Diet-Induced Changes in Trough Theophylline Concentrations in an Elderly Asthmatic Patient

Juan, David; Shin, Sang‐Goo; Holmes, Thomas H.; Hughes, Richard L.

doi:10.1378/chest.93.5.1113

Cited by 1 publication

(1 citation statement)

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“…The results presented above are in contrast to the case study recently reported in an elderly subject with chronic obstructive pulmonary disease maintained on a low calorie and low protein diet for three months after initially being studied on a 1100 kcal/day/35 g protein/day diet (Juan et al 1988). It was reported that the prolonged exposure to the hypocaloric and low protein diet led to a 49% decrease in theophylline clearance with a concomitant increase in half-life from 8.4 to 23.2 hr.…”

Section: Discussioncontrasting

confidence: 99%

The Effects of Age and Dietary Protein Restriction on the Pharmacokinetics of Theophylline in the Rat

Jung

Nanavaty

1990

Pharmacology & Toxicology

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The influence of dietary protein levels on theophylline kinetics was examined in male Fischer 344 virgin rats of 2, 14 and 20 months of age fed for four weeks on a 23% (control) or 5% (low) protein diet ad libitum. Protein deficiency led to a significant decrease in body weight gain for the 2 month old rats (10.9% versus 26.5%). In addition, decreases in total body weight of 7.5% and 15.3% were seen for the 14 and 20 month old rats, respectively, on a low protein diet. Total proteins and albumin levels in plasma were not significantly affected by age or dietary protein levels. After intravenous administration of 10 mg/kg aminophylline, the average mean residence time (MRT) was significantly longer in 20 month old rats as compared to the younger rats, while 14 month old rats had a greater elimination rate constant than the 2 and 20 month old rats. There were significant reductions in the mean steady-state apparent volume of distribution (Vss) in the 2 and 14 month old rats on a low protein diet of 31% and 18%, respectively, while there was no difference between the diets in 20 month old rats. In addition, the Vss decreased from 0.71 L/kg to 0.57 L/kg in the 2 and 20 month old rats, respectively, on a normal protein diet. Dietary protein deficiency led to a significant reduction of total body clearance from approximately 73 to 45 ml/hr/kg in the 2 and 14 month old rats.2+p

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Section: Discussioncontrasting

confidence: 99%