Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge

Amar, Salomon; Zhou, Qingde; Shaik‐Dasthagirisaheb, Yazdani B.; Leeman, Susan E.

doi:10.1073/pnas.0710335105

Cited by 224 publications

(253 citation statements)

References 34 publications

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“…There is clear evidence demonstrating more severe horizontal bone loss in murine models infected with P. gingivalis and other Gram‐negative bacteria in addition to this ligature placement (Samejima, Ebisu, & Okada, 1990; Amar, Zhou, Shaik‐Dasthagirisaheb, & Leeman, 2007). The combination of ligature placement and P. gingivalis infection also accelerated the destruction of periodontal tissue and bone resorption as compared to ligature placement without P. gingivalis in this study.…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis induced periodontitis exacerbates progression of non‐alcoholic steatohepatitis in rats

Kuraji

Fujita

et al. 2016

Clinical & Exp Dental Res

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Non‐alcoholic steatohepatitis (NASH) is a chronic liver disease that can develop into hepatocirrhosis and hepatic carcinoma. In recent years, epidemiological and animal studies have reported that Porphyromonas gingivalis (P. gingivalis), a known periodontopathic bacteria, is closely related to NASH. However, previous studies could not demonstrate a direct relationship between periodontitis, P. gingivalis infection, and NASH. The purpose of the present study was to examine the impact of P. gingivalis‐associated periodontitis on the onset and progression of NASH. Forty‐two male Wistar rats were used in this study. Rats were fed a high‐fat diet (HFD) for 12 weeks in order to induce fatty liver. At 4 weeks from the start of feeding, the animals were performed ligature placement around the maxillary first molar tooth in order to induce experimental periodontitis, and then a P. gingivalis slurry was applied around the ligature twice in a week for 8 weeks (HFD/Pg(+) group). Controls were given the slurry without P. gingivalis after ligature placement using the same protocol (HFD/Pg(−) group). Significant increases in alveolar bone resorption and inflammation in periodontal tissue around the molar tooth in the HFD/Pg(+) group were observed when compared with the HFD/Pg(−) group. Moreover, histological images showing NASH characterized by perivenular lipid deposition including big fatty drops, ballooning degeneration, and focal necrosis with inflammatory cells were confirmed in the liver of rats in the HFD/Pg(+) group. Significant increases in alanine aminotransaminase, aspartate aminotransferase, and C‐reactive protein levels were observed in the HFD/Pg(+) group. Furthermore, endotoxin levels in serum in the HFD/Pg(+) group were significantly higher than those in the HFD/Pg(−) group. The present study demonstrated that experimental periodontitis induced by P. gingivalis led to the progression of NASH in rats with fatty liver. Increased levels of endotoxin derived from P. gingivalis infection appear to play a considerable role in the progression of NASH.

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Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis induced periodontitis exacerbates progression of non‐alcoholic steatohepatitis in rats

Kuraji

Fujita

et al. 2016

Clinical & Exp Dental Res

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“…It has been suggested that fat cell size did not determine inflammation; thus, AT morphology is not involved in the release of inflammatory markers (Hoffstedt et al 2010). A recent study on bacterial challenge showed dysregulation in homeostatic networks counteracting inflammation as obesity develops (Amar et al 2007). The authors associated DIO with a form of immune paralysis.…”

Section: Inflammation and Ageing Inflammagingmentioning

confidence: 99%

Obesity and related consequences to ageing

Jura

Kozak

2016

AGE

331

203

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Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The increase in life expectancy is often accompanied with additional years of susceptibility to chronic ill health associated with obesity in the elderly. Both obesity and ageing are conditions leading to serious health problems and increased risk for disease and death. Ageing is associated with an increase in abdominal obesity, a major contributor to insulin resistance and the metabolic syndrome. Obesity in the elderly is thus a serious concern and comprehension of the key mechanisms of ageing and age-related diseases has become a necessary matter. Here, we aimed to identify similarities underlying mechanisms related to both obesity and ageing. We bring together evidence that age-related changes in body fat distribution and metabolism might be key factors of a vicious cycle that can accelerate the ageing process and onset of age-related diseases.

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“…First, immune function is affected by host nutrition, which may greatly affect the outcome of infection (Lazzaro and Little, 2009;Schmid-Hempel, 2011). Host nutrition influences both constitutive and inducible immune function, with consequences for morbidity and mortality (Cunningham-Rundles et al, 2005;Klasing, 2007) (Adams and Hewison, 2008;Amar et al, 2007;Calder, 2006;Cohen et al, 2008;Kelley and Bendich, 1996;Klasing, 2007;Kolb, 1997;Kristan, 2007;Samartin and Chandra, 2000;Sorci and Faivre, 2009). Second, nutrition-based interactions are one of the major sources of microbial benefits to animals (Bäckhed et al, 2005;Douglas, 2010;Hooper et al, 2002;Kau et al, 2011;Topping and Clifton, 2001).…”

Section: Introductionmentioning

confidence: 99%