Diet-Induced Weight Loss and Exercise Alone and in Combination Enhance the Expression of Adiponectin Receptors in Adipose Tissue and Skeletal Muscle, but Only Diet-Induced Weight Loss Enhanced Circulating Adiponectin

Christiansen, T.; Paulsen, Søren K.; Bruun, Jens Meldgaard; Ploug, Thorkil; Pedersen, Steen B.; Richelsen, Bjørn

doi:10.1210/jc.2008-2505

Cited by 92 publications

(94 citation statements)

References 36 publications

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“…Overall, they observed no significant effect of exercise on adiponectin levels, yet the exercise group appears to have decreased adiponectin levels by 7.2% (15). Several other studies which have observed increases in adiponectin levels have observed these changes with concomitant reductions in weight through a weight loss intervention arm and not through exercise (13,15,23). In our study, we did not observe between group differences for decreased mass.…”

Section: Discussioncontrasting

confidence: 63%

“…These results are counterintuitive, as lower levels of adiponectin are associated with increased risk for chronic diseases and a decrease was seen in the low-dose exercise group. Previous reports indicate there is variation with regards to the response of adiponectin levels to exercise, and a review by Simpson reports only 38% of RCTs demonstrate an exercise-induced increase in adiponectin levels (13)(14)(15)(23)(24)(25). Specific to this investigation, Friedenreich and colleagues reported that a yearlong aerobic exercise intervention of 225 min/wk (70%-85% of observed maximal heart rate) did not lead to any differences in adiponectin levels for 320 previously sedentary postmenopausal women (26).…”

Section: Discussionmentioning

confidence: 79%

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Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Sturgeon

DiGiovanni

Good

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Dysregulation of adipokines, such as adiponectin and leptin, is associated with a variety of chronic diseases, including cancer. Physical activity protects against breast cancer and one of the mechanisms which may underlie this association is exercise-induced changes in adipokine levels. The WISER Sister Trial was a three-armed randomized controlled trial in premenopausal women (n ¼ 137) with an elevated risk for breast cancer.Methods: A 5-menstrual-cycle-long dosed aerobic exercise intervention compared low-dose exercise (150 min/wk; n ¼ 44) or high-dose exercise (300 min/wk; n ¼ 48) with a control group asked to maintain usual activity levels (n ¼ 45). Exercise intensity progressed to and was maintained at 70% to 80% of age predicted heart rate max. Body composition and adipokine levels were measured at baseline and follow-up.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 79%

Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Sturgeon

DiGiovanni

Good

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Aerobic and resistance training produced more consistent increases in adiponectin if these programs also resulted in significant fat loss [69]. One study demonstrated that exercise with or without diet-induced weight loss increased adiponectin receptor expression, but only diet-induced weight loss produced an actual increase in serum adiponectin levels [95].…”

Section: Exercise Weight Loss Decreased Systemic Inflammation and Rmentioning

confidence: 99%

Obesity and Low Back Pain: Is There a Weight of Evidence to Support a Positive Relationship?

et al. 2013

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Obesity and low back pain (LBP) are responsible for significant morbidities and financial expenditure. Numerous studies have demonstrated a positive relationship between obesity and LBP, but a concurrent investigation of causality is often omitted. Spinal clinicians routinely prescribe exercise and weight loss for obese patients with LBP, despite a paucity of literature evaluating why obesity might cause LBP or how exercise and weight loss might be suitable treatments for LBP. Etiologies have tended to focus on the biomechanical effects of obesity that lead to excessive loading and degeneration of the lumbar spine. However, recent evidence suggests that systemic inflammation associated with obesity may also be an important contributor to LBP. In this article, the latest evidence investigating the relationship between obesity and LBP is reviewed, an overview of the impact of exercise and weight loss on LBP is provided, and proposed mechanisms connecting obesity, systemic inflammation, and LBP are outlined.

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“…AT samples were obtained by liposuction as previously described 26 from abdomen, subcutaneously (subcutaneous abdominal adipose tissue, SAAT) just below the level of the umbilicus in the midline, and from the gluteal region (subcutaneous gluteal adipose tissue, SGAT), between the greater trochanter and tuberositas ischii. This was performed under local anaesthesia with Lidocain 10 mg ml À1 without adrenalin.…”

Section: Investigationsmentioning

confidence: 99%

Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss

et al. 2011

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Context: Endocannabinoids (ECs) have a role in obesity by affecting appetite and through peripheral effects. Obesity is associated with a dysregulation of the endocannabinoid system (ECS). Objective: We aimed to determine the ECS in subcutaneous adipose tissue (AT) in obese subject and investigate the influence of diet-induced weight loss on this system. Design: The obese study participants underwent a 12 weeks diet regimen resulting in 10-12% weight loss. All study participants underwent fasting blood samples and AT biopsies from abdomen and gluteal region, the obese subjects both before and after weight loss. Setting and participants: A total of 21 healthy obese individuals (10 men/11 women, age 39.5 ± 1.6 years, body mass index (BMI): 37.5±0.8 kg m À2 ) and 21 age-and gender-matched lean subjects (BMI: 23.8±0.4 kg m À2 ) were studied. Main outcome measures: The activity of ECS in AT was determined by measuring arachidonoyl glycerol (2-AG) and N-arachidonoylethanolamine/anandamide in AT by mass spectrometry and gene expressions of enzymes and receptors involved in the ECS. Results: The EC, 2-AG was reduced in obese individuals in the gluteal AT depot (Po0.01). Moreover, 2-AG increased in both depots in the obese subjects following weight loss (Po0.05). The gene expression of the CB1 was either not affected by the obese state (in the gluteal AT depot) or reduced (in the abdominal depot, Po0.05) and significantly affected by weight loss. The expression of the degrading enzymes FAAH, FAAH2, MGL and MGL2 was differently affected by obesity, AT depot and weight loss. Conclusion: We found reduced levels of 2-AG in subcutaneous AT in obesity, which increased after weight loss. In abdominal AT, the low CB1 expression was normalised after weight loss, whereas in gluteal AT the CB1 expression was reduced after weight loss. These findings support the concept of a dysregulated ECS in AT in association with obesity.

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Diet-Induced Weight Loss and Exercise Alone and in Combination Enhance the Expression of Adiponectin Receptors in Adipose Tissue and Skeletal Muscle, but Only Diet-Induced Weight Loss Enhanced Circulating Adiponectin

Abstract: Exercise alone and in combination with a diet-induced weight loss enhance the mRNA expression of adiponectin receptors in AT and in SM but only a pronounced hypocaloric-induced weight-loss increases circulating adiponectin in obese subjects.

Cited by 92 publications

References 36 publications

Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Exercise-Induced Dose-Response Alterations in Adiponectin and Leptin Levels Are Dependent on Body Fat Changes in Women at Risk for Breast Cancer

Obesity and Low Back Pain: Is There a Weight of Evidence to Support a Positive Relationship?

Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss

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