Diet formulated with black seed flour activates regulatory androgenic enzymes and neuroendocrine hormones in leachate-exposed reproductive damage of rat testes

Akintunde, J. K.; Irondi, A.E.; Ajani, Emmanuel Oladipo; Olayemi, T.V.

doi:10.1016/j.jnim.2019.02.003

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…The restoration of functional integrity of pituitary–gonadal axis by dietary inclusion of NSS in MSG challenged rats is similar to that found in mice exposed to carbendazim 54 . This outcome may be attributed to the ability of NSS to increase the testicular steroidogenic enzymes activities 55 . Thymoquinone diminishes the apoptotic changes in Leydig cells as reported in previous investigation 22 .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats

Abd-Elkareem

El-Rahman

Khalil

et al. 2021

Sci Rep

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Monosodium glutamate (MSG) is one of the most widely spread food additives that might cause male infertility. However, Nigellasativa L. seeds (NSS) could provide a solution. This study was designed to investigate the potential effects of NSS on rats ingesting MSG. To achieve this aim, adult male albino rats were randomly equally assigned into three groups for 21 days: control group received no treatment, MSG group received MSG as 30 g/kg feed, and MSG + NSS group received MSG as 30 g/kg and NSS as 30 g/kg feed. Testis histomorphometry showed marked deterioration by MSG as atrophic seminiferous tubules with degeneration of their lining cells, damaged Leydig cells and decreased germ cells number. Periodic Acid Schiff stain indicated irregular interrupted basement membranes. Glutathione reductase, superoxide dismutase 2 (SOD2), and caspase-3 immuno-expressions increased in testicular cells. Testosterone levels were significantly decreased in MSG challenged rats along with significant increase in luteinizing hormone levels, whereas NSS normalized this hormonal profile. MSG exposure also caused significantly increased lipid peroxides (LPO), glutathione-S-transferase, and total antioxidant capacity (TAC) whereas nitric oxide and SOD2 were significantly decreased. NSS succeeded in rebalance LPO and TAC and ameliorated the histoarchitectural disturbances. NSS mitigated MSG-induced testicular impairment by its antioxidant and cytoprotective activities.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats

Abd-Elkareem

El-Rahman

Khalil

et al. 2021

Sci Rep

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“…More so, plant seeds are important component of human diets and are often regarded as medicines and good foods (Kuku et al, 2014). Some studies have used dietary factors of plant origin to modulate oxidative stress in the hypothalamus pituitary‐testicular axis of rats (Akintunde et al, 2019; Ekaluo et al, 2016). Fluted pumpkin, commonly called Ugu by natives of the South‐eastern Nigeria, is an edible greenish leafy vegetable indigenous to West Africa.…”

Section: Introductionmentioning

confidence: 99%

Fluted pumpkin seeds protect the spermatogenesis score index and testicular histology of caffeine treated rats

Ezim

2022

Andrologia

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The present study was designed to evaluate the protective effect of fluted pumpkin seeds (FPS) against caffeine (CAFF) induced testicular toxicity in rats. Thirty young healthy male Wistar rats (196 ± 12 g) were randomly organized into five sets of six animals per each group: control, caffeine (CAFF; 50 mg kg À1 bw) and FPS co-treatment groups (CAFF + 50 mg FPS, CAFF + 100 mg FPS and CAFF + 200 mg FPS kg À1 bw). CAFF and FPS were administered daily and twice per week respectively by oral gavage for 40 days. CAFF treatment decreased testicular lactate dehydrogenase enzyme activity level, which was attenuated on co-administration with FPS at 50 and 100 mg kg À1 bw. Furthermore, CAFF decreased seminiferous epithelia thickness and spermatogenesis score index and increased the number of tubules with abnormal histological features, which were attenuated on co-administration with FPS at 50 mg kg À1 bw much more than at the higher doses (p < 0.05). CAFF did not affect malondialdehyde and glutathione concentrations and glutathione peroxidase (GSH-Px) activity in the testes whereas FPS co-treatment at the higher doses elevated glutathione level and GSH-Px activity and did not affect spermatogenesis score index at the highest dose (200 mg kg À1 bw). Testicular malondialdehyde concentrations remained unaffected in all FPS co-treatment groups. Overall, FPS is able to minimize the CAFF-induced testicular injury at lower than at the higher tested doses.caffeine, fluted pumpkin seeds, histology, spermatogenesis, testis | INTRODUCTIONCaffeine (CAFF: 1,3,7-trimethylxanthine) is a naturally occurring purine-like alkaloid that is present in coffee, tea, cocoa bean and kola nuts. It is one of the most highly consumed psycho-stimulant in food supplements, beverages, energy drinks and some synthetic drugs (Akomolafe et al., 2019;Temple et al., 2017). It stimulates the central nervous system, which results in mental alertness and reduced drowsiness, loosening of smooth muscles and induction of heart rate. At higher doses, CAFF causes insomnia, tremors, increases nervousness and testicular injury in rats (

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Diet formulated with black seed flour activates regulatory androgenic enzymes and neuroendocrine hormones in leachate-exposed reproductive damage of rat testes

Cited by 2 publications

References 43 publications

Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats

Antioxidant and cytoprotective effects of Nigella sativa L. seeds on the testis of monosodium glutamate challenged rats

Fluted pumpkin seeds protect the spermatogenesis score index and testicular histology of caffeine treated rats

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