Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway

Lamy, Sylvie; Akla, Naoufal; Ouanouki, Amira; Lord‐Dufour, Simon; Béliveau, Richard

doi:10.1016/j.yexcr.2012.04.004

Cited by 61 publications

(45 citation statements)

References 52 publications

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“…Badache et al [19] suggested certain differences in the invasion and the proliferation pathways and that MAPK signaling is essential for IL6-induced invasion potential in breast cancer cells. Furthermore, the angiogenesis can be modulated by the IL6/STAT3 pathway [20]. IL6, originally identified as a B-cell differentiation factor, is a multifunctional cytokine that regulates the immune response, haemopoiesis, the acute phase response and inflammation.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-451 suppresses tumor cell growth by down-regulating IL6R gene expression

Liu

Wang

et al. 2014

Cancer Epidemiology

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Section: Discussionmentioning

confidence: 99%

MicroRNA-451 suppresses tumor cell growth by down-regulating IL6R gene expression

Liu

Wang

et al. 2014

Cancer Epidemiology

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“…Resveratrol has been shown to inhibit cell migration/invasion and metastasis in several types of cancer, including breast cancer [75]. In addition, it was reported that Interleukin 6 (IL-6) and its major efector, the signal transducer and activator of transcription 3 (STAT3), are part of an important inlammation-associated pathway in malignancies [76] and metastasis [77] in diferent types of cancer. Resveratrol might be a potential agent chemosensitization on several types of cancer.…”

Section: Efects On Angiogenesis and Metastasismentioning

confidence: 99%

Health Benefits of Phenolic Compounds Against Cancers

Basli¹,

Belkacem²,

Amrani³

2017

Phenolic Compounds - Biological Activity

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Phenolic compounds are the biggest group of phytochemicals, and many of them have been found in plant-based foods. Polyphenol-rich diets have been linked to many health beneits including cancer. The potential anti-carcinogenic mechanisms of action that have been so far identiied for phenolic compounds, as well as the feasibility reports occurred in vivo. In general terms, under the oxidative stress, polyphenols could act in those cellular mechanisms by participating in the modulation of the redox status and on multiple key elements in intracellular signal transduction pathways related to cell proliferation, diferentiation, apoptosis, inlammation, angiogenesis and metastasis. A protective role of polyphenols against carcinogenesis is supported by many studies carried out on animal models and diferent mechanisms of action have been proposed to explain such protective efects. Studies performed in animals have demonstrated that phenolic components can prevent and/or slow down the initiation-progression of diferent types of cancers. They act through the regulation of cell signal transduction and gene expression and exhibit either up or down regulation of genes controlling tumor development.

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“…Pokazano je da je apigenin doveo do supresije ekspresije HIF-1α i VEGF u PC-3 i DU145 malignim ćelijama, a ispoljio je i inhibitorni efekat na tumorsku angiogenezu in vivo [153]. Apigenin je ostvario inhibitorni efekat na migraciju, proliferaciju i formiranje tubularnih struktura HUVEC ćelija (humane endotelijalne ćelije umbilikalne vene) [154]. Antiangiogenetski efekat apigenina zasnivao se na modulaciji JAK/STAT i ERK signalnih puteva [154].…”

Section: Efekat Ekstrakata Na Angiogenezuunclassified

“…Apigenin je ostvario inhibitorni efekat na migraciju, proliferaciju i formiranje tubularnih struktura HUVEC ćelija (humane endotelijalne ćelije umbilikalne vene) [154]. Antiangiogenetski efekat apigenina zasnivao se na modulaciji JAK/STAT i ERK signalnih puteva [154].…”

Section: Efekat Ekstrakata Na Angiogenezuunclassified

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In vitro investigation of antitumor activities of extracts of endemic plant species Helichrysum zivojini ?ernjavski et So?ka U

Matić¹

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Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway

Cited by 61 publications

References 52 publications

MicroRNA-451 suppresses tumor cell growth by down-regulating IL6R gene expression

MicroRNA-451 suppresses tumor cell growth by down-regulating IL6R gene expression

Health Benefits of Phenolic Compounds Against Cancers

In vitro investigation of antitumor activities of extracts of endemic plant species Helichrysum zivojini ?ernjavski et So?ka U

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