Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys

Golub, Mari S.; Hogrefe, Casey E.; Tarantal, Alice F.; Germann, Stacey L.; Beard, John L.; Georgieff, Michael; Calatroni, Agustin; Lozoff, Betsy

doi:10.1093/ajcn.83.3.647

Cited by 44 publications

(53 citation statements)

References 41 publications

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“…Diet group effects, first observed at birth [26], were also seen at one month (F = 3.60, p = .04) and four months (F = 3.83, p = .03). Prenatally deprived group had smaller head width than controls (see Table 3 for individual group comparisons).…”

Section: Growth and Healthmentioning

confidence: 80%

“…These infants were offspring of dams fed iron-regulated purified diets during pregnancy, either 10 μg Fe/g (iron deprived) or 100 μg Fe/g (iron adequate) [27]. Iron status of the dams during pregnancy and of the infants at birth have been previously reported [26]. Briefly, dams fed low iron diets during pregnancy developed IDA in the third trimester and the infants were born with compromised iron and hematological status.…”

Section: Subjectsmentioning

confidence: 99%

“…A complete blood count (CBC) and supplemental iron status measures (transferrin receptor (TfR), serum ferritin, serum iron, zinc protoporphyrin (ZPP)) were conducted as described previously [26]. The CBC included RDW (red blood cell distribution width).…”

Section: Hematology and Iron Status Measuresmentioning

confidence: 99%

“…We recently demonstrated third trimester iron deficiency anemia in rhesus monkey dams fed low iron diets beginning in the first trimester [26]. In rhesus monkey colonies, a high prevalence of anemia has been detected late in infancy and the juvenile period, as is the case in humans [1,7,36].…”

Section: Introductionmentioning

confidence: 99%

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Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Golub

Hogrefe

Germann

et al. 2006

Neurotoxicology and Teratology

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Human studies have shown that iron deficiency and iron deficiency anemia in infants are associated with behavioral impairment, but the periods of brain development most susceptible to iron deficiency have not been established. In the present study, rhesus monkeys were deprived of iron by dietary iron restriction during prenatal (n = 14, 10 μg Fe/g diet) or early postnatal (n = 12, 1.5 mg Fe/L formula) brain development and compared to controls (n = 12, 100 μg Fe/g diet, 12 mg Fe/L formula) in behavioral evaluations conducted during the first four months of life in the nonhuman primate nursery. Iron deficiency anemia was detected in the pregnant dams in the third trimester and compromised iron status was seen in the prenatally iron-deprived infants at birth, but no iron deficiency was seen in either the prenatally or postnatally iron-deprived infants during the period of behavioral evaluation. Neither prenatal nor postnatal iron deprivation led to significant delays in growth, or gross or fine motor development. Prenatally deprived infants demonstrated a 20% reduced spontaneous activity level, lower inhibitory response to novel environments, and more changes from one behavior to another in weekly observation sessions. Postnatally deprived infants demonstrated poorer performance of an object concept task, and greater emotionality relative to controls. This study indicates that different syndromes of behavioral effects are associated with prenatal and postnatal iron deprivation in rhesus monkey infants and that these effects can occur in the absence of concurrent iron deficiency as reflected in hematological measures.

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Section: Growth and Healthmentioning

confidence: 80%

Section: Subjectsmentioning

confidence: 99%

Section: Hematology and Iron Status Measuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Golub

Hogrefe

Germann

et al. 2006

Neurotoxicology and Teratology

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show abstract

“…Several studies showed significantly lower cord hemoglobin levels in the infants of severely anemic women compared with infants born to iron-sufficient mothers. [109][110][111][112] Likewise, diet-induced maternal anemia in rhesus monkeys caused a significant reduction in hemoglobin, mean corpuscular volume, and bone marrow colony-forming units in the newborns, 113 suggesting a limited capacity of the placenta to support fetal erythroid needs in the face of severe maternal deficiency.…”

Section: Regulation Of Iron Transport Across the Placentamentioning

confidence: 99%

The placenta: the forgotten essential organ of iron transport

Cao

Fleming

2016

Nutr Rev

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Developmental plasticity of red blood cell homeostasis

et al. 2014

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Most human physiologic set points like body temperature are tightly regulated and show little variation between healthy individuals. Red blood cell (RBC) characteristics such as hematocrit (HCT) and mean cell volume (MCV) are stable within individuals but can vary by 20% from one healthy person to the next. The mechanisms for the majority of this inter-individual variation are unknown and do not appear to involve common genetic variation. Here we show that environmental conditions present during development, namely in utero iron availability, can exert long-term influence on a set point related to the RBC life cycle. In a controlled study of rhesus monkeys and a retrospective study of humans, we use a mathematical model of in vivo RBC population dynamics to show that in utero iron deficiency is associated with a lowered threshold for RBC clearance and turnover. This in utero effect is plastic, persisting at least two years after birth and after the cessation of iron deficiency. Our study reports a rare instance of developmental plasticity in the human hematologic systems and also shows how mathematical modeling can be used to identify cellular mechanisms involved in the adaptive control of homeostatic set points.

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Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeys

Abstract: These data indicate that an inadequate intake of iron from the diet during pregnancy in rhesus monkeys can lead to compromised hematologic status of the neonate without indications of growth retardation or impaired neurologic function at birth.

Cited by 44 publications

References 41 publications

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys

The placenta: the forgotten essential organ of iron transport

Developmental plasticity of red blood cell homeostasis

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