Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components

Abstract

Chemopreventive agents that the general population can consume for prolonged periods of time with minimal risk of any side effects are of great interest to all in search of a solution to the pervasive incidence of cancer. Dietary bioactive components have been found to modulate many deregulated molecular pathways associated with the initiation and progression of different types of cancer. Combination regimens with dietary bioactive components are a promising strategy for cancer chemoprevention because they may offer enhanced protective effects against cancer development but cause little or no adverse effects. This article provides an overview of studies examining the combination of dietary bioactive components for the chemoprevention of major types of cancer. A better understanding of existing research on the combination of dietary bioactive components will provide an important basis for the rational design of future combination studies and the successful development of cancer chemoprevention strategies.

Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF-κB and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3β

“…There are many bioactive food components with anti-inflammatory activity that are being investigated in relation to the management and treatment of inflammatory bowel conditions that may provide a feasible and safe way to reduce CRC risk (8, 9). The sulfur-containing constituents derived from garlic; including diallyl disulfide (DADS) are such examples that have been previously reported to exert anti-inflammatory effects (10).…”

Wedelolactone protects human bronchial epithelial cell injury against cigarette smoke extract-induced oxidant stress and inflammation responses through Nrf2 pathway

“…CS stimulates normal human bronchial epithelial (NHBE) cell which cause a multistep process involving morphologic and molecular modifications. Then, complex of alterations occurs gradually and lead to malignant transformation with unregulated clonal expansion and cellular proliferation [6]. And then, intercellular communication has evolved to control proliferation with the release of oxidants and an increase in inflammatory responses.…”

CIMMYT Series on Carbohydrates, Wheat, Grains, and Health: Carbohydrates, Grains, and Whole Grains and Disease Prevention. Part IV. Cancer Risk: Lung, Prostate, and Stomach

“…Dietary bioactives seem to reduce lung cancer risk (12,13), and many fruits and vegetables and grain-based, CHO-rich foods contain beneficial bioactive components. However, even for fruits, vegetables, and foods containing beneficial compounds, the research results are inconsistent.…”