Diet-Derived Advanced Glycation End Products (dAGEs) Induce Proinflammatory Cytokine Expression in Cardiac and Renal Tissues of Experimental Mice: Protective Effect of Curcumin

Rajan, Boopathi Sowndhar; Krishnan, Kalaiselvi; Vellaichamy, Elangovan

doi:10.1007/s12012-021-09697-4

Cited by 8 publications

(8 citation statements)

References 68 publications

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“…86 Curcumin (Turmeric Extract) is a phytochemical derived from turmeric, and it possesses antioxidant and anti-inflammatory properties that can attenuate AGE-induced oxidative stress and inflammation. 26 Curcumin has been reported to inhibit the activity of extracellular signal-regulated kinase (ERK), induce gene expression and peroxisome proliferation-activated receptor gamma (PPAR-gamma) activity, thereby inducing the expression of the AGE-R1 gene and partially eliminating the effects of AGE and preventing liver fibrosis by inhibiting the activation of hepatic stellate cells (hsc), the main effector of liver fibrosis. 25 In diabetic animals, curcumin can significantly reduce the oxidative stress and the accumulation of lipid peroxidation products in serum, and also prevent the accelerated accumulation of AGEs-collagen cross-link.…”

Section: Natural Anti-glycation Agentsmentioning

confidence: 99%

“…The anti-glycation role of the AGE receptors contributes to the protection of vital tissues and organs, such as the kidneys, eyes and blood vessels, against AGE-induced damage. 25,26 RAGE and AGER1 receptors facilitate the internalisation and clearance of AGEs from the extracellular environment. This reduces the overall AGE burden in tissues, limiting their harmful effects on cells and organs.…”

Section: Receptors For Advanced Glycation End-productsmentioning

confidence: 99%

“…Besides, AGER1 might inhibit the expression of RAGE and the activation of inflammation and oxidative stress. The anti‐glycation role of the AGE receptors contributes to the protection of vital tissues and organs, such as the kidneys, eyes and blood vessels, against AGE‐induced damage 25,26 …”

Section: Introductionmentioning

confidence: 99%

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The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

Wang,

Jiang,

Zhao

2024

Experimental Dermatology

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The advanced glycation end‐products (AGEs) are produced through non‐enzymatic glycation between reducing sugars and free amino groups, such as proteins, lipids or nucleic acids. AGEs can enter the body through daily dietary intake and can also be generated internally via normal metabolism and external stimuli. AGEs bind to cell surface receptors for AGEs, triggering oxidative stress and inflammation responses that lead to skin ageing and various diseases. Evidence shows that AGEs contribute to skin dysfunction and ageing. This review introduces the basic information, the sources, the metabolism and absorption of AGEs. We also summarise the detrimental mechanisms of AGEs to skin ageing and other chronic diseases. For the potential strategies for counteracting AGEs to skin and other organs, we summarised the pathways that could be utilised to resist glycation. Chemical and natural‐derived anti‐glycation approaches are overviewed. This work offers an understanding of AGEs to skin ageing and other chronic diseases and may provide perspectives for the development of anti‐glycation strategies.

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Section: Natural Anti-glycation Agentsmentioning

confidence: 99%

Section: Receptors For Advanced Glycation End-productsmentioning

confidence: 99%

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The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

Wang,

Jiang,

Zhao

2024

Experimental Dermatology

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“…The intake of dietary AGEs is considered a primary exogenous source of AGEs in the tissues and fluids of the human body [36,37]. Therefore, restraining the glycoxidation process, especially for foods containing a high protein content, would be an efficacious solution to prevent glycation-induced negative consequences [38,39]. In this work, the Monascus fermentation products with a high content of Monascus pigments (MPs) were acquired referring to the method provided in the Supplementary material, and their potential against the glycosylation of BSA by Fru was evaluated by detecting the contents of the representative products.…”

Section: Anti-glycation Activity Of Monascus Pigments (Mps)mentioning

confidence: 99%

Revealing the Hypoglycemic Effect of Red Yeast Rice: Perspectives from the Inhibition of α-Glucosidase and the Anti-Glycation Capability by Ankaflavin and Monascin

Wu,

Dong,

Zhang

et al. 2024

Foods

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Red yeast rice dietary supplements have been proven to ameliorate hyperglycemia, but the mechanism was unclear. In this work, ankaflavin (AK) and monascin (MS), as typical pigments derived from red yeast rice, were found to exert noteworthy inhibitory ability against α-glucosidase, with an IC50 of 126.5 ± 2.5 and 302.6 ± 2.5 μM, respectively, compared with acarbose (IC50 = 341.3 ± 13.6 μM). They also exhibited mixed-type inhibition of α-glucosidase in vitro and caused fluorescence quenching through the static-quenching process. Molecular-docking studies indicated that AK and MS bind to amino acid residues outside the catalytic center, which induces structural changes in the enzyme, thus influencing its catalytic activity. The anti-glycation ability of Monascus-fermented products was evaluated, and they exhibited a high inhibition rate of 87.1% in fluorescent advanced glycation end-product formation at a concentration of 0.2 mg mL−1, while aminoguanidine showed a rate of 75.7% at the same concentration. These results will be significant in broadening the application scope of Monascus pigments, especially AK and MS, in treating type 2 diabetes.

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“…Certain identical foods act as an external source of AGEs, including dry-heated foods, baked goods, edible oils, etc. 11 , 12 . Based on molecular mechanisms, AGES interacts with the transmembrane receptors for AGEs (RAGE) 13 , which further activates the inflammatory signaling pathway and releases pro-inflammatory cytokines (IL-1 β, IL-6), followed by the production of matrix metalloproteinase (MMP) and the degradation of collagen and other components of the dermal extracellular matrix (ECM), thereby ultimately facilitating the aging process 14 .…”

Section: Introductionmentioning

confidence: 99%

Glyoxal-derived advanced glycation end products (GO-AGEs) with UVB critically induce skin inflammaging: in vitro and in silico approaches

Sultana,

Parveen,

Kang

et al. 2024

Sci Rep

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Advanced glycation end products (AGEs) have potential implications on several diseases including skin inflammation and aging. AGEs formation can be triggered by several factors such as UVB, glyoxal and methylglyoxal etc. However, little attention has been paid to glyoxal-derived AGEs (GO-AGEs) and UVB-induced skin inflammaging, with none have investigated together. This study aimed to investigate the possible role of GO-AGEs and UVB in skin inflammaging focusing on revealing its molecular mechanisms. The effects of GO-AGEs in the presence or absence of UVB were studied by using enzyme linked immunosorbent assay, western blotting, qPCR, flow cytometry and in silico approaches. In HaCaT cells, GO-AGEs in the presence of UVB irradiation (125 mJ/cm2) dramatically enhanced the release of different pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) with further activation of RAGE signaling pathways (NF-κB, COX 2, and IL- 1β) and increased oxidative stress also noticed in NHEK cells. In NHDF cells, extracellular matrix disruption noted via increasing matrix metalloproteinase release and decreasing collagen type 1 and SIRT1 expression. Besides that, the docking scores obtained from the molecular docking study support the above-mentioned results. This study strongly suggests the pivotal role of GO-AGEs in skin inflammaging and illuminates novel molecular pathways for searching most effective and updated anti-aging therapy.

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Diet-Derived Advanced Glycation End Products (dAGEs) Induce Proinflammatory Cytokine Expression in Cardiac and Renal Tissues of Experimental Mice: Protective Effect of Curcumin

Cited by 8 publications

References 68 publications

The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

The effects of advanced glycation end‐products on skin and potential anti‐glycation strategies

Revealing the Hypoglycemic Effect of Red Yeast Rice: Perspectives from the Inhibition of α-Glucosidase and the Anti-Glycation Capability by Ankaflavin and Monascin

Glyoxal-derived advanced glycation end products (GO-AGEs) with UVB critically induce skin inflammaging: in vitro and in silico approaches

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