Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2 (TFF2) as an Illustration: Metabolic Implications and Potential Applications

Ghanemi, Abdelaziz; Yoshioka, Mayumi; St‐Amand, Jonny

doi:10.3390/biom11121830

Cited by 7 publications

(7 citation statements)

References 206 publications

(236 reference statements)

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“…It is worth mentioning that diet not only contributes to obesity development via increased energy intake, but also via its indirect effects [ 42 ]. Indeed, various food elements (vitamins, antioxidants, etc.)…”

Section: Modern Health Challenges and Obesitymentioning

confidence: 99%

In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues

2022

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Obesity represents a heavy burden for modern healthcare. The main challenge facing obesity research progress is the unknown underlying pathways, which limits our understanding of the pathogenesis and developing therapies. Obesity induces specific biochemical environments that impact the different cells and tissues. In this piece of writing, we suggest mimicking obesity-induced in vivo biochemical environments including pH, lipids, hormones, cytokines, and glucose within an in vitro environment. The concept is to reproduce such biochemical environments and use them to treat the tissue cultures, explant cultures, and cell cultures of different biological organs. This will allow us to clarify how the obesity-induced biochemistry impacts such biological entities. It would also be important to try different environments, in terms of the compositions and concentrations of the constitutive elements, in order to establish links between the effects (impaired regeneration, cellular inflammation, etc.) and the factors constituting the environment (hormones, cytokines, etc.) as well as to reveal dose-dependent effects. We believe that such approaches will allow us to elucidate obesity mechanisms, optimize animal models, and develop therapies as well as novel tissue engineering applications.

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Section: Modern Health Challenges and Obesitymentioning

confidence: 99%

In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues

2022

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“…Therefore, the solution is to reverse this pattern by reducing food intake and/or increasing energy expenditure. Within this context, the most used approaches to manage obesity are both diet control and physical activity [ 41 , 42 , 43 ]. Dietary intervention is fundamental and essential as the first-line treatment for obese patients, and the main rule of every dietary modification is calorie restriction and consequent weight loss (e.g., [ 44 ]).…”

Section: Obesity As a Health Problemmentioning

confidence: 99%

“…In some cases, pharmacotherapies are also used against obesity [ 45 , 46 ]. In addition, since the diet is not only about caloric density, but also about selected properties of the nutritive elements [ 42 ], some additional measures have also been reported in the literature as beneficial for obesity, such as the consumption of tea, coffee [ 47 , 48 ] and curry which include polyphenols [ 49 ]. However, when the various methods of managing obesity fail, bariatric surgery or liposuction could represent the last options when obesity has reached a certain level.…”

Section: Obesity As a Health Problemmentioning

confidence: 99%

Tricking the Brain with Leptin to Limit Post Liposuction and Post Bariatric Surgery Weight Regain?

2022

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Obesity represents a medical challenge for modern therapists. The main difficulty is that once obesity is established, it is hard to reverse. It is believed that once an increased body weight/adiposity content is reached it becomes the “reference” that energy mechanisms adjust towards keeping. Thus, following a weight loss, such as following liposuction/bariatric surgery, the metabolic balance would target this “reference” that represents the previously reached body weight/adiposity content. On the other hand, medical procedures of liposuction and bariatric surgery reduce the level of the adipocytes-produced hormone leptin. This leptin level reduction leads to an increase in food intake and a decrease in energy expenditure. Therefore, the reduced leptin would be among the signals received by the brain to trigger weight regain via processes aiming to re-establish the pre-liposuction/pre-bariatric surgery body weight or adiposity content. We suggest administering leptin so that the brain does not detect the post- liposuction/post-bariatric surgery weight loss; thus, limiting the signals toward weight regain, leading to a better weight control.

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“…Obesity is a serious worldwide health problem as it can lead to metabolic syndrome and death. It carries a significant risk of morbidity, leading to increased mortality [1]- [5]. Overweight is a term that includes both overweight and obesity [6]- [10].…”

Section: Introductionmentioning

confidence: 99%

Body weight training intervention towards weight loss of adolescent with obesity problem during COVID-19 pandemic

Anggraini

Ratnawati

Ritanti

et al. 2023

IJPHS

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The COVID-19 pandemic has brought attention to the rising issue of sedentary behavior, which can lead to obesity. Obesity affects individuals of all ages, including children, adults, and the elderly. Obesity can have negative effects on adolescent body image. Several interventions, such as body weight training, have been shown to help obese adolescents lose weight. This paper proposes an investigation into the effectiveness of body weight training interventions as implemented by community nurses for weight loss in obese adolescents. The intervention involved three sessions per week over the course of four weeks and was administered to several obese adolescents. The results indicated that there was a weight loss of 3.7 kg for the first participant and 3.8 kg for the second participant over the four-week period. Statistical analysis using a paired t-test showed a p-value less than 0.005, indicating a significant effect of the body weight training intervention on weight loss in obese adolescents. It is hoped that community nurses can utilize body weight training as a useful intervention in helping obese adolescents achieve a healthy weight.

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Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2 (TFF2) as an Illustration: Metabolic Implications and Potential Applications

Cited by 7 publications

References 206 publications

In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues

In Vitro Mimicking of Obesity-Induced Biochemical Environment to Study Obesity Impacts on Cells and Tissues

Tricking the Brain with Leptin to Limit Post Liposuction and Post Bariatric Surgery Weight Regain?

Body weight training intervention towards weight loss of adolescent with obesity problem during COVID-19 pandemic

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