Diet-induced obesity: rodent model for the study of obesity-related disorders

Rosini, Tiago Campos; Silva, Adelino Sánchez Ramos da; Moraes, Camila de

doi:10.1016/s0104-4230(12)70211-7

Cited by 12 publications

(4 citation statements)

References 29 publications

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“…Our analysis found maternal cafeteria‐style diets led to greater offspring body weight, whereas diet‐induced obesity was associated with increased offspring lipids and insulin concentrations. This might suggest different mechanisms for the programming of these metabolic phenotypes, potentially explained by differences in the caloric or nutritional makeups of these diets .…”

Section: Discussionmentioning

confidence: 99%

Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta‐regression analysis

et al. 2017

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SummaryAnimal models of maternal high fat diet (HFD) demonstrate perturbed offspring metabolism although the effects differ markedly between models. We assessed studies investigating metabolic parameters in the offspring of HFD fed mothers to identify factors explaining these inter‐study differences. A total of 171 papers were identified, which provided data from 6047 offspring. Data were extracted regarding body weight, adiposity, glucose homeostasis and lipidaemia. Information regarding the macronutrient content of diet, species, time point of exposure and gestational weight gain were collected and utilized in meta‐regression models to explore predictive factors. Publication bias was assessed using Egger's regression test.Maternal HFD exposure did not affect offspring birthweight but increased weaning weight, final bodyweight, adiposity, triglyceridaemia, cholesterolaemia and insulinaemia in both female and male offspring. Hyperglycaemia was found in female offspring only. Meta‐regression analysis identified lactational HFD exposure as a key moderator. The fat content of the diet did not correlate with any outcomes. There was evidence of significant publication bias for all outcomes except birthweight.Maternal HFD exposure was associated with perturbed metabolism in offspring but between studies was not accounted for by dietary constituents, species, strain or maternal gestational weight gain. Specific weaknesses in experimental design predispose many of the results to bias.

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Section: Discussionmentioning

confidence: 99%

Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta‐regression analysis

et al. 2017

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“…Data from the World Health Organization (WHO) indicate that by 2016 more than 1.9 billion adults, over 18 years old, were overweight and 650 million of those were obese (WHO, 2021). Although some authors suggest that the genetic factor contributes to the development of obesity, the most studies emphasize that the prevalence of this disease occurs due to environmental factors (Rosini et al, 2012). Therefore, excessive fat accumulation results from the energy imbalance obtained from the interaction between several factors, among the diets with high energy density (Feillet‐Coudray et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity

Kobi

Matias

Gasparini

et al. 2023

Physiological Reports

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“…HFD fed rats can act as a 'humanized' model for obesity and its related co-morbidities. 13,14 In the present study obesity and hypertension was induced in rats by feeding them on diet rich in fats. Systolic blood pressure increased significantly in rats fed on HFD as compared to the normal control group.…”

Section: Discussionmentioning

confidence: 80%

An experimental study to see the antihypertensive effects of gymnema sylvestre and acorus calamus in wistar rats and its comparison with amlodipine

Singh

Kumar

Sachan³

et al. 2017

Asian J Med Sci

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A B S T R A C T Background:The prevalence of obesity is increasing worldwide. Obesity has a direct correlation with insulin resistance and various cardiovascular diseases like hypertension, dyslipidaemia etc. Hypertension is considered as a major independent risk factor for coronary disease and stroke for all age, race & sex groups. Gymnema sylvestre and Acorus calamus are two well known herbs of traditional system of medicine effective in various diseases. Aims and Objectives: The present study was designed to explore the antihypertensive effects of Gymnema sylvestre (GS) and Acorus calamus (AC), individually as well as in combination, in wistar rats. Materials and Methods: Female wistar rats, weighing between 150-200 g, were included in the study. They were divided into eight groups with six rats in each group. High Fat diet (HFD) was used to induce hypertension in all the groups except group 1 which was fed with normal rodent diet. Drugs were given to the rats by oral feeding cannula. Results: Feeding rats with HFD for 4 weeks lead to significant increase in the mean systolic blood pressure. Both Gymnema sylvestre and Acorus calamus significantly reduced the systolic blood pressure. Combination of both these (Gymnema sylvestre 200mg/kg and Acorus calamus 200mg/kg) as well as Gymnema sylvestre (200mg/kg) individually has an effect comparable to Amlodipine. Individual drugs had no significant effect on heart rate while the combination of these two drugs significantly reduced the heart rate. Conclusions: The present study concludes that extracts of Gymnema sylvestre and Acorus calamus has a significant antihypertensive action in rodent model of hypertension. Combination is found superior to the individual drugs.

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Diet-induced obesity: rodent model for the study of obesity-related disorders

Cited by 12 publications

References 29 publications

Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta‐regression analysis

Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta‐regression analysis

High‐fat, high‐sucrose, and combined high‐fat/high‐sucrose diets effects in oxidative stress and inflammation in male rats under presence or absence of obesity

An experimental study to see the antihypertensive effects of gymnema sylvestre and acorus calamus in wistar rats and its comparison with amlodipine

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