Diet in a global cohort of adults with HIV at low-to-moderate traditional cardiovascular disease risk

Fitch, Kathleen V.; McCallum, Sara; Erlandson, Kristine M.; Overton, Edgar Turner; Zanni, Markella V.; Fichtenbaum, Carl J.; Aberg, Judith A.; Fulda, Evelynne S; Kileel, Emma M.; Moran, Laura; Bloomfield, Gerald S.; Novak, Richard M.; Pérez-Frontera, Sigrid; Abrams-Downey, Alexandra; Pierone, Gerald; Kumarasamy, Nagalingeswaran; Ruxrungtham, Kiat; Mngqibisa, Rosie; Douglas, Pamela S.; Ribaudo, Heather J.; Grinspoon, Steven

doi:10.1097/qad.0000000000003344

Cited by 4 publications

(2 citation statements)

References 31 publications

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“… 41 Patients with higher ASCVD risk were more likely to be older; men; smokers; hypertensive; of African ancestry; and have higher triglyceride and glucose concentrations and lower HDL‐C, CD4 count, and estimated glomerular filtration rate. 42 There were no differences in physical activity, body mass index, and LDL‐C concentration at the time of enrollment among patients in different ASCVD risk tertiles.…”

Section: Resultsmentioning

confidence: 86%

Polygenic Scores and Preclinical Cardiovascular Disease in Individuals With HIV: Insights From the REPRIEVE Trial

Zou,

Ruan,

Truong

et al. 2024

JAHA

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Background Coronary artery disease (CAD) is a leading cause of death among the 38.4 million people with HIV globally. The extent to which cardiovascular polygenic risk scores (PRSs) derived in non‐HIV populations generalize to people with HIV is not well understood. Methods and Results PRSs for CAD (GPS Mult ) and lipid traits were calculated in a global cohort of people with HIV treated with antiretroviral therapy with low‐to‐moderate atherosclerotic cardiovascular disease risk enrolled in REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV). The PRSs were associated with baseline lipid traits in 4495 genotyped participants, and with subclinical CAD in a subset of 662 who underwent coronary computed tomography angiography. Among participants who underwent coronary computed tomography angiography (mean age, 50.9 [SD, 5.8] years; 16.1% women; 41.8% African, 57.3% European, 1.1% Asian), GPS Mult was associated with plaque presence with odds ratio (OR) per SD in GPS Mult of 1.42 (95% CI, 1.20–1.68; P =3.8×10 −5 ), stenosis >50% (OR, 2.39 [95% CI, 1.48–3.85]; P =3.4×10 −4 ), and noncalcified/vulnerable plaque (OR, 1.45 [95% CI, 1.23–1.72]; P =9.6×10 −6 ). Effects were consistent in subgroups of age, sex, 10‐year atherosclerotic cardiovascular disease risk, ancestry, and CD4 count. Adding GPS Mult to established risk factors increased the C‐statistic for predicting plaque presence from 0.718 to 0.734 ( P =0.02). Furthermore, a PRS for low‐density lipoprotein cholesterol was associated with plaque presence with OR of 1.21 (95% CI, 1.01–1.44; P =0.04), and partially calcified plaque with OR of 1.21 (95% CI, 1.01–1.45; P =0.04) per SD. Conclusions Among people with HIV treated with antiretroviral therapy without documented atherosclerotic cardiovascular disease and at low‐to‐moderate calculated risk in REPRIEVE, an externally developed CAD PRS was predictive of subclinical atherosclerosis. PRS for low‐density lipoprotein cholesterol was also associated with subclinical atherosclerosis, supporting a role for low‐density lipoprotein cholesterol in HIV‐associated CAD. Registration URL: https://www.reprievetrial.org ; Unique identifier: NCT02344290.

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Section: Resultsmentioning

confidence: 86%

Polygenic Scores and Preclinical Cardiovascular Disease in Individuals With HIV: Insights From the REPRIEVE Trial

Zou,

Ruan,

Truong

et al. 2024

JAHA

Self Cite

View full text Add to dashboard Cite

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“… 76 The REPRIEVE study of cardiovascular health, for example, found that more than 60% had optimal diet in South Asia, whereas only 6% did in sub-Saharan Africa. 77 The literature on interventions to address food insecurity is mixed. 78 Regarding housing, as of 2016, it was estimated that greater then 10% of PWH of all ages had unmet housing needs.…”

Section: Components Of Carementioning

confidence: 99%

Treatment Regimens and Care Models for Older Patients Living with HIV: Are We Doing Enough?

Frey¹,

Johnston²,

Siegler³

2023

HIV

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With improved access to antiretroviral therapy throughout the world, people are aging with HIV, and a large portion of the global population of people with HIV (PWH) is now age 50 or older. Older PWH experience more comorbidities, aging-related syndromes, mental health challenges, and difficulties accessing fundamental needs than the population of older adults without HIV. As a result, ensuring that older PWH are receiving comprehensive healthcare can often be overwhelming for both PWH and the providers. Although there is a growing literature addressing the needs of this population, gaps remain in care delivery and research. In this paper, we suggest seven key components to any healthcare program designed to address the needs of older people with HIV: management of HIV, comorbidity screening and treatment, primary care coordination and planning, attention to aging related-syndromes, optimization of functional status, support of behavioral health, and improved access to basic needs and services. We review many of the difficulties and controversies related to the implementation of these components, which include the absence of screening guidelines for this population and the challenges of care integration, and we suggest key next steps.

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“God Meant I Should Be Free”: Historical Black Women Teachers and the Womanist Theo-Ethical Imperative of Abolition

Neal-Stanley

2024

Educational Studies

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Diet in a global cohort of adults with HIV at low-to-moderate traditional cardiovascular disease risk

Cited by 4 publications

References 31 publications

Polygenic Scores and Preclinical Cardiovascular Disease in Individuals With HIV: Insights From the REPRIEVE Trial

Polygenic Scores and Preclinical Cardiovascular Disease in Individuals With HIV: Insights From the REPRIEVE Trial

Treatment Regimens and Care Models for Older Patients Living with HIV: Are We Doing Enough?

“God Meant I Should Be Free”: Historical Black Women Teachers and the Womanist Theo-Ethical Imperative of Abolition

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