Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats

Paul, Heather A.; Bomhof, Marc R.; Vogel, Hans J.; Reimer, Raylene A.

doi:10.1038/srep20683

Cited by 153 publications

(165 citation statements)

References 62 publications

(81 reference statements)

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…Independent studies have implicated certain bacterial species, including E. coli, as a major modifying factor of this phenotype in the mouse, 81 though it is uncertain if E. coli has a similar impact on infant adiposity and growth trajectories in humans. Intriguingly, mitigating the effects of a high-fat diet on the maternal gut microbiota with a prebiotic supplement appears to attenuate the impact of maternal diet on the offspring's propensity for adiposity, 82 indicating that additional dietary manipulations could be useful to offset the long standing impact of a sustained highfat diet. However, the development of obesity is an incredibly complex pathophysiological process that may be first programmed in fetal life, but is likely sustained in postnatal life by continued environmental exposure to high-density dietary intake or aberrant microbiota.…”

Section: Impact On Offspring Health and Diseasementioning

confidence: 99%

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

et al. 2016

View full text Add to dashboard Cite

Evidence supporting the Developmental Origins of Health and Disease Hypothesis indicates that maternal nutrition in pregnancy has a significant impact on offspring disease risk later in life, likely by modulating developmental processes in utero. Gut microbiota have recently been explored as a potential mediating factor, as dietary components strongly influence microbiota abundance, function and its impact on host physiology. A growing body of evidence has additionally indicated that the intrauterine environment is not sterile as once presumed, indicating that maternal-fetal transmission of microbiota may occur during pregnancy. In this article, we will review the body of literature that supports this emerging hypothesis, as well as highlight the work in relevant animal models demonstrating associations with maternal gestational nutrition and the offspring gut microbiome that may influence offspring physiology and susceptibility to disease.

show abstract

Section: Impact On Offspring Health and Diseasementioning

confidence: 99%

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A study in rats suggested that oligo fructose consumption might normalize the metabolomic signature of insulin resistance in obese rats and reduce obesity in offspring 73 . The ability to enhance secretion of satiety hormones peptide YY and glucagon like peptide 1 might be an associated attribute of prebiotic intervention and related SCFA production [74][75][76] .…”

Section: Prebiotic Utilization and Host Healthmentioning

confidence: 99%

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson

Hutkins

Sanders³

et al. 2017

Nat Rev Gastroenterol Hepatol

Self Cite

3,475

2,428

View full text Add to dashboard Cite

In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food. The requirement for selective microbiota-mediated mechanisms was retained. Beneficial health effects must be documented for a substance to be considered a prebiotic. The consensus definition applies also to prebiotics for use by animals, in which microbiota-focused strategies to maintain health and prevent disease is as relevant as for humans. Ultimately, the goal of this Consensus Statement is to engender appropriate use of the term 'prebiotic' by relevant stakeholders so that consistency and clarity can be achieved in research reports, product marketing and regulatory oversight of the category. To this end, we have reviewed several aspects of prebiotic science including its development, health benefits and legislation

show abstract

“…Alterations in maternal microbiota composition, associated with both diet and obesity status, have been widely reported [15-18]. Disruption of the mother’s gut microbiota can influence early pioneering bacteria in the newborn and may be a prime candidate for intergenerational transmission of metabolic disease risk given the considerable influence of these microbes on infant growth [19, 20], immune system development [21-23], and even neural development [24, 25].…”

Section: Introductionmentioning

confidence: 99%

Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition

Zhang¹,

Dong²,

Sun³

et al. 2019

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: Paternal exposure to adverse environmental conditions can act on offspring’s phenotype and influence offspring’s later life disease risk. Our study was designed to examine the effect of feeding male rats before mating a high-fat, high-sucrose and high-salt diet (HFSSD) over two generations (F0 and F1) on their offspring’s (F2) liver function and gut microbiome composition. Methods: Male F0 rats and male F1 rats were fed either control diet or HFSSD before mating. Liver function of F2 offspring was investigated, and their gut microbiome composition was analyzed by 16S rRNA gene sequencing in the F2 offspring of rats whose fathers and grandfathers were fed with control diet (CD) (F0CD+F1CD-F2 group) or HFSSD prior to mating (F0HD+F1HD-F2 group). Results: F2 offspring had higher serum aspartate aminotransferase activity (female, p < 0.05 and male, p < 0.01 respectively) compared with control. Shannon indexes of gut microbiota indicated a significantly higher diversity in the female F0HD+F1HD-F2 as compared to F0CD+F1CD-F2 female offspring (p < 0.01). The dominant phyla of all the groups were Bacteroidetes, Firmicutes and Proteobacteria. There were significant differences in gut bacterial community composition at phyla and genus level between the F0CD+F1CD-F2 and F0HD+F1HD-F2. Furthermore, the variation in the relative abundance (percentage) of bacterial genus in the F2 offspring was associated with liver function alterations induced by a paternal pre-conceptional unhealthy diet. Male F0HD+F1HD-F2 offspring had higher serum cholesterol, high density lipoproteins as well as low density lipoproteins concentrations compared to the corresponding male control rats. Conclusion: Taken together, our findings suggested that a paternal pre-conceptional unhealthy diet predisposes the offspring to mild liver function alterations and alterations of gut microbiota in later life. Effects on lipids were sex-specific and only seen in male offspring.

show abstract

Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats

Cited by 153 publications

References 62 publications

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition

Contact Info

Product

Resources

About