Diet, exposure to polycyclic aromatic hydrocarbons during pregnancy, and fetal growth: A comparative study of mothers and their fetuses in industrial and urban areas in Southwest Iran

Doroodzani, Atefeh Khalili; Dobaradaran, Sina; Akhbarizadeh, Razegheh; Raeisi, Alireza; Rahmani, Elham; Mahmoodi, Marzieh; Nabipour, Iraj; Keshmiri, Saeed; Darabi, Amir Hossein; Khamisipour, Gholamreza; Mahmudpour, Mehdi; Keshtkar, Mozhgan

doi:10.1016/j.envpol.2021.116668

Cited by 17 publications

(5 citation statements)

References 82 publications

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“…Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous organic pollutants that originate from petrogenic sources (non-combusted natural gas, crude oil and petroleum products) and pyrogenic sources (incomplete combustion of organic matter (Li et al, 2008a). The developing fetus is particularly vulnerable to environmental toxicants, and prenatal exposure to PAHs quantified in placental tissue or maternal urine has been linked to a variety of adverse perinatal and early childhood outcomes, including decreased birthweight ( Agarwal et al, 2020 ; Doroodzani et al, 2021 ) and increased risk of preterm birth ( Agarwal et al 2018 ; Freije et al 2022 ; Padula et al 2014 ). Prenatal exposure to airborne PAHs has also been positively associated with increased odds of cognitive developmental delays at age 3 in a population of inner city children ( Perera et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Paquette

Lapehn²,

Freije

et al. 2023

Environment International

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Section: Introductionmentioning

confidence: 99%

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Paquette

Lapehn²,

Freije

et al. 2023

Environment International

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“…Pregnant women are at an increased risk of adverse outcomes from PAHs exposure. Many follow-up studies have found that exposure to PAHs during the fetal period increases the risk of abnormal physical development including low birth weight and congenital defects [12][13][14][15]. It also has adverse effects on fetal neural development, cognitive development, and can cause behavior problems [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Association between atmospheric pollutant levels and oxidative stress in pregnant women and newborns in Urumqi

et al. 2023

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Background Frequent heavy air pollution occurred during the winter heating season of northern China. Particulate air pollution is a serious concern in Urumqi during heating season. Exposure to air pollution is known to increase adverse health outcomes, particularly oxidative damage. This study aimed to evaluate the impact of air pollution on oxidative damage around pregnant women and newborns in Urumqi. Methods This prospective observational study enrolled pregnant women in the Fifth Affiliated Hospital of Xinjiang Medical University between January 2019 and October 2019. Pregnant women and newborns were allocated into a heating season group (January - end of April 2019, October 2019) or non-heating season group (June 2019 - end of September) according to the specific delivery time. Venous blood, urine from the women and cord blood from their newborns were collected to measure the levels of PAHs and 8-deoxyguanosine (8-OHdG), a measure of oxidative stress. Results A total of 200 pregnant women and newborns were enrolled, with 100 pregnant women and newborns in the heating season group. Compared to the non-heating season group, the total contents of 8-OHdG in maternal urine, PAHs and 8-OHdG in maternal plasma and neonatal cord blood were higher in the heating season group (all P < 0.001). The average values for AQI, PM2.5, PM10, SO2, NO2, and CO were higher in the heating season group (all P < 0.001). Maternal and neonatal PAHs were correlated with 8-OHdG measurements in maternal urine (r = 0.288, P < 0.001 and r = 0.336, P < 0.001) and neonatal umbilical cord blood (r = 0.296, P < 0.001 and r = 0.252, P < 0.001). There was also a positive relationship between PAHs, 8-OHdG levels in pregnant women and their newborns and proximate air pollutant concentrations (all P < 0.05). Based on the results of multiple linear regression analysis, it was found that air pollutants(PM10, 03) had a great influence on the level of 8-OHdG in neonatal cord blood, and the contribution rate was high(R2 = 0.320). Based on the epidemiological questionnaire, a multiple linear regression model was established(R2 = 0.496). We found that 8-OHdG levels in neonatal umbilical cord blood were mainly affected by two aspects: (1) Biological samples collected during heating had higher levels of 8-OHdG in neonatal umbilical cord blood. (2) Study may suggest that in neonates, males are more sensitive to oxidative damage. Conclusion Particulate air pollution may increase PAHs exposure and oxidative DNA damage in pregnant women and newborns.

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“…PAHs and PAEs can enter the body through inhalation, ingestion and dermal contact and are excreted in urine and faeces. Studies have shown that PAH and PAE can cross the placenta from maternal serum into the foetal circulation [ 2 , 3 ], with potential implications for maternal and child health [ 4 , 5 , 6 , 7 , 8 , 9 ]. The placenta is highly sensitive to EEDs because it is rich in hormone receptors.…”

Section: Introductionmentioning

confidence: 99%

Determination of Polycyclic Aromatic Hydrocarbons (PAHs) and Phthalates in Human Placenta by Mixed Hexane/Ether Extraction and Gas Chromatography–Mass Spectrometry/Mass Spectrometry (GC-MS/MS)

Tao,

Tian,

Liao

et al. 2023

Metabolites

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In this study, we evaluated the extraction effect of three different extractants, namely hexane + ether (v/v = 3:1), acetonitrile and ethyl acetate, on polycyclic aromatic hydrocarbons (PAHs) and phthalic acid esters (PAEs) in placenta detected and analysed by triple quadrupole gas chromatography–mass spectrometry (GC-MS/MS). The results showed that n-hexane + ether (v/v = 3:1) had the highest extraction efficiency. Under the optimal conditions, the limits of detection (LOD) for the 10 PAHs were 0.003–0.0167 μg/L with relative standard deviations (RSD) of 1.4–5.48% and detection rates of 68.19–107.05%, and the correlation coefficients were (R2, 0.9982–0.9999). The LODs for the nine PAEs were 0.0015–3.5714 μg/L and the correlation coefficients were (R2, 0.9982–0.9999). The limits of detection (S/N = 3) for the nine PAHs were 0.0015–0.5714 μg/L with relative standard deviations (RSD) of 3.15–8.37%, and the detection rates were 80.45–112.59% with correlations of (R2, 0.9972–0.9998). The method was applied to the analysis of PAHs and phthalates in placenta samples from pregnant women. The method’s accuracy and applicability were demonstrated. In comparison with other methods for the detection of PAEs and PAHs, the method proposed in this paper has a wider linear range, lower minimum detection limit and comparable recovery with good correlation. This paper is dedicated to providing another method for improving the performance of extracting solid tissues.

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Diet, exposure to polycyclic aromatic hydrocarbons during pregnancy, and fetal growth: A comparative study of mothers and their fetuses in industrial and urban areas in Southwest Iran

Cited by 17 publications

References 82 publications

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Association between atmospheric pollutant levels and oxidative stress in pregnant women and newborns in Urumqi

Determination of Polycyclic Aromatic Hydrocarbons (PAHs) and Phthalates in Human Placenta by Mixed Hexane/Ether Extraction and Gas Chromatography–Mass Spectrometry/Mass Spectrometry (GC-MS/MS)

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