Diet-dependent acid load and the risk of breast cancer: A case–control study

Heidari, Zeinab; Pashayee-Khamene, Fereshteh; Jalali, Saba; Karandish, Majid; Mohammadi, S.; Rashidkhani, Bahram

doi:10.1016/j.clnesp.2023.03.004

Cited by 1 publication

(1 citation statement)

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“…Diet can contain acidic or alkaline load. Indeed, the idea that diet-induced acidosis can cause chronic disease has been a topic of interest for years 11 – 14 . Some observational studies have investigated the possible link between diets that produce acid with an increased risk of hypertension (HTN) 15 , 16 , osteoporosis 17 , 18 , insulin resistance (IR), and diabetes 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Dietary acid load and cirrhosis-related mortality: a prospective cohort study

Pashayee-Khamene,

Heidari,

Fotros

et al. 2024

Sci Rep

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As a global health concern, cirrhosis contributes significantly to morbidity and mortality. This prospective cohort study aimed to investigate the association between dietary acid load (DAL) and cirrhosis-related mortality. Present study was conducted on 121 patients with newly diagnosed cirrhosis who were followed up for 48 months. Anthropometric measures, nutritional status and dietary intakes were assessed and DAL was estimated based on potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. Crude and multivariable-adjusted hazard ratios (HR) with 95% confidence intervals (CI) were estimated using Cox proportional hazard analyses. Participants in the high PRAL and NEAP scores had significantly higher intakes of grains and lower intakes of fruits and vegetables. Also, the intake of dairy products and legumes, nuts and seeds decreased significantly with increasing NEAP score. After adjustment of all the confounders, the risk of mortality in the second and third tertiles of PRAL was 5.9 times and 10.97 higher than those in the first tertile, respectively (P trend: 0.006). Similarly, comparing the risk of mortality in the second and third tertiles with the first tertile of NEAP showed a 4.46-fold and 12.3-fold increased risk, respectively (P trend: 0.010). Our findings suggested that DAL was significantly associated with cirrhosis-related mortality and highlight the need for further research to understand the underlying mechanisms and establish optimal DAL levels in cirrhotic patients.

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