limited to the gastrointestinal tract but that can also affect the entire body.…”

Section: Intestinal Dysbiosismentioning

confidence: 99%

Rebuilding the Gut Microbiota Ecosystem

Gagliardi

Totino

Cacciotti

et al. 2018

IJERPH

266

174

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A microbial ecosystem in which bacteria no longer live in a mutualistic association is called dysbiotic. Gut microbiota dysbiosis is a condition related with the pathogenesis of intestinal illnesses (irritable bowel syndrome, celiac disease, and inflammatory bowel disease) and extra-intestinal illnesses (obesity, metabolic disorder, cardiovascular syndrome, allergy, and asthma). Dysbiosis status has been related to various important pathologies, and many therapeutic strategies aimed at restoring the balance of the intestinal ecosystem have been implemented. These strategies include the administration of probiotics, prebiotics, and synbiotics; phage therapy; fecal transplantation; bacterial consortium transplantation; and a still poorly investigated approach based on predatory bacteria. This review discusses the various aspects of these strategies to counteract intestinal dysbiosis.

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Diet influence on the gut microbiota and dysbiosis related to nutritional disorders

Cited by 130 publications

References 61 publications

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI‐induced hypomagnesemia

Rebuilding the Gut Microbiota Ecosystem

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