Diet-induced metabolic acidosis

Adeva, María M.; Souto, Gema

doi:10.1016/j.clnu.2011.03.008

Cited by 248 publications

(264 citation statements)

References 54 publications

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“…It has recently been suggested that acid/base imbalance may play an important role in some cardiometabolic abnormalities [3][4][5]. Markers of diet-induced metabolic acidosis have been associated with insulin resistance, but only in crosssectional studies [6][7][8], preventing any conclusions in terms of causality.…”

Section: Introductionmentioning

confidence: 99%

“…A recent review suggested that imbalances in acid/base homeostasis may play an important role in some cardiometabolic abnormalities [4]: an acidogenic diet may cause chronic metabolic acidosis over time, which may then lead to insulin resistance and the metabolic syndrome. This mechanism was supported by cross-sectional studies showing that a high dietary acid load was associated with insulin resistance [6][7][8].…”

Section: Biological Mechanismsmentioning

confidence: 99%

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Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study

et al. 2013

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Aims/hypothesis The objective of this study was to evaluate the prospective relationship between dietary acid load, assessed with both the potential renal acid load (PRAL) and the net endogenous acid production (NEAP) scores, and type 2 diabetes risk. Methods A total of 66,485 women from the E3N-EPIC cohort were followed for incident diabetes over 14 years. PRAL and NEAP scores were derived from nutrient intakes. HRs for type 2 diabetes risk across quartiles of the baseline PRAL and NEAP scores were estimated with multivariate Cox regression models. Results During follow-up, 1,372 cases of incident type 2 diabetes were validated. In the overall population, the highest PRAL quartile, reflecting a greater acid-forming potential, was associated with a significant increase in type 2 diabetes risk, compared with the first quartile (HR 1.56, 95% CI 1.29, 1.90). The association was stronger among women with BMI <25 kg/m 2 (HR 1.96, 95% CI 1.43, 2.69) than in overweight women (HR 1.28, 95% CI 1.00, 1.64); statistically significant trends in risk across quartiles were observed in both groups ( p trend <0.0001 and p trend =0.03, respectively). The NEAP score provided similar findings. Conclusions/interpretationWe have demonstrated for the first time in a large prospective study that dietary acid load was positively associated with type 2 diabetes risk, independently of other known risk factors for diabetes. Our results need to be validated in other populations, and may lead to promotion of diets with a low acid load for the prevention of diabetes. Further research is required on the underlying mechanisms.

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Section: Introductionmentioning

confidence: 99%

Section: Biological Mechanismsmentioning

confidence: 99%

Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study

et al. 2013

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“…Although kidney transplantation is the preferred treatment for patients with ESRD, successful transplantation is still associated with substantially elevated morbidity and mortality (2,3). Many renal transplant recipients (RTRs) have metabolic acidosis (4,5), which may adversely affect cardiometabolic processes, including BP and insulin resistance, as well as proper functioning of multiple tissues (4,6,7). Therefore, it is important to identify modifiable determinants of metabolic acidosis that might help improve acid-base homeostasis in RTRs.…”

Section: Introductionmentioning

confidence: 99%

Dietary Acid Load and Metabolic Acidosis in Renal Transplant Recipients

Berg

Engberink

Brink

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Acidosis is prevalent among renal transplant recipients (RTRs) and adversely affects cardiometabolic processes. Factors contributing to acidosis are graft dysfunction and immunosuppressive drugs. Little is known about the potential influence of diet on acidosis in RTRs. This study examined the association of metabolic acid load with acidosis and with cardiovascular risk factors in RTRs and aimed to identify dietary factors associated with acidosis.Design, participants, setting, & measurements 707 RTRs were included. Metabolic acid load was assessed by measuring 24-hour urinary net acid excretion (NAE; i.e., titratable acid + ammonium 2 bicarbonate). Acidosis was defined as serum [HCO 3 2 ] , 24 mmol/L. BP and insulin resistance, reflected by hemoglobin A1c, were among cardiovascular risk factors. Diet was assessed with food-frequency questionnaires. Linear regression analysis was applied to investigate association between NAE and acidosis and between dietary factors and acidosis.Results Mean age 6 SD was 53613 years; 57% of patients were male. Acidosis was present in 31% of RTRs. NAE was associated with acidosis (serum HCO 3 2 : b=20.61; serum pH: b=20.010; both P,0.001). Patients with high intake of animal protein (i.e., from meat, cheese, and fish) and low intake of fruits and vegetables had significantly lower serum HCO 3 2 and serum pH. No associations were observed between NAE and cardiovascular risk factors, such as hypertension and insulin resistance.Conclusions In addition to conventional factors contributing to acidosis, diet might influence acid-base homeostasis in RTRs. Higher intake of fruits and vegetables and lower animal protein intake is associated with less acidosis in RTRs.

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“…Although acidosis decreases renal excretion of citrate and increases its reabsorption, the opposite is true in alkalosis [32]. A Western-type diet that includes decreased consumption of fruits and vegetables and increased consumption of animal products causes metabolic acidosis, resulting in lower urine pH and hypocitraturia [33]. Hypokalemia also lowers urine pH, and low potassium intake decreases urine potassium and citrate in hypokalemia and increases urinary excretion of calcium [32,34].…”

Section: Nutritionmentioning

confidence: 99%

Metaphylaxis in Pediatric Urinary Stone Disease

Kaygısız¹

2017

Updates and Advances in Nephrolithiasis - Pathophysiology, Genetics, and Treatment Modalities

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Diet-induced metabolic acidosis

Cited by 248 publications

References 54 publications

Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study

Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study

Dietary Acid Load and Metabolic Acidosis in Renal Transplant Recipients

Metaphylaxis in Pediatric Urinary Stone Disease

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