Diet-induced obesity: rodent model for the study of obesity-related disorders

Rosini, Tiago Campos; Silva, Adelino Sánchez Ramos da; Moraes, Camila de

doi:10.1016/s2255-4823(12)70211-4

Cited by 41 publications

(30 citation statements)

References 29 publications

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“…HCDs are widely used to generate a valid rodent model for the metabolic syndrome with hyperlipaemia, hyperglycaemia and obesity . In this study, after 4 weeks of feeding, the plasma levels of TC, LDL‐C and glucose of HCF rats increased significantly ( P < 0.01) and the plasma HDL‐C level of HCF rats decreased significantly ( P < 0.01) (Table ).…”

Section: Resultsmentioning

confidence: 79%

Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high‐cholesterol diet

Zhou

Zhu

et al. 2013

J Sci Food Agric

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Section: Resultsmentioning

confidence: 79%

Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high‐cholesterol diet

Zhou

Zhu

et al. 2013

J Sci Food Agric

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“…[16] Some studies have demonstrated the ability of hypercaloric and hyperlipidemic diets administration to induce obesity and its metabolic disorders, especially in rodents. [17] Another animal model, such as zebra fish have been observed as an obesity model and this model is very appropriate to be developed as an obesity model through high-fat diet administration. [8][9][10][11][12][13][14][15][16][17][18] In the recent study, we use zebra fish (D. rerio) to explore the association between high-fat diet consumption, obesity, and metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…This result consistent with several researches which described obese zebra fish have developed by high-fat diet administration showed results of NAFLD. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Recent scientific reports showed that a high-fat diet is an ideal model to develop the obese condition and metabolic syndrome on zebrafish.…”

Section: Discussionmentioning

confidence: 99%

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Yuniarto¹

2019

IJGP

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Aim:Recently, the application of zebrafish as an experimental animal model has significantly increased, especially model for obesity. The aim of this research is to reveal the association between high-fat-diet-induced obesity and metabolic syndrome on the zebrafish model. Materials and Methods: Male zebra fish were used in this study. Acclimatization period was performed for 2 weeks when all fish received standard diet intake. Post acclimatization, zebra fish were divided into normal group and obese group. For 4 weeks, normal group received normal diet while the obese group received high-fat diet. Measurement parameters including body mass index (BMI) and blood biochemical parameters. Liver histopathological analysis was performed to observe nonalcoholic fatty liver disease (NAFLD). Results and Discussion: Zebra fish were divided into two groups such as normal group and obese group. Zebra fish were fed following the protocol for 4 weeks. Obese zebra fish showed increased of BMI and blood biochemical parameters compared to the normal group. In addition, excessive fat accumulation in obese zebrafish liver gave a contribution on the elevated NAFLD based on the histopathological study. Conclusion: It can be concluded that high-fat-diet-induced obesity on zebrafish has a strong association with metabolic syndrome.

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“…Hypercaloric diet has been used as a model of obesity induction in animals as its similarity with metabolic responses caused by obesity in humans [34]. It is reported that a hypercaloric diet induces significant body weight gain, adiposity, elevated serum triglycerides, and leptin [35].…”

Section: Discussionmentioning

confidence: 99%

Combination of Leptin Analog and Salbutamol: Treatment Approach for Obesity-Induced Asthma

Soni

Deshpande

2019

Asian J Pharm Clin Res

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Objective: The objective of the study was to investigate the effect of leptin analog and salbutamol in obese asthmatic mice. Methods: Obese asthmatic condition was induced by administration of hypercaloric diet for 8 weeks followed by ovalbumin-aluminum hydroxide. The animals were treated with leptin analog (0.4 mg/kg, i.p. for 14 days) and salbutamol (2 mg/kg, PO for 14 days). Biochemical parameters such as serum leptin, ghrelin, and tumor necrosis factor-α and physical parameters such as tidal volume and airflow rate were estimated to confirm the state of asthma and obesity, respectively. Results: Elevated serum leptin and ghrelin were associated with leptin resistance in obese asthmatic mice. It was found that a significant increase in serum leptin level with animal treated with leptin analog and salbutamol when compared to animals treated with leptin analog alone. The result of respiratory parameters and serum parameters also improved with the combination of leptin analog and salbutamol. From our study, we found that salbutamol potentiates the effect of leptin analog in obese asthmatic condition. Conclusion: Leptin analog and salbutamol are an alternative treatment approach to treat the obese asthmatic condition.

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Diet-induced obesity: rodent model for the study of obesity-related disorders

Cited by 41 publications

References 29 publications

Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high‐cholesterol diet

Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high‐cholesterol diet

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Combination of Leptin Analog and Salbutamol: Treatment Approach for Obesity-Induced Asthma

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